BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes - PubMed (original) (raw)

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

P Boël et al. Immunity. 1995 Feb.

Free article

Abstract

Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named BAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw 1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy.

PubMed Disclaimer

Similar articles

• A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.
  Van den Eynde B, Peeters O, De Backer O, Gaugler B, Lucas S, Boon T. Van den Eynde B, et al. J Exp Med. 1995 Sep 1;182(3):689-98. doi: 10.1084/jem.182.3.689. J Exp Med. 1995. PMID: 7544395 Free PMC article.
• Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.
  Gaugler B, Van den Eynde B, van der Bruggen P, Romero P, Gaforio JJ, De Plaen E, Lethé B, Brasseur F, Boon T. Gaugler B, et al. J Exp Med. 1994 Mar 1;179(3):921-30. doi: 10.1084/jem.179.3.921. J Exp Med. 1994. PMID: 8113684 Free PMC article.
• Autologous cytolytic T lymphocytes recognize a MAGE-1 nonapeptide on melanomas expressing HLA-Cw*1601.
  van der Bruggen P, Szikora JP, Boël P, Wildmann C, Somville M, Sensi M, Boon T. van der Bruggen P, et al. Eur J Immunol. 1994 Sep;24(9):2134-40. doi: 10.1002/eji.1830240930. Eur J Immunol. 1994. PMID: 7522162
• Genes coding for tumor antigens recognized by human cytolytic T lymphocytes.
  Coulie PG, Weynants P, Lehmann F, Herman J, Brichard V, Wölfel T, Van Pel A, De Plaen E, Brasseur F, Boon T. Coulie PG, et al. J Immunother Emphasis Tumor Immunol. 1993 Aug;14(2):104-9. doi: 10.1097/00002371-199308000-00004. J Immunother Emphasis Tumor Immunol. 1993. PMID: 8280701 Review.
• The immunogenic properties of melanoma-associated antigens recognized by cytotoxic T lymphocytes.
  Kirkin AF, Dzhandzhugazyan K, Zeuthen J. Kirkin AF, et al. Exp Clin Immunogenet. 1998;15(1):19-32. doi: 10.1159/000019050. Exp Clin Immunogenet. 1998. PMID: 9619397 Review.

Cited by

• Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy.
  Shao W, Yao Y, Yang L, Li X, Ge T, Zheng Y, Zhu Q, Ge S, Gu X, Jia R, Song X, Zhuang A. Shao W, et al. Exp Hematol Oncol. 2024 Apr 3;13(1):37. doi: 10.1186/s40164-024-00504-8. Exp Hematol Oncol. 2024. PMID: 38570883 Free PMC article. Review.
• Serum NY-ESO-1 and p53 antibodies as useful tumor markers in gastric cancer.
  Kawada J, Saito T, Kurokawa Y, Kawabata R, Takeno A, Takeoka T, Nose Y, Wada H, Eguchi H, Doki Y; Osaka University Clinical Research Group for Gastroenterological Study. Kawada J, et al. Ann Gastroenterol Surg. 2023 Nov 20;8(2):243-250. doi: 10.1002/ags3.12757. eCollection 2024 Mar. Ann Gastroenterol Surg. 2023. PMID: 38455491 Free PMC article.
• Adoptive neoantigen-reactive T cell therapy: improvement strategies and current clinical researches.
  Huang R, Zhao B, Hu S, Zhang Q, Su X, Zhang W. Huang R, et al. Biomark Res. 2023 Apr 17;11(1):41. doi: 10.1186/s40364-023-00478-5. Biomark Res. 2023. PMID: 37062844 Free PMC article. Review.
• Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer.
  Nin DS, Deng LW. Nin DS, et al. Cells. 2023 Mar 17;12(6):926. doi: 10.3390/cells12060926. Cells. 2023. PMID: 36980267 Free PMC article. Review.
• Tumor microenvironment antigens.
  Andersen MH. Andersen MH. Semin Immunopathol. 2023 Mar;45(2):253-264. doi: 10.1007/s00281-022-00966-0. Epub 2022 Sep 29. Semin Immunopathol. 2023. PMID: 36175673 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

• Research Materials

  • NCI CPTC Antibody Characterization Program