Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb - PubMed (original) (raw)

. 1994 Dec 1;54(23):6078-82.

Affiliations

• PMID: 7954450

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb

Y Li et al. Cancer Res. 1994.

Abstract

Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the retinoblastoma protein, pRb. The formation of complexes and enzymatic activity of cyclin D-CDK4 and cyclin D-CDK6 kinases is negatively regulated by p16INK4 (MTS1/CDK4I/CDKN2) via its specific interaction with CDK4 and CDK6 catalytic subunits. Here we report that the p16 mRNA accumulates to a high level in cells lacking pRb function and transcription of p16 is repressed by pRb. Our results provide evidence supporting a feedback regulatory loop involving pRb, p16, and cyclin-dependent kinases.

PubMed Disclaimer

Similar articles

• The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
  Bartkova J, Lukas J, Guldberg P, Alsner J, Kirkin AF, Zeuthen J, Bartek J. Bartkova J, et al. Cancer Res. 1996 Dec 1;56(23):5475-83. Cancer Res. 1996. PMID: 8968104
• Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.
  Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J. Lukas J, et al. Nature. 1995 Jun 8;375(6531):503-6. doi: 10.1038/375503a0. Nature. 1995. PMID: 7777060
• [Cyclin D, CDK4 and p16 expression in colorectal cancer].
  Ikeda K, Monden T, Tsujie M, Izawa H, Yamamoto H, Ohnishi T, Ohue M, Sekimoto M, Tomita N, Monden M. Ikeda K, et al. Nihon Rinsho. 1996 Apr;54(4):1054-9. Nihon Rinsho. 1996. PMID: 8920673 Review. Japanese.
• Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks.
  Adams PD. Adams PD. Biochim Biophys Acta. 2001 Mar 21;1471(3):M123-33. doi: 10.1016/s0304-419x(01)00019-1. Biochim Biophys Acta. 2001. PMID: 11250068 Review.

Cited by

• P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination.
  Weng W, Zhang B, Deng D. Weng W, et al. iScience. 2024 Sep 3;27(10):110882. doi: 10.1016/j.isci.2024.110882. eCollection 2024 Oct 18. iScience. 2024. PMID: 39351198 Free PMC article.
• Upregulation of YPEL3 expression and induction of human breast cancer cell death by microRNAs.
  Lee B, Kwon YJ, Shin S, Kwon TU, Park H, Lee H, Kwak JH, Chun YJ. Lee B, et al. Toxicol Res. 2024 Jun 21;40(4):599-611. doi: 10.1007/s43188-024-00251-2. eCollection 2024 Oct. Toxicol Res. 2024. PMID: 39345743 Free PMC article.
• CIP/KIP and INK4 families as hostages of oncogenic signaling.
  Csergeová L, Krbušek D, Janoštiak R. Csergeová L, et al. Cell Div. 2024 Apr 1;19(1):11. doi: 10.1186/s13008-024-00115-z. Cell Div. 2024. PMID: 38561743 Free PMC article. Review.
• p16 Expression in Laryngeal Squamous Cell Carcinoma: A Surrogate or Independent Prognostic Marker?
  Gallus R, Rizzo D, Rossi G, Mureddu L, Galli J, Artuso A, Bussu F. Gallus R, et al. Pathogens. 2024 Jan 24;13(2):100. doi: 10.3390/pathogens13020100. Pathogens. 2024. PMID: 38392838 Free PMC article. Review.
• Human Papillomavirus Infection in Penile Cancer: Multidimensional Mechanisms and Vaccine Strategies.
  Wei L, Huang K, Han H, Liu RY. Wei L, et al. Int J Mol Sci. 2023 Nov 27;24(23):16808. doi: 10.3390/ijms242316808. Int J Mol Sci. 2023. PMID: 38069131 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal