Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes - PubMed (original) (raw)

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes

M Tyers et al. Mol Cell Biol. 1993 Sep.

Erratum in

• Mol Cell Biol 1994 Mar;14(3):2222

Abstract

In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This induced interaction depends upon the Fus3 protein kinase, a mitogen-activated protein kinase homolog that functions near the bottom of the alpha-factor signal transduction pathway. Thus, we trace a path through which a mitogen-activated protein kinase regulates a Cdc2 kinase.

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References

1. 1. Cell. 1989 Dec 22;59(6):1127-33 - PubMed
2. 1. Cell. 1989 Sep 22;58(6):1107-19 - PubMed
3. 1. Genetics. 1990 Feb;124(2):275-82 - PubMed
4. 1. Genes Dev. 1990 Apr;4(4):492-502 - PubMed
5. 1. Science. 1990 Jul 6;249(4964):64-7 - PubMed

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