Shadid Hossain | University of Rajshahi, Bangladesh (original) (raw)

Papers by Shadid Hossain

International Journal of Biomedicine, 2016

Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera c... more Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrica (BC) are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of the crude extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice. Methods: Antidiarrheal activities of extracts were evaluated at three doses (100 mg/kg, 200 mg/kg and 400 mg/kg) and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400 mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively. This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400 mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400 mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively. The aqueous extracts of AN, CL and BC were able to increase the percentage inhibition of the charcoal meal movement. Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.

Journal of Ethnopharmacology, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

International Journal of Advanced Multidisciplinary Research, 2016

The prime objective of present study is to evaluate in vitro antibacterial activity, cytotoxic ac... more The prime objective of present study is to evaluate in vitro antibacterial activity, cytotoxic activity and in vivo antidiarrheal activity of ethanolic extract of Aphanamixis polystachya (wall.) parker leaf. The crude leaf extract was found to show strong lethality against the brine shrimp nauplii in a dose dependent manner having LC50 value at a concentration of 40µg/ml. Antimicrobial activity of this extract was performed against both gram positive and gram negative bacteria using kanamycin as standard and the result showed moderate to good activity against Sarcina lutea, Staphylococcous aureus, Pseudomonas, Hafnia, Shigella boydii, Shigella sonnie, Escherichia coli , Shigella dysenteriae, and Salmonella typhi. Castor oil inducing antidiarrheal activity of ethanolic extract of Aphanamixis polystachya (wall.) parker leaf in Swiss Albino mice was evaluated using Loperamide as standard chemical but the extract didn't show remarkable antidiarrheal activity.

Modern Journal of Health and Applied Sciences, 2024

Aphanamixis polystachya (Wall.) Parker is a sanative herb with colossal corny convenience. This p... more Aphanamixis polystachya (Wall.) Parker is a sanative herb with colossal corny convenience. This plant contains a wide range of secondary metabolites, which have been linked to numerous medicinal uses. The current investigation aimed to find the phytochemical components and assess the hypoglycemic impact of n-hexane, chloroform, and methanol extracts of Aphanamixis polystachya seeds. Phytochemical screening was carried out using qualitative analysis. To measure hypoglycemic activity, hyperglycemic lab rats with glucose and STZ were used. All of the extractives contained the phytochemicals flavonoids, terpenoids, and steroids. After 30 minutes of administration, the n-hexane extract showed a drop of 41.44% in blood glucose levels, while the chloroform extract exhibited the most significant reduction, 47.76%, at a dose of 150 mg/g BW. The fascinating discovery is that the methanolic extract, which contained carbohydrates absent in the other extracts, resulted in a 14.92% increase in blood glucose levels within 30 minutes of treatment. Organic seed extracts can prevent hyperglycemia, which will be a significant argument in favor of the Aphanamixis polystachya plant's common uses in traditional medicine to treat diabetes. More research is required to determine the exact mechanism of action, pinpoint the active ingredients, and clarify their structures.

International Journal of Biomedicine, 2016

Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera c... more Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrica (BC) are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of the crude extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice. Methods: Antidiarrheal activities of extracts were evaluated at three doses (100 mg/kg, 200 mg/kg and 400 mg/kg) and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400 mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively. This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400 mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400 mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively. The aqueous extracts of AN, CL and BC were able to increase the percentage inhibition of the charcoal meal movement. Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.

Journal of Ethnopharmacology, 2020

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

International Journal of Advanced Multidisciplinary Research, 2016

The prime objective of present study is to evaluate in vitro antibacterial activity, cytotoxic ac... more The prime objective of present study is to evaluate in vitro antibacterial activity, cytotoxic activity and in vivo antidiarrheal activity of ethanolic extract of Aphanamixis polystachya (wall.) parker leaf. The crude leaf extract was found to show strong lethality against the brine shrimp nauplii in a dose dependent manner having LC50 value at a concentration of 40µg/ml. Antimicrobial activity of this extract was performed against both gram positive and gram negative bacteria using kanamycin as standard and the result showed moderate to good activity against Sarcina lutea, Staphylococcous aureus, Pseudomonas, Hafnia, Shigella boydii, Shigella sonnie, Escherichia coli , Shigella dysenteriae, and Salmonella typhi. Castor oil inducing antidiarrheal activity of ethanolic extract of Aphanamixis polystachya (wall.) parker leaf in Swiss Albino mice was evaluated using Loperamide as standard chemical but the extract didn't show remarkable antidiarrheal activity.

Modern Journal of Health and Applied Sciences, 2024

Aphanamixis polystachya (Wall.) Parker is a sanative herb with colossal corny convenience. This p... more Aphanamixis polystachya (Wall.) Parker is a sanative herb with colossal corny convenience. This plant contains a wide range of secondary metabolites, which have been linked to numerous medicinal uses. The current investigation aimed to find the phytochemical components and assess the hypoglycemic impact of n-hexane, chloroform, and methanol extracts of Aphanamixis polystachya seeds. Phytochemical screening was carried out using qualitative analysis. To measure hypoglycemic activity, hyperglycemic lab rats with glucose and STZ were used. All of the extractives contained the phytochemicals flavonoids, terpenoids, and steroids. After 30 minutes of administration, the n-hexane extract showed a drop of 41.44% in blood glucose levels, while the chloroform extract exhibited the most significant reduction, 47.76%, at a dose of 150 mg/g BW. The fascinating discovery is that the methanolic extract, which contained carbohydrates absent in the other extracts, resulted in a 14.92% increase in blood glucose levels within 30 minutes of treatment. Organic seed extracts can prevent hyperglycemia, which will be a significant argument in favor of the Aphanamixis polystachya plant's common uses in traditional medicine to treat diabetes. More research is required to determine the exact mechanism of action, pinpoint the active ingredients, and clarify their structures.