Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis - PubMed (original) (raw)
Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis
I B McInnes et al. Nat Med. 1997 Feb.
Abstract
Tumor necrosis factor-alpha occupies a central role in rheumatoid arthritis (RA) pathogenesis. We now report that interleukin-15 (IL-15) can induce TNF-alpha production in RA through activation of synovial T cells. Peripheral blood (PB) T cells activated by IL-15 induced significant TNF-alpha production by macrophages via a cell-contact-dependent mechanism. Freshly isolated RA synovial T cells possessed similar capability, and in vitro, IL-15 was necessary to maintain this activity. IL-15 also induced direct TNF-alpha production by synovial T cells. In contrast, IL-2 induced significantly lower TNF-alpha production in either cell-contact-dependent or direct culture, and IL-8 and MIP-1 alpha were ineffective. Antibodies against CD69, LFA-1 or ICAM-1 significantly inhibited the ability of T cells to activate macrophages by cell contact.
Comment in
- Unconventional T-cell activation by IL-15 in rheumatoid arthritis.
Carson DA. Carson DA. Nat Med. 1997 Feb;3(2):148-9. doi: 10.1038/nm0297-148. Nat Med. 1997. PMID: 9018227 No abstract available. - A role for IL-15 in rheumatoid arthritis?
Shah MH, Hackshaw KV, Caligiuri MA. Shah MH, et al. Nat Med. 1998 Jun;4(6):643. doi: 10.1038/nm0698-643a. Nat Med. 1998. PMID: 9623950 No abstract available.
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