Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development - PubMed (original) (raw)
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
F Maina et al. Cell. 1996.
Free article
Abstract
Hepatocyte growth factor (HGF) and its receptor, the Met tyrosine kinase, are determinants of placenta, liver, and muscle development. Here, we show that Met function in vivo requires signaling via two carboxy-terminal tyrosines. Mutation of both residues in the mouse genome caused embryonal death, with placenta, liver, and limb muscle defects, mimicking the phenotype of met null mutants. In contrast, disrupting the consensus for Grb2 binding allowed development to proceed to term without affecting placenta and liver but caused a striking reduction in limb muscle coupled to a generalized deficit of secondary fibers. These data show that the requirements for Met signaling vary depending on the tissue and reveal a novel role for HGF/ Met in late myogenesis.
Similar articles
- Preferential binding of Grb2 or phosphatidylinositol 3-kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation.
Leshem Y, Gitelman I, Ponzetto C, Halevy O. Leshem Y, et al. Exp Cell Res. 2002 Apr 1;274(2):288-98. doi: 10.1006/excr.2002.5473. Exp Cell Res. 2002. PMID: 11900489 - Efficient cell transformation by the Tpr-Met oncoprotein is dependent upon tyrosine 489 in the carboxy-terminus.
Fixman ED, Naujokas MA, Rodrigues GA, Moran MF, Park M. Fixman ED, et al. Oncogene. 1995 Jan 19;10(2):237-49. Oncogene. 1995. PMID: 7838524 - Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility.
Ponzetto C, Zhen Z, Audero E, Maina F, Bardelli A, Basile ML, Giordano S, Narsimhan R, Comoglio P. Ponzetto C, et al. J Biol Chem. 1996 Jun 14;271(24):14119-23. doi: 10.1074/jbc.271.24.14119. J Biol Chem. 1996. PMID: 8662889 - Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene.
Vigna E, Naldini L, Tamagnone L, Longati P, Bardelli A, Maina F, Ponzetto C, Comoglio PM. Vigna E, et al. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):597-604. Cell Mol Biol (Noisy-le-grand). 1994. PMID: 7981617 Review. - Hepatocyte growth factor as mitogen, motogen and morphogen, and its roles in organ regeneration.
Nakamura T. Nakamura T. Princess Takamatsu Symp. 1994;24:195-213. Princess Takamatsu Symp. 1994. PMID: 8983076 Review.
Cited by
- Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm.
Sefton EM, Gallardo M, Tobin CE, Collins BC, Colasanto MP, Merrell AJ, Kardon G. Sefton EM, et al. Elife. 2022 Sep 26;11:e74592. doi: 10.7554/eLife.74592. Elife. 2022. PMID: 36154712 Free PMC article. - Redundant roles for Met docking site tyrosines and the Gab1 pleckstrin homology domain in InlB-mediated entry of Listeria monocytogenes.
Basar T, Shen Y, Ireton K. Basar T, et al. Infect Immun. 2005 Apr;73(4):2061-74. doi: 10.1128/IAI.73.4.2061-2074.2005. Infect Immun. 2005. PMID: 15784547 Free PMC article. - Combinatorial ShcA docking interactions support diversity in tissue morphogenesis.
Hardy WR, Li L, Wang Z, Sedy J, Fawcett J, Frank E, Kucera J, Pawson T. Hardy WR, et al. Science. 2007 Jul 13;317(5835):251-6. doi: 10.1126/science.1140114. Science. 2007. PMID: 17626887 Free PMC article. - Invasive growth: from development to metastasis.
Comoglio PM, Trusolino L. Comoglio PM, et al. J Clin Invest. 2002 Apr;109(7):857-62. doi: 10.1172/JCI15392. J Clin Invest. 2002. PMID: 11927611 Free PMC article. Review. No abstract available. - When the MET receptor kicks in to resist targeted therapies.
Fernandes M, Jamme P, Cortot AB, Kherrouche Z, Tulasne D. Fernandes M, et al. Oncogene. 2021 Jun;40(24):4061-4078. doi: 10.1038/s41388-021-01835-0. Epub 2021 May 24. Oncogene. 2021. PMID: 34031544 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous