The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid 335 of the hemagglutinin-neuraminidase gene with one form associated with disease - PubMed (original) (raw)
Comparative Study
. 1996 Sep;174(3):619-22.
doi: 10.1093/infdis/174.3.619.
Affiliations
- PMID: 8769623
- DOI: 10.1093/infdis/174.3.619
Comparative Study
The Urabe AM9 mumps vaccine is a mixture of viruses differing at amino acid 335 of the hemagglutinin-neuraminidase gene with one form associated with disease
E G Brown et al. J Infect Dis. 1996 Sep.
Abstract
The reason for the high incidence of vaccine-associated meningitis due to the Urabe AM9 vaccine was assessed by comparing the nucleotide (nt) sequence of the hemagglutinin-neuraminidase (HN) gene from vaccine virus to those of viruses isolated from persons with postvaccination meningitis. A G1081--> A nt substitution that was predicted to result in a Glu335--> Lys reversion in the HN protein was detected between Urabe AM9 (G) and postvaccine meningitis mumps virus isolates (A). Further analysis showed that the Urabe AM9 vaccine was a mixture of viruses with wild type (A) and variant (G) nt at position 1081. Urabe AM9 vaccinees who developed meningitis or parotitis possessed predominantly A (98%-100%) at nt 1081, indicating strong selection of the wild type (A) form relative to the variant (G) form. Mumps virus homogeneous for the variant Glu335 form of the HN gene may be safer than the original Urabe AM9 vaccine.
Comment in
- Nucleotide sequence at position 1081 of the hemagglutinin-neuraminidase gene in the mumps virus Urabe vaccine strain.
Mori C, Tooriyama T, Imagawa T, Yamanishi K. Mori C, et al. J Infect Dis. 1997 Jun;175(6):1548-9. doi: 10.1086/516499. J Infect Dis. 1997. PMID: 9180205 No abstract available. - Nucleotide sequence at position 1081 of the hemagglutinin-neuraminidase gene in the mumps Urabe vaccine strain.
Afzal MA, Yates PJ, Minor PD. Afzal MA, et al. J Infect Dis. 1998 Jan;177(1):265-6. doi: 10.1086/517353. J Infect Dis. 1998. PMID: 9419205 No abstract available.
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