Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness - PubMed (original) (raw)
Comparative Study
Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness
E Hamelmann et al. Am J Respir Cell Mol Biol. 1997 Jun.
Abstract
The mechanisms underlying the development of airway hyperresponsiveness are not fully delineated. We addressed this question by studying the effects of passive sensitization with anti-OVA IgE on the development of altered airway responsiveness (AR) following local challenge with OVA in normal and athymic mice. Both normal and athymic BALB/c mice developed allergen-specific immediate cutaneous hypersensitivity after passive sensitization with anti-OVA IgE. In contrast, the combination of local challenge with allergen via the airways and passive sensitization triggered the development of airway hyperresponsiveness only in normal but not in athymic mice. Treatment of athymic mice with IL-5 significantly increased eosinophil accumulation in the lungs after local challenge with OVA; increased airway reactivity was only observed in athymic mice which received anti-OVA IgE, not an unrelated IgE, plus IL-5 treatment and airway challenge with OVA. These findings identify the requirement for allergen-specific IgE and IL-5 for the development of airway hyperresponsiveness following allergen challenge via the airways.
Similar articles
- Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Hamelmann E, et al. Am J Respir Cell Mol Biol. 2000 Sep;23(3):327-34. doi: 10.1165/ajrcmb.23.3.3796. Am J Respir Cell Mol Biol. 2000. PMID: 10970823 - Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.
Hamelmann E, Oshiba A, Loader J, Larsen GL, Gleich G, Lee J, Gelfand EW. Hamelmann E, et al. Am J Respir Crit Care Med. 1997 Mar;155(3):819-25. doi: 10.1164/ajrccm.155.3.9117011. Am J Respir Crit Care Med. 1997. PMID: 9117011 - Transfer of immediate hypersensitivity and airway hyperresponsiveness by IgE-positive B cells.
Lack G, Oshiba A, Bradley KL, Loader JE, Amran D, Larsen GL, Gelfand EW. Lack G, et al. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1765-73. doi: 10.1164/ajrccm.152.6.8520735. Am J Respir Crit Care Med. 1995. PMID: 8520735 - Role of IgE in the development of allergic airway inflammation and airway hyperresponsiveness--a murine model.
Hamelmann E, Tadeda K, Oshiba A, Gelfand EW. Hamelmann E, et al. Allergy. 1999 Apr;54(4):297-305. doi: 10.1034/j.1398-9995.1999.00085.x. Allergy. 1999. PMID: 10371087 Review. - Inhibition of the effector phase of IgE-mediated allergies by tolerogenic conjugates of allergens and monomethoxypolyethylene glycol.
Bitoh S, Wakefield R, Lang GM, Sehon AH. Bitoh S, et al. Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):316-8. doi: 10.1159/000237012. Int Arch Allergy Immunol. 1995. PMID: 7613157 Review.
Cited by
- IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis.
Wang Q, Lepus CM, Raghu H, Reber LL, Tsai MM, Wong HH, von Kaeppler E, Lingampalli N, Bloom MS, Hu N, Elliott EE, Oliviero F, Punzi L, Giori NJ, Goodman SB, Chu CR, Sokolove J, Fukuoka Y, Schwartz LB, Galli SJ, Robinson WH. Wang Q, et al. Elife. 2019 May 14;8:e39905. doi: 10.7554/eLife.39905. Elife. 2019. PMID: 31084709 Free PMC article. - House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα.
McKnight CG, Jude JA, Zhu Z, Panettieri RA Jr, Finkelman FD. McKnight CG, et al. Am J Respir Cell Mol Biol. 2017 Dec;57(6):674-682. doi: 10.1165/rcmb.2016-0356OC. Am J Respir Cell Mol Biol. 2017. PMID: 28700253 Free PMC article. - Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge.
Takeda K, Shiraishi Y, Ashino S, Han J, Jia Y, Wang M, Lee NA, Lee JJ, Gelfand EW. Takeda K, et al. J Allergy Clin Immunol. 2015 Feb;135(2):451-60. doi: 10.1016/j.jaci.2014.08.014. Epub 2014 Oct 11. J Allergy Clin Immunol. 2015. PMID: 25312762 Free PMC article. - IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M. Lajoie S, et al. Clin Exp Allergy. 2014 Jul;44(7):976-85. doi: 10.1111/cea.12341. Clin Exp Allergy. 2014. PMID: 24807637 Free PMC article. - In utero exposure to environmental tobacco smoke potentiates adult responses to allergen in BALB/c mice.
Penn AL, Rouse RL, Horohov DW, Kearney MT, Paulsen DB, Lomax L. Penn AL, et al. Environ Health Perspect. 2007 Apr;115(4):548-55. doi: 10.1289/ehp.9780. Epub 2007 Jan 4. Environ Health Perspect. 2007. PMID: 17450223 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials