Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non-NMDA receptor mediated neurotoxicity - PubMed (original) (raw)
Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non-NMDA receptor mediated neurotoxicity
M T Fernández-Sánchez et al. FEBS Lett. 1993.
Free article
Abstract
We have investigated the ability of bFGF to protect cerebellar neurons from neurotoxicity by excitatory amino acids. We have found that preincubation with 1-2.5 nM bFGF for 1-6 days significantly protected neurons from excitotoxic damage via NMDA receptors as well as ionotropic non-NMDA receptors. bFGF neuroprotection appeared not to be dependent upon neuronal differentiation and was not mimicked by other neurotrophins including BDNF, NT-3 and NGF. A greater rise in extracellular calcium-dependent cGMP formation, following either depolarization or excitatory amino acid receptor activation was observed in bFGF-pretreated neurons. We suggest that neuroprotection from excitotoxicity following bFGF treatment may be associated to the modulation of neurochemical pathways dependent upon extracellular calcium influx.
Similar articles
- Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons.
Mattson MP, Kumar KN, Wang H, Cheng B, Michaelis EK. Mattson MP, et al. J Neurosci. 1993 Nov;13(11):4575-88. doi: 10.1523/JNEUROSCI.13-11-04575.1993. J Neurosci. 1993. PMID: 7901348 Free PMC article. - Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity.
Freese A, Finklestein SP, DiFiglia M. Freese A, et al. Brain Res. 1992 Mar 20;575(2):351-5. doi: 10.1016/0006-8993(92)90104-h. Brain Res. 1992. PMID: 1349256 - Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death.
Díaz-Trelles R, Novelli A, Vega JA, Marini A, Fernández-Sánchez MT. Díaz-Trelles R, et al. Brain Res. 2000 Oct 13;880(1-2):17-27. doi: 10.1016/s0006-8993(00)02627-5. Brain Res. 2000. PMID: 11032986 - Toward the development of strategies to prevent ischemic neuronal injury. In vitro studies.
Marini AM, Spiga G, Mocchetti I. Marini AM, et al. Ann N Y Acad Sci. 1997 Oct 15;825:209-19. doi: 10.1111/j.1749-6632.1997.tb48431.x. Ann N Y Acad Sci. 1997. PMID: 9369988 Review. - N-methyl-D-aspartate and TrkB receptor activation in cerebellar granule cells: an in vitro model of preconditioning to stimulate intrinsic survival pathways in neurons.
Jiang X, Zhu D, Okagaki P, Lipsky R, Wu X, Banaudha K, Mearow K, Strauss KI, Marini AM. Jiang X, et al. Ann N Y Acad Sci. 2003 May;993:134-45; discussion 159-60. doi: 10.1111/j.1749-6632.2003.tb07522.x. Ann N Y Acad Sci. 2003. PMID: 12853306 Free PMC article. Review.
Cited by
- Granule neuron regulation of Purkinje cell development: striking a balance between neurotrophin and glutamate signaling.
Morrison ME, Mason CA. Morrison ME, et al. J Neurosci. 1998 May 15;18(10):3563-73. doi: 10.1523/JNEUROSCI.18-10-03563.1998. J Neurosci. 1998. PMID: 9570788 Free PMC article. - Antihistamine terfenadine inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of L-type voltage sensitive calcium channels.
Díaz-Trelles R, Fernández-Sánchez MT, Marini AM, Novelli A. Díaz-Trelles R, et al. Neurotox Res. 2002 Feb;4(1):15-24. doi: 10.1080/10298420290007583. Neurotox Res. 2002. PMID: 12826489 - Interleukin-10 prevents glutamate-mediated cerebellar granule cell death by blocking caspase-3-like activity.
Bachis A, Colangelo AM, Vicini S, Doe PP, De Bernardi MA, Brooker G, Mocchetti I. Bachis A, et al. J Neurosci. 2001 May 1;21(9):3104-12. doi: 10.1523/JNEUROSCI.21-09-03104.2001. J Neurosci. 2001. PMID: 11312295 Free PMC article. - Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function.
Sanchez-Perez A, Llansola M, Cauli O, Felipo V. Sanchez-Perez A, et al. Cerebellum. 2005;4(3):162-70. doi: 10.1080/14734220510008003. Cerebellum. 2005. PMID: 16147948 Review. - Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.
Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG. Choudary PV, et al. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15653-8. doi: 10.1073/pnas.0507901102. Epub 2005 Oct 17. Proc Natl Acad Sci U S A. 2005. PMID: 16230605 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials