Demonstration of neurofibrillary tangles and neuropil thread-like structures in spinal cord white matter in parkinsonism-dementia complex on Guam and in Guamanian amyotrophic lateral sclerosis - PubMed (original) (raw)

Demonstration of neurofibrillary tangles and neuropil thread-like structures in spinal cord white matter in parkinsonism-dementia complex on Guam and in Guamanian amyotrophic lateral sclerosis

T Umahara et al. Acta Neuropathol. 1994.

Abstract

This report concerns the demonstration and distribution of neurofibrillary tangles (NFTs), immunoreactive neuropil thread-like structures and dots in the spinal cord gray and white matter of six patients with parkinsonism-dementia complex on Guam and five patients with Guamanian amyotrophic lateral sclerosis (ALS). A monoclonal antibody to Alzheimer NFTs was used. NFTs were found in the spinal cord gray matter and white matter and all patients had immunoreactive neuropil thread-like structures and dots in the gray matter as well as in the white matter. They were particularly numerous in the lateral funiculus of patients with Guamanian ALS.

PubMed Disclaimer

Cited by

A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.
Chernoff N, Hill DJ, Diggs DL, Faison BD, Francis BM, Lang JR, Larue MM, Le TT, Loftin KA, Lugo JN, Schmid JE, Winnik WM. Chernoff N, et al. J Toxicol Environ Health B Crit Rev. 2017;20(4):1-47. doi: 10.1080/10937404.2017.1297592. Epub 2017 Jun 9. J Toxicol Environ Health B Crit Rev. 2017. PMID: 28598725 Free PMC article. Review.
Tau and axonopathy in neurodegenerative disorders.
Higuchi M, Lee VM, Trojanowski JQ. Higuchi M, et al. Neuromolecular Med. 2002;2(2):131-50. doi: 10.1385/NMM:2:2:131. Neuromolecular Med. 2002. PMID: 12428808 Review.
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE. McKee AC, et al. J Neuropathol Exp Neurol. 2010 Sep;69(9):918-29. doi: 10.1097/NEN.0b013e3181ee7d85. J Neuropathol Exp Neurol. 2010. PMID: 20720505 Free PMC article.

References

1. Am J Pathol. 1985 Aug;120(2):282-91 - PubMed
1. Arch Neurol. 1962 Sep;7:227-42 - PubMed
1. J Neuropathol Exp Neurol. 1992 Nov;51(6):594-600 - PubMed
1. Arch Neurol. 1966 Jul;15(1):35-51 - PubMed
1. J Geriatr Psychiatry Neurol. 1991 Jul-Sep;4(3):134-42 - PubMed

Demonstration of neurofibrillary tangles and neuropil thread-like structures in spinal cord white matter in parkinsonism-dementia complex on Guam and in Guamanian amyotrophic lateral sclerosis - PubMed (original) (raw)