Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression - PubMed (original) (raw)

. 1997 May 1;387(6628):49-55.

doi: 10.1038/387049a0.

Affiliations

• PMID: 9139821
• DOI: 10.1038/387049a0

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

L Alland et al. Nature. 1997.

Abstract

Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.

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Comment in

• Transcriptional control. Sinful repression.
  Wolffe AP. Wolffe AP. Nature. 1997 May 1;387(6628):16-7. doi: 10.1038/387016a0. Nature. 1997. PMID: 9139815 No abstract available.

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