Neurotrophin-6 is a new member of the nerve growth factor family - PubMed (original) (raw)
. 1994 Nov 17;372(6503):266-9.
doi: 10.1038/372266a0.
Affiliations
- PMID: 7969471
- DOI: 10.1038/372266a0
Neurotrophin-6 is a new member of the nerve growth factor family
R Götz et al. Nature. 1994.
Abstract
During vertebrate development, many neurons depend for survival and differentiation on their target cells. The best documented mediator of such a retrograde trophic action is the neurotrophin nerve growth factor (NGF). NGF and the other known members of the neurotrophin family, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are conserved as distinct genes over large evolutionary distances. Here we report the cloning of neurotrophin-6 (NT-6), a new member of this family from the teleost fish Xiphophorus. NT-6 distinguishes itself from the other known neurotrophins in that it is not found as a soluble protein in the medium of producing cells. The addition of heparin (but not chondroitin) effects the release of NT-6 from cell surface and extracellular matrix molecules. Recombinant purified NT-6 has a spectrum of actions similar to NGF on chick sympathetic and sensory neurons, albeit with a lower potency. NT-6 is expressed in the embryonic valvulla cerebelli; expression persists in some adult tissues. The interaction of NT-6 with heparin-binding molecules may modulate its action in the nervous system.
Similar articles
- Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons.
Koliatsos VE, Price DL, Gouras GK, Cayouette MH, Burton LE, Winslow JW. Koliatsos VE, et al. J Comp Neurol. 1994 May 8;343(2):247-62. doi: 10.1002/cne.903430206. J Comp Neurol. 1994. PMID: 8027442 - Characterization of neurotrophin receptors by affinity crosslinking.
Escandón E, Burton LE, Szönyi E, Nikolics K. Escandón E, et al. J Neurosci Res. 1993 Apr 15;34(6):601-13. doi: 10.1002/jnr.490340602. J Neurosci Res. 1993. PMID: 8315660 - Mitogenic and anti-proliferative signals for neural crest cells and the neurogenic action of TGF-beta1.
Zhang JM, Hoffmann R, Sieber-Blum M. Zhang JM, et al. Dev Dyn. 1997 Mar;208(3):375-86. doi: 10.1002/(SICI)1097-0177(199703)208:3<375::AID-AJA8>3.0.CO;2-F. Dev Dyn. 1997. PMID: 9056641 - Neurotrophins and other growth factors in the generation of retinal neurons.
Frade JM, Bovolenta P, Rodríguez-Tébar A. Frade JM, et al. Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):243-51. doi: 10.1002/(SICI)1097-0029(19990515/01)45:4/5<243::AID-JEMT8>3.0.CO;2-S. Microsc Res Tech. 1999. PMID: 10383117 Review. - Classical and novel directions in neurotrophin transport and research: anterograde transport of brain-derived neurotrophic factor by sensory neurons.
Tonra JR. Tonra JR. Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):225-32. doi: 10.1002/(SICI)1097-0029(19990515/01)45:4/5<225::AID-JEMT6>3.0.CO;2-1. Microsc Res Tech. 1999. PMID: 10383115 Review.
Cited by
- Immunolocalization of Two Neurotrophins, NGF and BDNF, in the Pancreas of the South American Sea Lion Otaria flavescens and Bottlenose Dolphin Tursiops truncatus.
Gatta C, Avallone L, Costagliola A, Scocco P, D'Angelo L, de Girolamo P, De Felice E. Gatta C, et al. Animals (Basel). 2024 Aug 13;14(16):2336. doi: 10.3390/ani14162336. Animals (Basel). 2024. PMID: 39199870 Free PMC article. - The Neurotrophin System in the Postnatal Brain-An Introduction.
von Bohlen Und Halbach O, Klausch M. von Bohlen Und Halbach O, et al. Biology (Basel). 2024 Jul 24;13(8):558. doi: 10.3390/biology13080558. Biology (Basel). 2024. PMID: 39194496 Free PMC article. Review. - Emerging Insights into the Role of BDNF on Health and Disease in Periphery.
Ichimura-Shimizu M, Kurrey K, Miyata M, Dezawa T, Tsuneyama K, Kojima M. Ichimura-Shimizu M, et al. Biomolecules. 2024 Apr 5;14(4):444. doi: 10.3390/biom14040444. Biomolecules. 2024. PMID: 38672461 Free PMC article. Review. - Role of Neurotrophins in Orofacial Pain Modulation: A Review of the Latest Discoveries.
Bonomini F, Favero G, Castrezzati S, Borsani E. Bonomini F, et al. Int J Mol Sci. 2023 Aug 4;24(15):12438. doi: 10.3390/ijms241512438. Int J Mol Sci. 2023. PMID: 37569811 Free PMC article. Review. - Brain Proteome and Behavioural Analysis in Wild Type, BDNF+/- and BDNF-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures.
Maffioli E, Angiulli E, Nonnis S, Grassi Scalvini F, Negri A, Tedeschi G, Arisi I, Frabetti F, D'Aniello S, Alleva E, Cioni C, Toni M. Maffioli E, et al. Int J Mol Sci. 2022 May 17;23(10):5606. doi: 10.3390/ijms23105606. Int J Mol Sci. 2022. PMID: 35628418 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials