Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization - PubMed (original) (raw)

Contribution of virion ICAM-1 to human immunodeficiency virus infectivity and sensitivity to neutralization

C D Rizzuto et al. J Virol. 1997 Jun.

Abstract

Incorporation of the intercellular adhesion molecule ICAM-1 into human immunodeficiency virus type 1 (HIV-1) particles increased virus infectivity on peripheral blood mononuclear cells (PBMCs) by two- to sevenfold. The degree of ICAM-1-mediated enhancement was greater for viruses bearing envelope glycoproteins derived from primary HIV-1 isolates than for those bearing envelope glycoproteins from laboratory-adapted strains. Treatment of target PBMCs with an antibody against LFA-1, a principal ICAM-1 receptor, was able to nullify the ICAM-1-mediated enhancement. The incorporation of ICAM-1 rendered HIV-1 virions less susceptible to neutralization by a monoclonal antibody directed against the viral envelope glycoproteins. Surprisingly, an antibody against ICAM-1 completely neutralized infection by ICAM-1-containing viruses, reducing the efficiency of virus entry by almost 100-fold. Thus, HIV-1 neutralization by an ICAM-1-directed antibody involves more than an inhibition of the contribution of ICAM-1 to virus entry.

PubMed Disclaimer

Similar articles

• T cells expressing activated LFA-1 are more susceptible to infection with human immunodeficiency virus type 1 particles bearing host-encoded ICAM-1.
  Fortin JF, Cantin R, Tremblay MJ. Fortin JF, et al. J Virol. 1998 Mar;72(3):2105-12. doi: 10.1128/JVI.72.3.2105-2112.1998. J Virol. 1998. PMID: 9499066 Free PMC article.
• Level of ICAM-1 surface expression on virus producer cells influences both the amount of virion-bound host ICAM-1 and human immunodeficiency virus type 1 infectivity.
  Paquette JS, Fortin JF, Blanchard L, Tremblay MJ. Paquette JS, et al. J Virol. 1998 Nov;72(11):9329-36. doi: 10.1128/JVI.72.11.9329-9336.1998. J Virol. 1998. PMID: 9765484 Free PMC article.
• Role of cellular adhesion molecules in HIV type 1 infection and their impact on virus neutralization.
  Hioe CE, Bastiani L, Hildreth JE, Zolla-Pazner S. Hioe CE, et al. AIDS Res Hum Retroviruses. 1998 Oct;14 Suppl 3:S247-54. AIDS Res Hum Retroviruses. 1998. PMID: 9814951 Review.
• A model for neutralization of viruses based on antibody coating of the virion surface.
  Burton DR, Saphire EO, Parren PW. Burton DR, et al. Curr Top Microbiol Immunol. 2001;260:109-43. doi: 10.1007/978-3-662-05783-4_7. Curr Top Microbiol Immunol. 2001. PMID: 11443871 Review. No abstract available.

Cited by

• Help or Hinder: Protein Host Factors That Impact HIV-1 Replication.
  Moezpoor MR, Stevenson M. Moezpoor MR, et al. Viruses. 2024 Aug 10;16(8):1281. doi: 10.3390/v16081281. Viruses. 2024. PMID: 39205255 Free PMC article. Review.
• Virion-incorporated CD14 enables HIV-1 to bind LPS and initiate TLR4 signaling in immune cells.
  Persaud AT, Khela J, Fernandes C, Chaphekar D, Burnie J, Tang VA, Colpitts CC, Guzzo C. Persaud AT, et al. J Virol. 2024 May 14;98(5):e0036324. doi: 10.1128/jvi.00363-24. Epub 2024 Apr 25. J Virol. 2024. PMID: 38661384 Free PMC article.
• Antiviral neutralizing antibodies: from in vitro to in vivo activity.
  Burton DR. Burton DR. Nat Rev Immunol. 2023 Nov;23(11):720-734. doi: 10.1038/s41577-023-00858-w. Epub 2023 Apr 17. Nat Rev Immunol. 2023. PMID: 37069260 Free PMC article. Review.
• Exposure to Secreted Bacterial Factors Promotes HIV-1 Replication in CD4+ T Cells.
  Znaidia M, de Souza-Angelo Y, Létoffé S, Staropoli I, Grzelak L, Ghigo JM, Schwartz O, Casartelli N. Znaidia M, et al. Microbiol Spectr. 2023 Apr 13;11(2):e0431322. doi: 10.1128/spectrum.04313-22. Epub 2023 Feb 28. Microbiol Spectr. 2023. PMID: 36853052 Free PMC article.
• P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.
  Burnie J, Persaud AT, Thaya L, Liu Q, Miao H, Grabinsky S, Norouzi V, Lusso P, Tang VA, Guzzo C. Burnie J, et al. Retrovirology. 2022 May 21;19(1):9. doi: 10.1186/s12977-022-00593-5. Retrovirology. 2022. PMID: 35597982 Free PMC article.

References

1. 1. Immunol Lett. 1991 Oct;30(2):219-27 - PubMed
2. 1. J Virol. 1992 Jan;66(1):235-43 - PubMed
3. 1. Science. 1992 Dec 18;258(5090):1935-8 - PubMed
4. 1. J Virol. 1993 May;67(5):2747-55 - PubMed
5. 1. AIDS Res Hum Retroviruses. 1993 Aug;9(8):733-40 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations

• Miscellaneous

  • NCI CPTAC Assay Portal