Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18) - PubMed (original) (raw)

Comparative Study

. 1995 Feb 24;80(4):631-8.

doi: 10.1016/0092-8674(95)90517-0.

Affiliations

• PMID: 7867070
• DOI: 10.1016/0092-8674(95)90517-0

Free article

Comparative Study

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

J O Lee et al. Cell. 1995.

Free article

Abstract

We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.

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