Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM - PubMed (original) (raw)

. 1996 Aug 23;225(3):1035-9.

doi: 10.1006/bbrc.1996.1290.

Affiliations

• PMID: 8780729
• DOI: 10.1006/bbrc.1996.1290

Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM

T Takeshita et al. Biochem Biophys Res Commun. 1996.

Abstract

We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.

PubMed Disclaimer

Similar articles

• Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
  Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A. Yokouchi M, et al. Oncogene. 1997 Jul 3;15(1):7-15. doi: 10.1038/sj.onc.1201163. Oncogene. 1997. PMID: 9233773
• STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction.
  Takeshita T, Arita T, Higuchi M, Asao H, Endo K, Kuroda H, Tanaka N, Murata K, Ishii N, Sugamura K. Takeshita T, et al. Immunity. 1997 Apr;6(4):449-57. doi: 10.1016/s1074-7613(00)80288-5. Immunity. 1997. PMID: 9133424
• Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways.
  Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF. Pandey A, et al. J Biol Chem. 2000 Dec 8;275(49):38633-9. doi: 10.1074/jbc.M007849200. J Biol Chem. 2000. PMID: 10993906
• The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking.
  Wang T, Liu NS, Seet LF, Hong W. Wang T, et al. Traffic. 2010 Sep;11(9):1119-28. doi: 10.1111/j.1600-0854.2010.01098.x. Epub 2010 Jul 1. Traffic. 2010. PMID: 20604899 Review.
• STAM/EAST/Hbp adapter proteins--integrators of signalling pathways.
  Lohi O, Lehto VP. Lohi O, et al. FEBS Lett. 2001 Nov 23;508(3):287-90. doi: 10.1016/s0014-5793(01)03079-4. FEBS Lett. 2001. PMID: 11728436 Review.

Cited by

• Cargo- and compartment-selective endocytic scaffold proteins.
  Szymkiewicz I, Shupliakov O, Dikic I. Szymkiewicz I, et al. Biochem J. 2004 Oct 1;383(Pt 1):1-11. doi: 10.1042/BJ20040913. Biochem J. 2004. PMID: 15219178 Free PMC article. Review.
• Role of bacterial infections in extracellular vesicles release and impact on immune response.
  Spencer N, Yeruva L. Spencer N, et al. Biomed J. 2021 Apr;44(2):157-164. doi: 10.1016/j.bj.2020.05.006. Epub 2020 May 23. Biomed J. 2021. PMID: 32888911 Free PMC article. Review.
• Evolution and origin of HRS, a protein interacting with Merlin, the Neurofibromatosis 2 gene product.
  Omelyanchuk LV, Pertseva JA, Burns SS, Chang LS. Omelyanchuk LV, et al. Gene Regul Syst Bio. 2009 Oct 8;3:143-57. doi: 10.4137/grsb.s3106. Gene Regul Syst Bio. 2009. PMID: 20054405 Free PMC article.
• STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif.
  Mizuno E, Kawahata K, Kato M, Kitamura N, Komada M. Mizuno E, et al. Mol Biol Cell. 2003 Sep;14(9):3675-89. doi: 10.1091/mbc.e02-12-0823. Epub 2003 Jun 13. Mol Biol Cell. 2003. PMID: 12972556 Free PMC article.
• A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis.
  Chanut-Delalande H, Jung AC, Lin L, Baer MM, Bilstein A, Cabernard C, Leptin M, Affolter M. Chanut-Delalande H, et al. Genetics. 2007 Aug;176(4):2177-87. doi: 10.1534/genetics.107.073890. Epub 2007 Jul 1. Genetics. 2007. PMID: 17603108 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)

• Research Materials

  • National BioResource Project

• Miscellaneous

  • NCI CPTAC Assay Portal