Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc - PubMed (original) (raw)
Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc
G Fischer et al. J Exp Med. 1994.
Abstract
Treatment of the WEHI-2131 or CH31 B cell lymphomas with anti-mu or transforming growth factor (TGF)-beta leads to growth inhibition and subsequent cell death via apoptosis. Since anti-mu stimulates a transient increase in c-myc and c-fos transcription in these lymphomas, we examined the role of these proteins in growth regulation using antisense oligonucleotides. Herein, we demonstrate that antisense oligonucleotides for c-myc prevent both anti-mu- and TGF-beta-mediated growth inhibition in the CH31 and WEHI-231 B cell lymphomas, whereas antisense c-fos has no effect. Furthermore, antisense c-myc promotes the appearance of phosphorylated retinoblastoma protein in the presence of anti-mu and prevents the progression to apoptosis as measured by propidium iodide staining. Northern and Western analyses show that c-myc message and the levels of multiple myc proteins were maintained in the presence of antisense c-myc, results indicating that myc species are critical for the continuation of proliferation and the prevention of apoptosis. These data implicate c-myc in the negative signaling pathway of both TGF-beta and anti-mu.
Similar articles
- Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Yao XR, Scott DW. Yao XR, et al. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7946-50. doi: 10.1073/pnas.90.17.7946. Proc Natl Acad Sci U S A. 1993. PMID: 7690139 Free PMC article. - Life and death decisions in B1 lymphoma cells.
Donjerković D, Carey GB, Mueller CM, Liu S, Scott DW. Donjerković D, et al. Curr Top Microbiol Immunol. 2000;252:151-9. doi: 10.1007/978-3-642-57284-5_16. Curr Top Microbiol Immunol. 2000. PMID: 11187083 - Role of c-myc and p27 in anti-IgM induced B-lymphoma apoptosis.
Scott DW, Donjerković D, Maddox B, Ezhevsky S, Grdina T. Scott DW, et al. Curr Top Microbiol Immunol. 1997;224:103-12. doi: 10.1007/978-3-642-60801-8_10. Curr Top Microbiol Immunol. 1997. PMID: 9308233 Review.
Cited by
- Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF.
Chau CM, Zhang XY, McMahon SB, Lieberman PM. Chau CM, et al. J Virol. 2006 Jun;80(12):5723-32. doi: 10.1128/JVI.00025-06. J Virol. 2006. PMID: 16731911 Free PMC article. - c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells.
Gururajan M, Chui R, Karuppannan AK, Ke J, Jennings CD, Bondada S. Gururajan M, et al. Blood. 2005 Aug 15;106(4):1382-91. doi: 10.1182/blood-2004-10-3819. Epub 2005 May 12. Blood. 2005. PMID: 15890690 Free PMC article. - CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells.
Qi CF, Martensson A, Mattioli M, Dalla-Favera R, Lobanenkov VV, Morse HC 3rd. Qi CF, et al. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):633-8. doi: 10.1073/pnas.0237127100. Epub 2003 Jan 10. Proc Natl Acad Sci U S A. 2003. PMID: 12524457 Free PMC article. - Glucocorticoid mediated transcriptional repression of c-myc in apoptotic human leukemic CEM cells.
Zhou F, Medh RD, Thompson EB. Zhou F, et al. J Steroid Biochem Mol Biol. 2000 Jul-Aug;73(5):195-202. doi: 10.1016/s0960-0760(00)00080-7. J Steroid Biochem Mol Biol. 2000. PMID: 11070348 Free PMC article. - Antigen receptor signalling in apoptosis-resistant mutants of WEHI 231 cells.
Tasker L, Marshall-Clarke S. Tasker L, et al. Immunology. 2000 Mar;99(3):385-93. doi: 10.1046/j.1365-2567.2000.00976.x. Immunology. 2000. PMID: 10712668 Free PMC article.
References
- Nature. 1992 Nov 12;360(6400):177-9 - PubMed
- Cell Growth Differ. 1992 May;3(5):291-8 - PubMed
- Nature. 1993 Apr 29;362(6423):847-9 - PubMed
- Proc Natl Acad Sci U S A. 1984 Sep;81(17):5546-50 - PubMed
- Nature. 1992 Oct 8;359(6395):552-4 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials