Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3 - PubMed (original) (raw)

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

X W Wang et al. Proc Natl Acad Sci U S A. 1994.

Abstract

Chronic active hepatitis caused by infection with hepatitis B virus, a DNA virus, is a major risk factor for human hepatocellular carcinoma. Since the oncogenicity of several DNA viruses is dependent on the interaction of their viral oncoproteins with cellular tumor-suppressor gene products, we investigated the interaction between hepatitis B virus X protein (HBX) and human wild-type p53 protein. HBX complexes with the wild-type p53 protein and inhibits its sequence-specific DNA binding in vitro. HBX expression also inhibits p53-mediated transcriptional activation in vivo and the in vitro association of p53 and ERCC3, a general transcription factor involved in nucleotide excision repair. Therefore, HBX may affect a wide range of p53 functions and contribute to the molecular pathogenesis of human hepatocellular carcinoma.

PubMed Disclaimer

Similar articles

• Hepatitis B virus X protein inhibits nucleotide excision repair.
  Jia L, Wang XW, Harris CC. Jia L, et al. Int J Cancer. 1999 Mar 15;80(6):875-9. doi: 10.1002/(sici)1097-0215(19990315)80:6<875::aid-ijc13>3.0.co;2-z. Int J Cancer. 1999. PMID: 10074921
• Abrogation of p53-induced apoptosis by the hepatitis B virus X gene.
  Wang XW, Gibson MK, Vermeulen W, Yeh H, Forrester K, Stürzbecher HW, Hoeijmakers JH, Harris CC. Wang XW, et al. Cancer Res. 1995 Dec 15;55(24):6012-6. Cancer Res. 1995. PMID: 8521383
• Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation.
  Truant R, Antunovic J, Greenblatt J, Prives C, Cromlish JA. Truant R, et al. J Virol. 1995 Mar;69(3):1851-9. doi: 10.1128/JVI.69.3.1851-1859.1995. J Virol. 1995. PMID: 7853526 Free PMC article.
• Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma.
  Kew MC. Kew MC. J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:144-52. doi: 10.1111/j.1440-1746.2010.06546.x. J Gastroenterol Hepatol. 2011. PMID: 21199526 Review.
• Hepatocarcinogenesis in viral Hepatitis B infection: the role of HBx and p53.
  Dewantoro O, Gani RA, Akbar N. Dewantoro O, et al. Acta Med Indones. 2006 Jul-Sep;38(3):154-9. Acta Med Indones. 2006. PMID: 16953033 Review.

Cited by

• Rotavirus-encoded nonstructural protein 1 modulates cellular apoptotic machinery by targeting tumor suppressor protein p53.
  Bhowmick R, Halder UC, Chattopadhyay S, Nayak MK, Chawla-Sarkar M. Bhowmick R, et al. J Virol. 2013 Jun;87(12):6840-50. doi: 10.1128/JVI.00734-13. Epub 2013 Apr 10. J Virol. 2013. PMID: 23576507 Free PMC article.
• Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma.
  Pawlik TM, Poon RT, Abdalla EK, Sarmiento JM, Ikai I, Curley SA, Nagorney DM, Belghiti J, Ng IO, Yamaoka Y, Lauwers GY, Vauthey JN. Pawlik TM, et al. J Gastrointest Surg. 2004 Nov;8(7):794-804; discussion 804-5. doi: 10.1016/j.gassur.2004.06.013. J Gastrointest Surg. 2004. PMID: 15531232
• Viral hepatocarcinogenesis.
  Tsai WL, Chung RT. Tsai WL, et al. Oncogene. 2010 Apr 22;29(16):2309-24. doi: 10.1038/onc.2010.36. Epub 2010 Mar 15. Oncogene. 2010. PMID: 20228847 Free PMC article. Review.
• RNAi for treating hepatitis B viral infection.
  Chen Y, Cheng G, Mahato RI. Chen Y, et al. Pharm Res. 2008 Jan;25(1):72-86. doi: 10.1007/s11095-007-9504-0. Epub 2007 Dec 12. Pharm Res. 2008. PMID: 18074201 Free PMC article. Review.
• Dysregulation of Liver Regeneration by Hepatitis B Virus Infection: Impact on Development of Hepatocellular Carcinoma.
  Park ES, Dezhbord M, Lee AR, Park BB, Kim KH. Park ES, et al. Cancers (Basel). 2022 Jul 22;14(15):3566. doi: 10.3390/cancers14153566. Cancers (Basel). 2022. PMID: 35892823 Free PMC article. Review.

References

1. 1. Gene. 1988 Jul 15;67(1):31-40 - PubMed
2. 1. Nature. 1992 Jul 2;358(6381):80-3 - PubMed
3. 1. Cell. 1990 Nov 16;63(4):687-95 - PubMed
4. 1. Nature. 1979 Mar 15;278(5701):261-3 - PubMed
5. 1. Nat Genet. 1993 May;4(1):42-6 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Research Materials

  • Addgene Non-profit plasmid repository
  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal