Effect of parathyroid hormone-related peptide supplementation of soy protein formulas in the neonatal pig model - PubMed (original) (raw)
Effect of parathyroid hormone-related peptide supplementation of soy protein formulas in the neonatal pig model
L S Hillman et al. J Bone Miner Res. 1994 Jul.
Abstract
PTH-related peptide (PTHrP) is found in all milks, including human and pig. To define a role for PTHrP in milk, 2-day-old piglets were randomized to receive soy formula devoid of PTHrP or supplemented with 1 nM synthetic PTHrP(1-86) (n = 8 per group). The number of serum samples with detectable PTHrP by immunoassay (Incstar) and radiometric assay (Nichols) was 9 of 33 and 3 of 13 in PTHrP- and 8 of 27 and 3 of 15 in PTHrP+ formula-fed piglets and 8 of 14 and 7 of 12 in naturally suckling piglets, respectively. Serum and urine concentrations of calcium and magnesium and total and bone alkaline phosphatase were similar in both groups at 3, 6, 10, and 17 days of age. No differences were seen in bone mineral content of the tibia measured by single-photon absorptiometry (BMC 0.22 +/- 0.06 and 0.22 +/- 0.10) or dual x-ray absorption (BMC 1.43 +/- 0.36 and 1.31 +/- 0.78) either in vivo or on excised bone or by measurement of Ca, Mg, or P content or total bone ash (1.26 +/- 0.26 and 1.38 +/- 0.28 mg). Intestinal histology, serum intestinal alkaline phosphatase, and net absorption and retention of Ca, Mg, and P in balances from age 11-17 days were all similar. As in humans, however, a developmental pattern was seen for phosphorus regulation in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Fractional calcium absorption is increased in girls with Rett syndrome.
Motil KJ, Schultz RJ, Abrams S, Ellis KJ, Glaze DG. Motil KJ, et al. J Pediatr Gastroenterol Nutr. 2006 Apr;42(4):419-26. doi: 10.1097/01.mpg.0000189370.22288.0c. J Pediatr Gastroenterol Nutr. 2006. PMID: 16641581 - Beneficial effect of copper supplementation on deposition of fluoride in bone in fluoride- and molybdenum-fed rabbits.
Khandare AL, Suresh P, Kumar PU, Lakshmaiah N, Manjula N, Rao GS. Khandare AL, et al. Calcif Tissue Int. 2005 Oct;77(4):233-8. doi: 10.1007/s00223-005-0071-2. Epub 2005 Sep 28. Calcif Tissue Int. 2005. PMID: 16193231 - Effects of infusion of human parathyroid hormone-related protein-(1-40) in nude mice: histomorphometric and biochemical investigations.
Rosol TJ, Capen CC, Horst RL. Rosol TJ, et al. J Bone Miner Res. 1988 Dec;3(6):699-706. doi: 10.1002/jbmr.5650030616. J Bone Miner Res. 1988. PMID: 2855193 - [Parathyroid hormone-related protein (PTHrP)].
Watanabe K, Tomita A. Watanabe K, et al. Nihon Rinsho. 1995 Mar;53 Su Pt 2:397-400. Nihon Rinsho. 1995. PMID: 8753264 Review. Japanese. No abstract available. - Mineral and bone physiology in the foetus, preterm and full-term neonates.
Sethi A, Priyadarshi M, Agarwal R. Sethi A, et al. Semin Fetal Neonatal Med. 2020 Feb;25(1):101076. doi: 10.1016/j.siny.2019.101076. Epub 2019 Dec 16. Semin Fetal Neonatal Med. 2020. PMID: 31882392 Review.
Cited by
- Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.
VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ. VanHouten JN, et al. J Clin Invest. 2003 Nov;112(9):1429-36. doi: 10.1172/JCI19504. J Clin Invest. 2003. PMID: 14597768 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous