Host-pathogen interactions during entry and actin-based movement of Listeria monocytogenes - PubMed (original) (raw)
Review
Host-pathogen interactions during entry and actin-based movement of Listeria monocytogenes
K Ireton et al. Annu Rev Genet. 1997.
Abstract
Listeria monocytogenes is a pathogenic bacterium that induces its own uptake into mammalian cells, and spreads from one cell to another by an actin-based motility process. Entry into host cells involves the bacterial surface proteins InlA (internalin) and InlB. The receptor for InlA is the cell adhesion molecule E-cadherin. InlB-mediated entry requires activation of the host protein phosphoinositide (PI) 3-kinase, probably in response to engagement of a receptor. Actin-based movement of L. monocytogenes is mediated by the bacterial surface protein ActA. The N-terminal region of this protein is necessary and sufficient for polymerization of host cell actin. Other host proteins involved in bacterial motility include profilin, Vasodilator-Stimulated Phosphoprotein (VASP), the Arp2/Arp3 complex, and cofilin. Studies of entry and intracellular movement of L. monocytogenes could lead to a better understanding of receptor-ligand signaling and dynamics of actin polymerization in mammalian cells.
Similar articles
- Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling.
Cossart P, Lecuit M. Cossart P, et al. EMBO J. 1998 Jul 15;17(14):3797-806. doi: 10.1093/emboj/17.14.3797. EMBO J. 1998. PMID: 9669997 Free PMC article. Review. - Entry of the bacterial pathogen Listeria monocytogenes into mammalian cells.
Ireton K. Ireton K. Cell Microbiol. 2007 Jun;9(6):1365-75. doi: 10.1111/j.1462-5822.2007.00933.x. Epub 2007 Apr 5. Cell Microbiol. 2007. PMID: 17419717 Review. - Non-classical use of clathrin during bacterial infections.
Cossart P, Veiga E. Cossart P, et al. J Microsc. 2008 Sep;231(3):524-8. doi: 10.1111/j.1365-2818.2008.02065.x. J Microsc. 2008. PMID: 18755008 Review. - Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.
Welch MD, Iwamatsu A, Mitchison TJ. Welch MD, et al. Nature. 1997 Jan 16;385(6613):265-9. doi: 10.1038/385265a0. Nature. 1997. PMID: 9000076 - Reconstitution of actin-based motility of Listeria and Shigella using pure proteins.
Loisel TP, Boujemaa R, Pantaloni D, Carlier MF. Loisel TP, et al. Nature. 1999 Oct 7;401(6753):613-6. doi: 10.1038/44183. Nature. 1999. PMID: 10524632
Cited by
- Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility.
Skoble J, Portnoy DA, Welch MD. Skoble J, et al. J Cell Biol. 2000 Aug 7;150(3):527-38. doi: 10.1083/jcb.150.3.527. J Cell Biol. 2000. PMID: 10931865 Free PMC article. - Mutants of Listeria monocytogenes defective in In vitro invasion and cell-to-cell spreading still invade and proliferate in hepatocytes of neutropenic mice.
Appelberg R, Leal IS. Appelberg R, et al. Infect Immun. 2000 Feb;68(2):912-4. doi: 10.1128/IAI.68.2.912-914.2000. Infect Immun. 2000. PMID: 10639462 Free PMC article. - A novel C-terminal mutation resulting in constitutive activation of the Listeria monocytogenes central virulence regulatory factor PrfA.
Xayarath B, Smart JI, Mueller KJ, Freitag NE. Xayarath B, et al. Microbiology (Reading). 2011 Nov;157(Pt 11):3138-3149. doi: 10.1099/mic.0.049957-0. Epub 2011 Aug 11. Microbiology (Reading). 2011. PMID: 21835879 Free PMC article. - A comparative analysis of mitochondrial ORFans: new clues on their origin and role in species with doubly uniparental inheritance of mitochondria.
Milani L, Ghiselli F, Guerra D, Breton S, Passamonti M. Milani L, et al. Genome Biol Evol. 2013;5(7):1408-34. doi: 10.1093/gbe/evt101. Genome Biol Evol. 2013. PMID: 23824218 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous