RCC1 in the Ran pathway - PubMed (original) (raw)
Review
RCC1 in the Ran pathway
T Seki et al. J Biochem. 1996 Aug.
Free article
Abstract
RCC1 is a chromosomal protein that functions as a GEF of the nuclear G protein Ran, which GTPase activity is enhanced by RNA1 located in the cytoplasm. RCC1 has no preference for GTP or GDP-bound Ran, so that GTP-Ran formation in vivo is regulated by relative concentrations of GTP/GDP and regulatory proteins interacting with RCC1, Ran, and RNA1. Proteins possessing the special Ran-binding motif have been found to be conserved in species ranging from yeasts to mammalians. The finding of RanBP2/NUP358 clearly indicates the involvement of the Ran pathway in the nuclear pore transport function, in agreement with the finding that both rcc1- and rna1- show defects in this process. However, loss of RCC1 induces premature initiation of mitosis, resulting in G1 arrest with the micronuclei possessing mitotic condensed chromosomes. How both the cell cycle and nucleocytoplasmic transport are regulated by the RCC1-Ran pathway is a major question.
Similar articles
- Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1.
Noguchi E, Hayashi N, Azuma Y, Seki T, Nakamura M, Nakashima N, Yanagida M, He X, Mueller U, Sazer S, Nishimoto T. Noguchi E, et al. EMBO J. 1996 Oct 15;15(20):5595-605. EMBO J. 1996. PMID: 8896453 Free PMC article. - RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae.
Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A. Becker J, et al. J Biol Chem. 1995 May 19;270(20):11860-5. doi: 10.1074/jbc.270.20.11860. J Biol Chem. 1995. PMID: 7744835 - Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.
Klebe C, Bischoff FR, Ponstingl H, Wittinghofer A. Klebe C, et al. Biochemistry. 1995 Jan 17;34(2):639-47. doi: 10.1021/bi00002a031. Biochemistry. 1995. PMID: 7819259 - Nucleocytoplasmic transport: driving and directing transport.
Cole CN, Hammell CM. Cole CN, et al. Curr Biol. 1998 May 21;8(11):R368-72. doi: 10.1016/s0960-9822(98)70239-8. Curr Biol. 1998. PMID: 9635180 Review. - A new role of ran GTPase.
Nishimoto T. Nishimoto T. Biochem Biophys Res Commun. 1999 Sep 7;262(3):571-4. doi: 10.1006/bbrc.1999.1252. Biochem Biophys Res Commun. 1999. PMID: 10471364 Review.
Cited by
- Disruption of the ran system by cysteine oxidation of the nucleotide exchange factor RCC1.
Chatterjee M, Paschal BM. Chatterjee M, et al. Mol Cell Biol. 2015 Feb;35(3):566-81. doi: 10.1128/MCB.01133-14. Epub 2014 Dec 1. Mol Cell Biol. 2015. PMID: 25452301 Free PMC article. - Spatial cycles in G-protein crowd control.
Vartak N, Bastiaens P. Vartak N, et al. EMBO J. 2010 Aug 18;29(16):2689-99. doi: 10.1038/emboj.2010.184. EMBO J. 2010. PMID: 20717139 Free PMC article. Review. - Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus.
Czigleczki J, de Resende Lara PT, Dudas B, Jang H, Perahia D, Nussinov R, Balog E. Czigleczki J, et al. Front Mol Biosci. 2023 Jan 16;10:1111574. doi: 10.3389/fmolb.2023.1111574. eCollection 2023. Front Mol Biosci. 2023. PMID: 36726377 Free PMC article. - Targeting guanine nucleotide exchange factors for novel cancer drug discovery.
Bannoura SF, Khan HY, Uddin MH, Mohammad RM, Pasche BC, Azmi AS. Bannoura SF, et al. Expert Opin Drug Discov. 2024 Aug;19(8):949-959. doi: 10.1080/17460441.2024.2368242. Epub 2024 Jun 17. Expert Opin Drug Discov. 2024. PMID: 38884380 Review. - Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.
Plafker K, Macara IG. Plafker K, et al. Mol Cell Biol. 2000 May;20(10):3510-21. doi: 10.1128/MCB.20.10.3510-3521.2000. Mol Cell Biol. 2000. PMID: 10779340 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous