An essential role for ectodomain shedding in mammalian development - PubMed (original) (raw)

. 1998 Nov 13;282(5392):1281-4.

doi: 10.1126/science.282.5392.1281.

J L Slack, P Reddy, K L Stocking, S W Sunnarborg, D C Lee, W E Russell, B J Castner, R S Johnson, J N Fitzner, R W Boyce, N Nelson, C J Kozlosky, M F Wolfson, C T Rauch, D P Cerretti, R J Paxton, C J March, R A Black

Affiliations

An essential role for ectodomain shedding in mammalian development

J J Peschon et al. Science. 1998.

Abstract

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-alpha converting enzyme (TACE), has been identified only in the case when tumor necrosis factor-alpha (TNFalpha) is released. Analyses of cells lacking this metalloproteinase-disintegrin revealed an expanded role for TACE in the processing of other cell surface proteins, including a TNF receptor, the L-selectin adhesion molecule, and transforming growth factor-alpha (TGFalpha). The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.

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