[Anti-CD4 therapy in treatment of rheumatoid arthritis--have the die been cast?] - PubMed (original) (raw)
Review
doi: 10.1007/s003930050119.
[Article in German]
Affiliations
- PMID: 9864838
- DOI: 10.1007/s003930050119
Review
[Anti-CD4 therapy in treatment of rheumatoid arthritis--have the die been cast?]
[Article in German]
G Keysser et al. Z Rheumatol. 1998 Oct.
Abstract
The hypothesis of rheumatoid arthritis (RA) as a T cell mediated disease has led to the development of numerous therapeutic approaches that target the function of T cells. The development of monoclonal antibodies against the T cell surface molecule CD4 has raised hopes to achieve a major progress in the treatment of RA. However, after encouraging results in early open studies, double blind trials were unable to demonstrate the efficacy of anti-CD4-therapy in RA. There are numerous reasons to explain the failure of this treatment approach. Besides the fact that the T cell hypothesis of RA has repeatedly been challenged, pharmacological problems or an inappropriate selection of outcome criteria have to be considered. The final evaluation of anti-CD4 therapy in RA will be possible only after the testing of newly developed non-depleting anti-CD4 antibodies.
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