Sequence and structure comparison suggest that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold - PubMed (original) (raw)

Comparative Study

Sequence and structure comparison suggest that methionine aminopeptidase, prolidase, aminopeptidase P, and creatinase share a common fold

J F Bazan et al. Proc Natl Acad Sci U S A. 1994.

Abstract

Amino acid sequence comparison suggests that the structure of Escherichia coli methionine aminopeptidase (EC 3.4.11.18) and the C-terminal domain of Pseudomonas putida creatinase (EC 3.5.3.3) are related. A detailed comparison of the three-dimensional folds of the two enzymes confirms this homology: with an approximately 260-residue chain segment, 218 C alpha atoms of the structures superimpose within 2.5 A; only 41 of these overlapping positions (i.e., 19%) feature identical amino acids in the two protein chains. Notwithstanding this striking correspondence in structure, methionine aminopeptidase binds and is stimulated by Co2+, while creatinase is not a metal-dependent enzyme. Searches of protein data banks using sequence and structure-based profiles reveal other enzymes, including aminopeptidase P (EC 3.4.11.9), prolidase (EC 3.4.13.9), and agropine synthase, that likely share the same "pita-bread" fold common to creatinase and methionine aminopeptidase.

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References

1. 1. J Mol Biol. 1976 Jul 25;105(1):75-95 - PubMed
2. 1. Biochemistry. 1993 Apr 20;32(15):3907-12 - PubMed
3. 1. Methods Enzymol. 1985;115:397-420 - PubMed
4. 1. EMBO J. 1986 Apr;5(4):823-6 - PubMed
5. 1. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4355-8 - PubMed

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