A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function - PubMed (original) (raw)
. 1997 Nov 13;390(6656):175-9.
doi: 10.1038/36593.
Affiliations
- PMID: 9367155
- DOI: 10.1038/36593
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
D M Anderson et al. Nature. 1997.
Abstract
Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of the tumour necrosis factor receptor (TNFR) superfamily are integral to the regulation of the immune response. These structurally related proteins modulate cellular functions ranging from proliferation and differentiation to inflammation and cell survival or deaths. The functional activity of dendritic cells is greatly increased by signalling through the TNFR family member CD40. Here we report the characterization of RANK (for receptor activator of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the isolation of a RANK ligand (RANKL) by direct expression screening. RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, and increases the survival of RANK+ T cells generated with interleukin-4 and transforming growth factor (TGF)-beta. Thus RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.
Similar articles
- Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines.
Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H. Nakashima T, et al. Biochem Biophys Res Commun. 2000 Sep 7;275(3):768-75. doi: 10.1006/bbrc.2000.3379. Biochem Biophys Res Commun. 2000. PMID: 10973797 - Synovial dendritic cells in juvenile idiopathic arthritis (JIA) express receptor activator of NF-kappaB (RANK).
Varsani H, Patel A, van Kooyk Y, Woo P, Wedderburn LR. Varsani H, et al. Rheumatology (Oxford). 2003 Apr;42(4):583-90. Rheumatology (Oxford). 2003. PMID: 12649407 - TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells.
Josien R, Wong BR, Li HL, Steinman RM, Choi Y. Josien R, et al. J Immunol. 1999 Mar 1;162(5):2562-8. J Immunol. 1999. PMID: 10072496 - A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function.
Takahashi N, Udagawa N, Suda T. Takahashi N, et al. Biochem Biophys Res Commun. 1999 Mar 24;256(3):449-55. doi: 10.1006/bbrc.1999.0252. Biochem Biophys Res Commun. 1999. PMID: 10080918 Review. - Crystal structure of RANK ligand involved in bone metabolism.
Ito S, Hata T. Ito S, et al. Vitam Horm. 2004;67:19-33. doi: 10.1016/S0083-6729(04)67002-6. Vitam Horm. 2004. PMID: 15110169 Review.
Cited by
- RANK-RANKL-OPG Axis in MASLD: Current Evidence Linking Bone and Liver Diseases and Future Perspectives.
Monti F, Perazza F, Leoni L, Stefanini B, Ferri S, Tovoli F, Zavatta G, Piscaglia F, Petroni ML, Ravaioli F. Monti F, et al. Int J Mol Sci. 2024 Aug 24;25(17):9193. doi: 10.3390/ijms25179193. Int J Mol Sci. 2024. PMID: 39273141 Free PMC article. Review. - Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy.
Liao M, Zhu X, Lu Y, Yi X, Hu Y, Zhao Y, Ye Z, Guo X, Liang M, Jin X, Zhang H, Wang X, Zhao Z, Chen Y, Yan H. Liao M, et al. Nat Commun. 2024 Aug 25;15(1):7324. doi: 10.1038/s41467-024-51624-y. Nat Commun. 2024. PMID: 39183203 Free PMC article. - Crosstalk between bone and the immune system.
Okamoto K. Okamoto K. J Bone Miner Metab. 2024 Jul;42(4):470-480. doi: 10.1007/s00774-024-01539-x. Epub 2024 Jul 26. J Bone Miner Metab. 2024. PMID: 39060500 Free PMC article. Review. - Osteoprotegerin mediates adipogenesis in obesity.
Lyu Z, Chan YT, Lu Y, Fung Lam T, Wu X, Wu J, Xu L, Yang W, Zhang C, Lidan Zhong L, Wang N. Lyu Z, et al. J Adv Res. 2024 Aug;62:245-255. doi: 10.1016/j.jare.2024.06.018. Epub 2024 Jun 19. J Adv Res. 2024. PMID: 38906326 Free PMC article. - Unraveling the Intricacies of OPG/RANKL/RANK Biology and Its Implications in Neurological Disorders-A Comprehensive Literature Review.
Freeman C, A S MD, A S P. Freeman C, et al. Mol Neurobiol. 2024 May 22. doi: 10.1007/s12035-024-04227-z. Online ahead of print. Mol Neurobiol. 2024. PMID: 38777981 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials