mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila - PubMed (original) (raw)
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
A Hilfiker et al. EMBO J. 1997.
Abstract
Dosage compensation is a regulatory process that insures that males and females have equal amounts of X-chromosome gene products. In Drosophila, this is achieved by a 2-fold enhancement of X-linked gene transcription in males, relative to females. The enhancement of transcription is mediated by the activity of a group of regulatory genes characterized by the male-specific lethality of their loss-of-function alleles. The products of these genes form a complex that is preferentially associated with numerous sites on the X chromosome in somatic cells of males but not of females. Binding of the dosage compensation complex is correlated with a significant increase in the presence of a specific histone isoform, histone 4 acetylated at Lys16, on this chromosome. Experimental results and sequence analysis suggest that an additional gene, males-absent on the first (mof), encodes a putative acetyl transferase that plays a direct role in the specific histone acetylation associated with dosage compensation. The predicted amino acid sequence of MOF exhibits a significant level of similarity to several other proteins, including the human HIV-1 Tat interactive protein Tip60, the human monocytic leukemia zinc finger protein MOZ and the yeast silencing proteins SAS3 and SAS2.
Similar articles
- Targeting of MOF, a putative histone acetyl transferase, to the X chromosome of Drosophila melanogaster.
Gu W, Szauter P, Lucchesi JC. Gu W, et al. Dev Genet. 1998;22(1):56-64. doi: 10.1002/(SICI)1520-6408(1998)22:1<56::AID-DVG6>3.0.CO;2-6. Dev Genet. 1998. PMID: 9499580 - Sex-biased transcription enhancement by a 5' tethered Gal4-MOF histone acetyltransferase fusion protein in Drosophila.
Schiemann AH, Li F, Weake VM, Belikoff EJ, Klemmer KC, Moore SA, Scott MJ. Schiemann AH, et al. BMC Mol Biol. 2010 Nov 9;11:80. doi: 10.1186/1471-2199-11-80. BMC Mol Biol. 2010. PMID: 21062452 Free PMC article. - ESA1 is a histone acetyltransferase that is essential for growth in yeast.
Smith ER, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J, Cook RG, Lucchesi JC, Allis CD. Smith ER, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3561-5. doi: 10.1073/pnas.95.7.3561. Proc Natl Acad Sci U S A. 1998. PMID: 9520405 Free PMC article. - Chromatin mechanisms in Drosophila dosage compensation.
Taipale M, Akhtar A. Taipale M, et al. Prog Mol Subcell Biol. 2005;38:123-49. doi: 10.1007/3-540-27310-7_5. Prog Mol Subcell Biol. 2005. PMID: 15881893 Review. - Dosage Compensation in Drosophila: Its Canonical and Non-Canonical Mechanisms.
Shevelyov YY, Ulianov SV, Gelfand MS, Belyakin SN, Razin SV. Shevelyov YY, et al. Int J Mol Sci. 2022 Sep 19;23(18):10976. doi: 10.3390/ijms231810976. Int J Mol Sci. 2022. PMID: 36142884 Free PMC article. Review.
Cited by
- Epigenetic inheritance and gene expression regulation in early Drosophila embryos.
Ciabrelli F, Atinbayeva N, Pane A, Iovino N. Ciabrelli F, et al. EMBO Rep. 2024 Oct;25(10):4131-4152. doi: 10.1038/s44319-024-00245-z. Epub 2024 Sep 16. EMBO Rep. 2024. PMID: 39285248 Free PMC article. Review. - Prevalent Fast Evolution of Genes Involved in Heterochromatin Functions.
Lin L, Huang Y, McIntyre J, Chang CH, Colmenares S, Lee YCG. Lin L, et al. Mol Biol Evol. 2024 Sep 4;41(9):msae181. doi: 10.1093/molbev/msae181. Mol Biol Evol. 2024. PMID: 39189646 Free PMC article. - Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress.
Taylor BC, Steinthal LH, Dias M, Yalamanchili HK, Ochsner SA, Zapata GE, Mehta NR, McKenna NJ, Young NL, Nuotio-Antar AM. Taylor BC, et al. Epigenetics Chromatin. 2024 Apr 27;17(1):12. doi: 10.1186/s13072-024-00536-8. Epigenetics Chromatin. 2024. PMID: 38678237 Free PMC article. - Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress.
Taylor BC, Steinthal LH, Dias M, Yalamanchili HK, Ochsner SA, Zapata GE, Mehta NR, McKenna NJ, Young NL, Nuotio-Antar AM. Taylor BC, et al. bioRxiv [Preprint]. 2024 Jan 22:2023.07.30.551059. doi: 10.1101/2023.07.30.551059. bioRxiv. 2024. PMID: 38328142 Free PMC article. Updated. Preprint. - Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation.
Xuan H, Xu L, Li K, Xuan F, Xu T, Wen H, Shi X. Xuan H, et al. J Mol Biol. 2024 Apr 1;436(7):168413. doi: 10.1016/j.jmb.2023.168413. Epub 2023 Dec 20. J Mol Biol. 2024. PMID: 38135180
References
- Genetics. 1975 Sep;81(1):135-41 - PubMed
- Genes Cells. 1996 Mar;1(3):325-36 - PubMed
- Science. 1982 Oct 22;218(4570):348-53 - PubMed
- J Mol Biol. 1990 Oct 5;215(3):403-10 - PubMed
- Proteins. 1991;9(3):180-90 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous