Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization - PubMed (original) (raw)
Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization
E Schröck et al. Genes Chromosomes Cancer. 1996 Apr.
Abstract
Consistent tumor-specific chromosomal aberrations have not been described in low-grade astrocytic tumors. The most frequent genetic alterations are mutations of the TP53 tumor suppressor gene and/or loss of heterozygosity (LOH) on 17p that occur in about 30% of the cases in adult patients but that are uncommon in childhood tumors. We used comparative genomic hybridization (CGH) to map DNA copy number alterations in 18 primary low-grade astrocytic tumors (ten adult patients and eight children). A gain of chromosome arm 7q was the most frequent event detected in five of ten astrocytomas (50%) from adult patients, followed by DNA amplification on chromosome arm 8q and gain on 12p (two cases). Loss of chromosomal regions on 1p, 4q, and the X chromosome was observed in two of ten cases [including one patient afflicted with Turner syndrome (45,X)]. In contrast, no consistent changes were observed in low-grade astrocytomas in children. A loss of the X chromosome was the sole aberration detected in two of eight cases using DNA extracted from the normal brain tissue. The findings suggest that a gain of 7q is an early event in the initiation of astrocytomas in adult patients. The discrepant findings in low-grade astrocytic tumors in adults compared to tumors in children support the the hypothesis that there might be different mechanisms responsible for tumor development.
Similar articles
- Chromosomal imbalances detected by array comparative genomic hybridization in human oligodendrogliomas and mixed oligoastrocytomas.
Kitange G, Misra A, Law M, Passe S, Kollmeyer TM, Maurer M, Ballman K, Feuerstein BG, Jenkins RB. Kitange G, et al. Genes Chromosomes Cancer. 2005 Jan;42(1):68-77. doi: 10.1002/gcc.20108. Genes Chromosomes Cancer. 2005. PMID: 15472895 - Genetic subgroups of anaplastic astrocytomas correlate with patient age and survival.
Kunwar S, Mohapatra G, Bollen A, Lamborn KR, Prados M, Feuerstein BG. Kunwar S, et al. Cancer Res. 2001 Oct 15;61(20):7683-8. Cancer Res. 2001. PMID: 11606412 - Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization.
Nishizaki T, Ozaki S, Harada K, Ito H, Arai H, Beppu T, Sasaki K. Nishizaki T, et al. Genes Chromosomes Cancer. 1998 Apr;21(4):340-6. doi: 10.1002/(sici)1098-2264(199804)21:4<340::aid-gcc8>3.0.co;2-z. Genes Chromosomes Cancer. 1998. PMID: 9559346 Review. - [Chromosome abnormalities and adenine metabolism in human glial tumors].
Bardot V, Dutrillaux AM, Luccioni C, Poisson M, Delattre JY, Vega F, Dutrillaux B. Bardot V, et al. Rev Neurol (Paris). 1992;148(6-7):408-16. Rev Neurol (Paris). 1992. PMID: 1448660 Review. French.
Cited by
- Spectral imaging to visualize higher-order genomic organization.
Sawyer IA, Shevtsov SP, Dundr M. Sawyer IA, et al. Nucleus. 2016 May 3;7(3):325-38. doi: 10.1080/19491034.2016.1187344. Epub 2016 May 11. Nucleus. 2016. PMID: 27167405 Free PMC article. - The molecular biology of WHO grade I astrocytomas.
Marko NF, Weil RJ. Marko NF, et al. Neuro Oncol. 2012 Dec;14(12):1424-31. doi: 10.1093/neuonc/nos257. Epub 2012 Oct 22. Neuro Oncol. 2012. PMID: 23090984 Free PMC article. Review. - MET gain in diffuse astrocytomas is associated with poorer outcome.
Pierscianek D, Kim YH, Motomura K, Mittelbronn M, Paulus W, Brokinkel B, Keyvani K, Wrede K, Nakazato Y, Tanaka Y, Mariani L, Vital A, Sure U, Ohgaki H. Pierscianek D, et al. Brain Pathol. 2013 Jan;23(1):13-8. doi: 10.1111/j.1750-3639.2012.00609.x. Epub 2012 Jul 3. Brain Pathol. 2013. PMID: 22672415 Free PMC article. - Long-term epilepsy-associated tumors.
Thom M, Blümcke I, Aronica E. Thom M, et al. Brain Pathol. 2012 May;22(3):350-79. doi: 10.1111/j.1750-3639.2012.00582.x. Brain Pathol. 2012. PMID: 22497610 Free PMC article. Review. - MAPK pathway activation in pilocytic astrocytoma.
Jones DT, Gronych J, Lichter P, Witt O, Pfister SM. Jones DT, et al. Cell Mol Life Sci. 2012 Jun;69(11):1799-811. doi: 10.1007/s00018-011-0898-9. Epub 2011 Dec 13. Cell Mol Life Sci. 2012. PMID: 22159586 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous