Antibodies against microglia/brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia - PubMed (original) (raw)
Case Reports
. 1995 Jul-Aug;14(4):197-200.
Affiliations
- PMID: 8521621
Case Reports
Antibodies against microglia/brain macrophages in the cerebrospinal fluid of a patient with acute amyotrophic lateral sclerosis and presenile dementia
R B Banati et al. Clin Neuropathol. 1995 Jul-Aug.
Abstract
This is the report of a case of a 41-year-old male patient with a rapidly progressing amyotrophic lateral sclerosis (ALS) combined with a severe presenile dementia. Screening for antibody binding on fresh-frozen human brain sections, we found that the patient's cerebrospinal fluid contained antibodies against microglia, the dominant and potentially cytotoxic immuneffector cell of the brain. This finding extends previous observations of CSF autoantibodies against microglia in neurodegenerative diseases. It demonstrates that in addition to antigens of neuronal origin (e.g. anti-Purkinje cell antibodies in paraneoplastic cerebellar dysfunction), glial antigens also appear to be under the surveillance of the CNS and/or the peripheral immune system. Our data provide evidence for a close link between neurodegeneration and the activation of microglia; a possible local antigen production against microglia/brain macrophages, which might regulate the concomitant glial activation in neurodegenerative diseases; and the presence of microglia-binding cerebrospinal antibodies as a marker for the acuity of the disease process underlying the acute deterioration of the neurological and cognitive performance in patients with, e.g., ALS. Future therapeutic strategies could therefore include the modulation of the possibly disease-promoting activation of microglia/brain macrophages.
Similar articles
- Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.
Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH. Henkel JS, et al. Ann Neurol. 2004 Feb;55(2):221-35. doi: 10.1002/ana.10805. Ann Neurol. 2004. PMID: 14755726 - Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.
Wiendl H, Feger U, Mittelbronn M, Jack C, Schreiner B, Stadelmann C, Antel J, Brueck W, Meyermann R, Bar-Or A, Kieseier BC, Weller M. Wiendl H, et al. Brain. 2005 Nov;128(Pt 11):2689-704. doi: 10.1093/brain/awh609. Epub 2005 Aug 25. Brain. 2005. PMID: 16123145 - Erythropoietin in the cerebrospinal fluid in neurodegenerative diseases.
Brettschneider J, Widl K, Ehrenreich H, Riepe M, Tumani H. Brettschneider J, et al. Neurosci Lett. 2006 Sep 1;404(3):347-51. doi: 10.1016/j.neulet.2006.06.011. Epub 2006 Jul 3. Neurosci Lett. 2006. PMID: 16815630 - Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions.
McGeer PL, McGeer EG. McGeer PL, et al. Alzheimer Dis Assoc Disord. 1998;12 Suppl 2:S1-6. Alzheimer Dis Assoc Disord. 1998. PMID: 9769023 Review. - Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis.
Sargsyan SA, Monk PN, Shaw PJ. Sargsyan SA, et al. Glia. 2005 Sep;51(4):241-53. doi: 10.1002/glia.20210. Glia. 2005. PMID: 15846792 Review.
Cited by
- Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia.
Eshraghi M, Adlimoghaddam A, Mahmoodzadeh A, Sharifzad F, Yasavoli-Sharahi H, Lorzadeh S, Albensi BC, Ghavami S. Eshraghi M, et al. Int J Mol Sci. 2021 Mar 24;22(7):3330. doi: 10.3390/ijms22073330. Int J Mol Sci. 2021. PMID: 33805142 Free PMC article. Review. - A case of GABAR antibodies in schizophrenia.
Haussleiter IS, Wandinger KP, Juckel G. Haussleiter IS, et al. BMC Psychiatry. 2017 Jan 10;17(1):9. doi: 10.1186/s12888-016-1157-2. BMC Psychiatry. 2017. PMID: 28068943 Free PMC article. - Microglial activation and chronic neurodegeneration.
Lull ME, Block ML. Lull ME, et al. Neurotherapeutics. 2010 Oct;7(4):354-65. doi: 10.1016/j.nurt.2010.05.014. Neurotherapeutics. 2010. PMID: 20880500 Free PMC article. - Involvement of quinolinic acid in AIDS dementia complex.
Guillemin GJ, Kerr SJ, Brew BJ. Guillemin GJ, et al. Neurotox Res. 2005;7(1-2):103-23. doi: 10.1007/BF03033781. Neurotox Res. 2005. PMID: 15639803 Review. - Inhibition of microglia activation as a phenotypic assay in early drug discovery.
Figuera-Losada M, Rojas C, Slusher BS. Figuera-Losada M, et al. J Biomol Screen. 2014 Jan;19(1):17-31. doi: 10.1177/1087057113499406. Epub 2013 Aug 14. J Biomol Screen. 2014. PMID: 23945875 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous