Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1 - PubMed (original) (raw)

Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1

J E Sligh Jr et al. Proc Natl Acad Sci U S A. 1993.

Abstract

Gene targeting was used to produce mice deficient in intercellular adhesion molecule 1 (ICAM-1) or CD54, an immunoglobulin-like cell adhesion molecule that binds beta 2 integrins. Homozygous deficient animals develop normally, are fertile, and have a moderate granulocytosis. The nature of the mutation, RNA analysis, and immunostaining are consistent with complete loss of surface expression of ICAM-1. Deficient mice exhibit prominent abnormalities of inflammatory responses including impaired neutrophil emigration in response to chemical peritonitis and decreased contact hypersensitivity to 2,4-dinitrofluorobenzene. Mutant cells provided negligible stimulation in the mixed lymphocyte reaction, although they proliferated normally as responder cells. These mutant animals will be extremely valuable for examining the role of ICAM-1 and its counterreceptors in inflammatory disease processes and atherosclerosis.

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References

1. 1. Cell. 1991 Jun 14;65(6):961-71 - PubMed
2. 1. J Immunol. 1990 Jun 15;144(12):4579-86 - PubMed
3. 1. J Immunol. 1985 Mar;134(3):1403-7 - PubMed
4. 1. J Immunol. 1991 Aug 15;147(4):1127-33 - PubMed
5. 1. Blood. 1991 Oct 15;78(8):2089-97 - PubMed

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