The clinical significance of androgen receptors in breast cancer and their relation to histological and cell biological parameters - PubMed (original) (raw)
The clinical significance of androgen receptors in breast cancer and their relation to histological and cell biological parameters
V Kuenen-Boumeester et al. Eur J Cancer. 1996 Aug.
Free article
Abstract
To analyse the clinical significance of the presence of androgen receptors (AR) in breast carcinomas, clinical and histological parameters of 153 primary breast carcinomas (median follow-up 46 months) were examined. Oestrogen (ER) and progesterone receptor (PR) levels were determined in cytosol preparations using enzyme immunoassay assays and in cryostat sections by immunohistochemistry. AR and Ki-67 levels were only determined immunohistochemically. Data were analysed by uni- and multivariate models. 94/153 (61%) breast carcinomas were ER+ PR+ AR+, while 14 cases were only positive for AR. All grade III tumours (n = 17) were steroid receptor negative and 14 (76%) of these cases demonstrated high Ki-67 values suggestive of more aggressive behaviour. Strikingly, 14 ductal carcinomas negative for ER and PR were positive for AR. In univariate analysis, AR as well as ER, tumour size, lymph node status, grade and Ki-67 proved to be significant prognostic factors for disease-free survival (DFS). Multivariate analysis, however, showed lymph node status, tumour size and ER status to be the only independent prognostic factors for DFS within this model. We conclude that simple histological and cell biological parameters, including AR, can be used to select high- and low-risk patients at the time of primary surgery and can provide valuable information on treatment options.
Similar articles
- Androgen receptor expression in a Sri Lankan patient cohort with early breast carcinoma.
Wijesinghe HD, Wijesinghe GK, Mansoor Z, Vigneshwara S, Fernando J, Gunasekera D, Lokuhetty MDS. Wijesinghe HD, et al. BMC Womens Health. 2020 Sep 14;20(1):206. doi: 10.1186/s12905-020-01068-5. BMC Womens Health. 2020. PMID: 32928183 Free PMC article. - Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity.
Lin Fde M, Pincerato KM, Bacchi CE, Baracat EC, Carvalho FM. Lin Fde M, et al. J Clin Pathol. 2012 Jan;65(1):64-8. doi: 10.1136/jclinpath-2011-200318. Epub 2011 Oct 29. J Clin Pathol. 2012. PMID: 22039288 - Expression of androgen receptor in primary breast carcinoma and its relation with clinicopathologic features, estrogen, progesterone, and her-2 receptor status.
Vellaisamy G, Tirumalae R, Inchara YK. Vellaisamy G, et al. J Cancer Res Ther. 2019 Jul-Sep;15(5):989-993. doi: 10.4103/jcrt.JCRT_572_17. J Cancer Res Ther. 2019. PMID: 31603099 - Hormone receptors in breast cancer: more than estrogen receptors.
Lamb CA, Vanzulli SI, Lanari C. Lamb CA, et al. Medicina (B Aires). 2019;79(Spec 6/1):540-545. Medicina (B Aires). 2019. PMID: 31864223 Review. English.
Cited by
- Prevalence of Androgen Receptor in Invasive Breast Cancer and Its Association with Clinicopathologic Features in East Azarbaijan Province of Iran: A Cross-Sectional Study.
Nikanfar A, Nikanfar M, Fakhrjou A. Nikanfar A, et al. Int J Hematol Oncol Stem Cell Res. 2023 Jul 1;17(3):186-193. doi: 10.18502/ijhoscr.v17i3.13308. Int J Hematol Oncol Stem Cell Res. 2023. PMID: 37817975 Free PMC article. - Racial Disparity in Quadruple Negative Breast Cancer: Aggressive Biology and Potential Therapeutic Targeting and Prevention.
Jinna N, Jovanovic-Talisman T, LaBarge M, Natarajan R, Kittles R, Sistrunk C, Rida P, Seewaldt VL. Jinna N, et al. Cancers (Basel). 2022 Sep 16;14(18):4484. doi: 10.3390/cancers14184484. Cancers (Basel). 2022. PMID: 36139643 Free PMC article. Review. - Androgen receptor in breast cancer: The "5W" questions.
Ravaioli S, Maltoni R, Pasculli B, Parrella P, Giudetti AM, Vergara D, Tumedei MM, Pirini F, Bravaccini S. Ravaioli S, et al. Front Endocrinol (Lausanne). 2022 Aug 30;13:977331. doi: 10.3389/fendo.2022.977331. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36111296 Free PMC article. Review. - Androgen Receptor as a Predictive Marker for Pathologic Complete Response in Hormone Receptor-Positive and HER-2-Negative Breast Cancer with Neoadjuvant Chemotherapy.
Lee EG, Lee DE, Kim HH, Han JH, Lee S, Kang HS, Lee ES, Chae H, Sim SH, Lee KS, Kwon Y, Jung SY. Lee EG, et al. Cancer Res Treat. 2023 Apr;55(2):542-550. doi: 10.4143/crt.2022.834. Epub 2022 Sep 8. Cancer Res Treat. 2023. PMID: 36097802 Free PMC article. - QNBC Is Associated with High Genomic Instability Characterized by Copy Number Alterations and miRNA Deregulation.
Bhattarai S, Sugita BM, Bortoletto SM, Fonseca AS, Cavalli LR, Aneja R. Bhattarai S, et al. Int J Mol Sci. 2021 Oct 26;22(21):11548. doi: 10.3390/ijms222111548. Int J Mol Sci. 2021. PMID: 34768979 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials