Esra Hatipoglu | Sağlık Bilimleri Üniversitesi (original) (raw)
Papers by Esra Hatipoglu
PurposeIn sporadic pituitary adenomas the role of Ubiquitin-specific protease 8 (USP8) is not cle... more PurposeIn sporadic pituitary adenomas the role of Ubiquitin-specific protease 8 (USP8) is not clearly defined. Although mutations in USP8 gene are known to cause corticotroph adenomas, whether changes in expression of USP8 in other pituitary adenomas have not been clarified, yet. In this study we addressed the changes in USP8 gene expression levels in pituitary adenomas relative to non-adenomatous brain tissue.MethodsUSP8 gene expression analysis was performed on a total of 43 tissue samples from human pituitary adenomas and on 16 tissue samples from non-pituitary brain tissues (control group). Adenomatous tissues and control tissues were assessed for quantification of RNA expression of USP8.The levels of USP8 gene expression were determined relative to those in control group.ResultsUSP8 gene expression levels in pituitary adenomas (PA) were 3.7 times higher than the levels in control brain tissues (CBT) (p = 0.002). Levels of USP8 expression in secertory PA’s were significantly hig...
Cumhuriyet Medical Journal, 2019
In this study we aimed to determine whether thyroid USG is useful in the absence of any complaint... more In this study we aimed to determine whether thyroid USG is useful in the absence of any complaints and prominent self/family history or risk of thyroid pathology. Method: Thyroid USG results of 1198 asymptomatic adults, who had no self or family history of any thyroid pathology, were retrospectively included. In all cases USG was done by the same radiologist. Thyroid nodules were classified based on their sonographic characteristics suspicious for malignancy according to American Thyroid Association (ATA)-2015 guideline. Results: Based on ATA-2015 criteria 5% (n=61) detected nodule with high risk and 27% (n=325) detected nodule with intermediate risk for malignancy. Three percent (n=33) had nodules with low risk for malignancy based on USG findings. Conclusions: USG alone may not be a decisive screening tool for thyroid carcinoma. Personal/family history and risks may guide in which cases thyroid USG would be more reliable.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbi... more Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD). In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4. Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls. Fifty-three patients and 30 healthy controls were included in the study. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study. Biochemistry values and hemograms were recorded for all patients and for control group. NLR was calculated. The relationship between MPV/NLR and protein, fibrinogen, and proteinuria was evaluated. Our study showed a statistically significant difference between CKD group and healthy control (HC) group in uric acid, fibrinogen, C-reactive protein, and NLR values (P <0.01, P &...
Endocrine Abstracts, 2016
Journal of Istanbul Faculty of Medicine, 2009
Granulocytic sarcoma is a rare extramedullary tumor that originates from the primitive granulocyt... more Granulocytic sarcoma is a rare extramedullary tumor that originates from the primitive granulocytic cells. Granulocytic sarcoma develops during the courses of acute myleoid leukemia, myelodisplastic syndrome and myeloproliferative diseases and frequently it is observed on the bones, soft tissue, periost, lymph nodes and skin. Here we report a 60 year old female patient who is at first diagnosed as diffuse large B cell lymphoma according to the biopsy result of the 6x10 cm nodular lesion on the anterolateral side of her left calf and at last diagnosed as granulocytic sarcoma upon reevaluation of the biopsy material. Granulocytic sarcomas are frequently confused with lymphomas or the sarcomas. Here the difficulties of the diagnosis of granulocytic sarcoma is discussed and reviewed in association with the literature.
Experimental and Clinical Endocrinology & Diabetes, 2015
ABSTRACT Objective: To evaluate the association between cognitive functions and metabolic status ... more ABSTRACT Objective: To evaluate the association between cognitive functions and metabolic status in cases with gestational diabetes mellitus (GDM). Methods: In this study 44 patients with GDM and 45 normal pregnant were included. Depression was evaluated with Beck's depression inventory (BDI). Cognitive functions were evaluated with Montreal cognitive assessment (MOCA), paced auditory serial addition test (PASAT), spatial recall test (SRT), symbol digit modalities (SDMT), and word list generation (WLG). Results: The mean gestational age, educational level and account of previous birth of the subjects in the study were not statistically different between the groups. The mean scores of BDI of the 2 groups were not statistically different. MOCA score and SDMT was significantly decreased in GDM in comparison to NP (p=0.005, p=0.04 respectively). Also, SDMT score was inversely correlated with number of pregnancies, postprandial blood glucose and HbA1c.The scores of PASAT, SRT, SPART and WLG were statistically similar between the groups. Conclusions: Our findings may be a clue for early onset of impairment in cognitive functions in cases with new onset diabetes during pregnancy. © Georg Thieme Verlag KG Stuttgart · New York.
Neuro endocrinology letters, 2013
In acromegaly, the gastrointestinal system is under the influence of excessive growth hormone (GH... more In acromegaly, the gastrointestinal system is under the influence of excessive growth hormone (GH) and insulin like growth factor-1 (IGF-I). Increased bowel length and delayed transit time may cause functional disturbance of the bowel. The objective of the current study is to evaluate the frequency of irritable bowel syndrome (IBS) in cases with acromegaly. Twenty-three active cases with acromegaly newly diagnosed between 2010-2011 were included in the study. The control group consisted of ninety gender and age-matched healthy controls (HC). All cases were questioned for presence of IBS using Rome III criteria. Abdominal ultrasonography and colonoscopy results of acromegalic patients were obtained. In addition, cases with acromegaly were evaluated for their quality of life and status of depression by using the Acromegaly Quality of Life Questionnaire (AcroQoL) and Beck Depression Inventory (BDI), respectively. The median GH and IGF-1 levels of cases with acromegaly were 5.72 [IQR: 2...
Turkiye Klinikleri Journal of Medical Sciences, 2014
Tip 2 Diabetes Mellitus'ta Kornea Endotel Morfolojisi, Yoğunluğu ve Merkezi Kornea Kalınlığı Ö ÖZ... more Tip 2 Diabetes Mellitus'ta Kornea Endotel Morfolojisi, Yoğunluğu ve Merkezi Kornea Kalınlığı Ö ÖZ ZE ET T A Am ma aç ç: :Kor ne a en do tel hüc re mor fo lo ji si, yo ğun lu ğu ve mer ke zi kor ne a ka lın lı ğı nın tip 2 di yabe ti olan has ta lar ile di ya be ti ol ma yan sağ lık lı gö nül lü ler le kar şı laş tı rıl ma sı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu pros pek tif kli nik ça lış ma da, tip 2 di a be tes mel li tus (DM)' lu 30 has ta nın 60 gö zü ile, di ya bet li ol ma yan 51 sağ lık lı gö nül lü nün 102 gö zü ça lış ma ya alın dı. Her bir di ya be tik ol gu için be den kit le in dek si he saplan dı, aç lık kan şeke ri (AKŞ) ve HbA1c dü zey le ri öl çül dü. Kon trol gru bu na, 2 kez ya pı lan AKŞ öl çü mü <100 mg/dL olan sağ lık lı bi rey ler dâhil edil di. En do tel hüc re yo ğun lu ğu (EHY), or ta la ma hüc re bo yutu (OHB), stan dart sap ma (SS), hüc re ala nı var yas yon kat sa yı sı (VK), hek za go na li te yüz de si (HEKY) ve mer ke zi kor ne a ka lın lı ğı (MKK), spe kü ler mik ros kop ile öl çül dü. B Bu ul l g gu u l la ar r: : Tip 2 DM'li grup ile sağ lıklı kon trol le rin yaş or ta la ma la rı (±stan dart sap ma) sı ra sıy la 54,8±9,6 yıl ve 53,3±8,2 yıl idi. Grup lar yaş ve cin si yet açı sın dan ben zer di (sı ra sıy la p=0,454 ve p=0,672). Tip 2 DM'li ol gu lar ile sağ lık lı kon trol ler ara sın da EHY, OHB, SS, VK, HEKY ve MKK açı sın dan is ta tis tik sel ola rak an lam lı bir fark bu lun ma dı (sı ra sıy la p=0,815, p=1,000, p=0,868, p=0,934, p=0,087, p=0,236). Di ya be tik ol gu lar da HbA1c ile MKK ara sın da po zi tif ko re las yon sap tan dı (r=0,297, p=0,026). On yıl dan uzun sü re di ya be ti olan lar da MKK, da ha kı sa sü re li DM'li ol gu la ra gö re da ha faz la ol ma eği li min de idi (sı ra sıy la 537,2±32,0 µm ve 519,0±28,2 µm). An cak bu fark is ta tis tik sel ola rak an lam lı de ğil di (p=0,066). S So o n nu uç ç: : Uzun sü re li ve kon trol süz di ya be ti olan has ta lar da kor ne a en do te lin de mey da na ge le bi le cek ya pı sal de ği şik lik ler, kor ne a kalın lı ğın da ar tı şa yol aça bi lir. Di ya be tik has ta lar DM komp li kas yon la rı açı sın dan iz le nir ken, kro nik hi perg li se mi nin kor ne a üze rin de ki et ki le ri de göz önün de bu lun du rul ma lı dır.
European Journal of Internal Medicine, 2009
Background: Nonalcoholic fatty liver disease (NAFLD) shares similar risk factors with coronary ar... more Background: Nonalcoholic fatty liver disease (NAFLD) shares similar risk factors with coronary artery (CAD). NAFLD is getting more common and present in up to one-third of the Turkish population while Turkish people change their traditional lifestyle nutrutinal behaviors. We aimed to determine if NAFLD has any role in the development of CAD. The other question was the need of screening or surveillance of NAFLD patients for CAD in Turkey. Method: We evaluated the risk factors for CAD and demografic characteristics of NAFLD patients. 34 patients diagnosed with NAFLD by ultrasonography and alcohol cosumption history were enrolled. Demographic and anthropometric parameters, oral glucose tolerance test with insulin levels, transaminase levels, C-reactive protein (CRP) and all components of metabolic syndrome criteria were measured in all patients. The patients were evaluated for CAD by a cardiologist according to guidelines. Results: Elevated transaminase level was found in 37% of NAFLD patients. This increase was significantly associated with body mass index, waist/hip ratio, fasting glucose, hyperinsulinemia, low high density lipoprotein (HDL), male sex, high CRP levels. CAD was found in 32.6% of patients with elevated transaminase and only 10.2% of patients with normal transaminase. Conclusion: These findings strongly suggest that NAFLD is likely to be associated with increased CAD risk. Screening and surveillance stratagies for CAD may be suggested to patients with NAFLD especially when they have elevated transaminases (steatohepatitis) in Turkey.
European Journal of Internal Medicine, 2009
1diabetes (n: 1). In 2 patients the diagnosis of auto-immune disease preceeded the diagnosis of A... more 1diabetes (n: 1). In 2 patients the diagnosis of auto-immune disease preceeded the diagnosis of AIH. In the other cases, the diagnosis of these diseases was concomitant with the hepatopathy. Discussion & conclusion: AIH is frequently associated at least with another autoimmune disease. The presence of disturbance of the hepatic test in the context of autoimmunity must make evoke the diagnosis of AIH. Conversely, they must be systematically looked out in the presence of AIH, in order to avoid the delay diagnosis and therapeutic P0059
European Journal of Internal Medicine, 2009
European Journal of Internal Medicine, 2009
sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alte... more sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alterations of bone density in the right iliac. Abdomino-pelvic ultra-sound showed iliac, lumbo aortic and retrocrural lymphadenopathies. Renal, pelvic, thyroid and breast ultrasound were normal. Laboratory revealed increased LDH (1 372 U/L) and anemia (Hb 11.8 g/dL). Further evaluation showed thrombocytopenia (18 000) and rising values of LDH that reached 4 404U/L. Protein electrophoresis, beta 2 microglobulin and anti-HIV 1 and 2 were negative. Myelogram revealed hypercellular bone marrow with invasion by atypical cells. A CT revealed multiple iliac, retroperitoneal and supraclavicular adenopathies; lytic lesion in the left scapula; lytic mass in the right iliac bone about 12x13 cm, destroying the iliac bone, sacrum and right sacroiliac joint and invading the right gluteus muscle. Histology of CT-guided biopsy of the lesion revealed a ALCL, with CD30, CD4, ALK and EMA positive markers. The final diagnosis was systemic anaplastic lymphoma, stage IV-B, with bone marrow and muscle skeletal involvement. She was medicated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP chemotherapy)and died of sepsis 2 weeks later. Discussion & conclusion: ALK-positive anaplastic large-cell lymphomas have a more favorable prognosis, but staging is also a very important prognostic factor. It is therefore extremely important an early diagnosis. Unfortunately,in this particular case, the patient had a late diagnosis and did succumb to overwhelming infection before the result of chemotherapy could be evaluated.
European Journal of Internal Medicine, 2009
sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alte... more sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alterations of bone density in the right iliac. Abdomino-pelvic ultra-sound showed iliac, lumbo aortic and retrocrural lymphadenopathies. Renal, pelvic, thyroid and breast ultrasound were normal. Laboratory revealed increased LDH (1 372 U/L) and anemia (Hb 11.8 g/dL). Further evaluation showed thrombocytopenia (18 000) and rising values of LDH that reached 4 404U/L. Protein electrophoresis, beta 2 microglobulin and anti-HIV 1 and 2 were negative. Myelogram revealed hypercellular bone marrow with invasion by atypical cells. A CT revealed multiple iliac, retroperitoneal and supraclavicular adenopathies; lytic lesion in the left scapula; lytic mass in the right iliac bone about 12x13 cm, destroying the iliac bone, sacrum and right sacroiliac joint and invading the right gluteus muscle. Histology of CT-guided biopsy of the lesion revealed a ALCL, with CD30, CD4, ALK and EMA positive markers. The final diagnosis was systemic anaplastic lymphoma, stage IV-B, with bone marrow and muscle skeletal involvement. She was medicated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP chemotherapy)and died of sepsis 2 weeks later. Discussion & conclusion: ALK-positive anaplastic large-cell lymphomas have a more favorable prognosis, but staging is also a very important prognostic factor. It is therefore extremely important an early diagnosis. Unfortunately,in this particular case, the patient had a late diagnosis and did succumb to overwhelming infection before the result of chemotherapy could be evaluated.
Endocrine Journal, 2013
Female sexual dysFunction (FSD) has many dimensions and may be affected by various factors such a... more Female sexual dysFunction (FSD) has many dimensions and may be affected by various factors such as age, education, chronic diseases, medications, psychological and physical conditions [1]. Dysfunction of the hypothalamic-pituitary axis, hyperprolactinemia, surgical or medical castration, premature ovarian failure, old age and chronic birth control use are common causes of hormonally based FSD [2]. FSD traditionally includes disorders of desire, arousal, pain/discomfort, inhibited orgasm, and satisfaction [3, 4]. Sexual prob
Growth Hormone & IGF Research
Kocatepe Tıp Dergisi
AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi... more AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi arasındaki ilişkiyi değerlendirmektir.GEREÇ VE YÖNTEM: Hashimoto tiroiditli 49 premenopozal kadın ve yaş ve vücut kitle indeksi (VKI) uyumlu 23 sağlıklı kadın, bu kesitsel karşılaştırmalı çalışmaya dahil edildi. Plazma nesfatin-1, açlık ve tokluk glukoz, hemoglobin A1c (HbA1c), açlık insülin, kolesterol parametreleri, serbest tiroksin (ST4), serbest T3 (ST3), tirotropin (TSH), anti-tiroid peroksidaz antikor (anti-TPO) and anti-tiroglobin (anti-TG) antikor değerleri için kan örnekleri alındı. Ek olarak tüm vakalarda, insülin direnci için homeostatik model değerlendirmesi (HOMA-İR) ve vücut kitle indeksi (VKİ) hesaplandı ve bel/kalça oranı ölçüldü.BULGULAR: Hashimoto tiroiditli hastaların ortalama yaşı 35,5±8,1, kontrol grubunun ise 33,2±7,1 idi (p=0.324). VKI ve bel/kalça oranı, gruplar arasında benzerdi (p=0.239 ve p=0.317). TSH, anti-TPO ve anti-TG düzeyleri hasta grubunda anlamlı dere...
Therapeutic advances in endocrinology and metabolism, 2018
It is necessary to stimulate serum thyroid-stimulating hormone (TSH) levels either endogenously b... more It is necessary to stimulate serum thyroid-stimulating hormone (TSH) levels either endogenously by thyroid hormone withdrawal (THW) or exogenously by administration of recombinant human TSH (rhTSH) for radioactive iodine (RAI) therapy. Thyrotropin alfa (Thyrogen) has many advantages over THW. Radiation dose to laboratory staff while drawing blood for tests on the day 5 is one of the disadvantages of preferring Thyrogen. Our aim was to compare day 3 and day 5 blood test results after Thyrogen injections. In our study, Thyrogen was preferred in 32 differentiated thyroid cancer patients with a mean age of 50.5 ± 12.3 years. Thyrogen was injected on day 1 and day 2 intramuscularly in all patients before I-131 was given on day 3. A total of 22 patients received 5 mCi RAI for ablation control scintigraphy and 10 patients received 100-250 mCi RAI for ablation or therapy (high-dose group). Blood tests were performed on day 3 and day 5 after Thyrogen injections. Mean TSH level was 98.1 mg/dl...
African health sciences, 2015
To investigate the relationship between maternal vitamin D status and glucose intolerance, and it... more To investigate the relationship between maternal vitamin D status and glucose intolerance, and its impact on pregnant women and their newborns. A cohort of pregnant women were divided into three groups: women with gestational diabetes mellitus, ones with normal results both after the 50 gr and 100 gr OGTT (CG-1) and ones having a positive result after the 50 gr OGTT screening but negative results for gestational diabetes mellitus (GDM) after the 100 gr OGTT (CG-2). The newborn length in CG-1 was greater than in GDM and CG-2 (p= 0.002 and p= 0.02). Fasting blood glucose and insulin resistance (IR) were negatively correlated with length of the newborns (r=-0.3, p=0.03 and r=-0.3, p=0.01). The newborns of women with GDM had lower APGAR-1 and 5 scores than those of CG-1 and CG-2 (APGAR-1 p= 0.001 and p= 0.004, APGAR-5 p=0.005 and p=0.007, respectively). APGAR scores were correlated negatively with IR (APGAR-1 r=-0.32, p=0.01, APGAR-5 r=-0.3, p=0.03) and positively with 25OHD levels (APG...
PurposeIn sporadic pituitary adenomas the role of Ubiquitin-specific protease 8 (USP8) is not cle... more PurposeIn sporadic pituitary adenomas the role of Ubiquitin-specific protease 8 (USP8) is not clearly defined. Although mutations in USP8 gene are known to cause corticotroph adenomas, whether changes in expression of USP8 in other pituitary adenomas have not been clarified, yet. In this study we addressed the changes in USP8 gene expression levels in pituitary adenomas relative to non-adenomatous brain tissue.MethodsUSP8 gene expression analysis was performed on a total of 43 tissue samples from human pituitary adenomas and on 16 tissue samples from non-pituitary brain tissues (control group). Adenomatous tissues and control tissues were assessed for quantification of RNA expression of USP8.The levels of USP8 gene expression were determined relative to those in control group.ResultsUSP8 gene expression levels in pituitary adenomas (PA) were 3.7 times higher than the levels in control brain tissues (CBT) (p = 0.002). Levels of USP8 expression in secertory PA’s were significantly hig...
Cumhuriyet Medical Journal, 2019
In this study we aimed to determine whether thyroid USG is useful in the absence of any complaint... more In this study we aimed to determine whether thyroid USG is useful in the absence of any complaints and prominent self/family history or risk of thyroid pathology. Method: Thyroid USG results of 1198 asymptomatic adults, who had no self or family history of any thyroid pathology, were retrospectively included. In all cases USG was done by the same radiologist. Thyroid nodules were classified based on their sonographic characteristics suspicious for malignancy according to American Thyroid Association (ATA)-2015 guideline. Results: Based on ATA-2015 criteria 5% (n=61) detected nodule with high risk and 27% (n=325) detected nodule with intermediate risk for malignancy. Three percent (n=33) had nodules with low risk for malignancy based on USG findings. Conclusions: USG alone may not be a decisive screening tool for thyroid carcinoma. Personal/family history and risks may guide in which cases thyroid USG would be more reliable.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbi... more Atherosclerosis, which develops as a result of inflammation, is the most important cause of morbidity and mortality in chronic kidney disease (CKD). In this study, we investigated the relationship of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with inflammation and proteinuria in patients with CKD Stage 3-4. Healthy individuals who applied to nephrology clinic for checkup purposes acted as controls. Fifty-three patients and 30 healthy controls were included in the study. Patients with diabetes mellitus, active infection, malignancy, and coronary artery disease were excluded from the study. Biochemistry values and hemograms were recorded for all patients and for control group. NLR was calculated. The relationship between MPV/NLR and protein, fibrinogen, and proteinuria was evaluated. Our study showed a statistically significant difference between CKD group and healthy control (HC) group in uric acid, fibrinogen, C-reactive protein, and NLR values (P <0.01, P &...
Endocrine Abstracts, 2016
Journal of Istanbul Faculty of Medicine, 2009
Granulocytic sarcoma is a rare extramedullary tumor that originates from the primitive granulocyt... more Granulocytic sarcoma is a rare extramedullary tumor that originates from the primitive granulocytic cells. Granulocytic sarcoma develops during the courses of acute myleoid leukemia, myelodisplastic syndrome and myeloproliferative diseases and frequently it is observed on the bones, soft tissue, periost, lymph nodes and skin. Here we report a 60 year old female patient who is at first diagnosed as diffuse large B cell lymphoma according to the biopsy result of the 6x10 cm nodular lesion on the anterolateral side of her left calf and at last diagnosed as granulocytic sarcoma upon reevaluation of the biopsy material. Granulocytic sarcomas are frequently confused with lymphomas or the sarcomas. Here the difficulties of the diagnosis of granulocytic sarcoma is discussed and reviewed in association with the literature.
Experimental and Clinical Endocrinology & Diabetes, 2015
ABSTRACT Objective: To evaluate the association between cognitive functions and metabolic status ... more ABSTRACT Objective: To evaluate the association between cognitive functions and metabolic status in cases with gestational diabetes mellitus (GDM). Methods: In this study 44 patients with GDM and 45 normal pregnant were included. Depression was evaluated with Beck's depression inventory (BDI). Cognitive functions were evaluated with Montreal cognitive assessment (MOCA), paced auditory serial addition test (PASAT), spatial recall test (SRT), symbol digit modalities (SDMT), and word list generation (WLG). Results: The mean gestational age, educational level and account of previous birth of the subjects in the study were not statistically different between the groups. The mean scores of BDI of the 2 groups were not statistically different. MOCA score and SDMT was significantly decreased in GDM in comparison to NP (p=0.005, p=0.04 respectively). Also, SDMT score was inversely correlated with number of pregnancies, postprandial blood glucose and HbA1c.The scores of PASAT, SRT, SPART and WLG were statistically similar between the groups. Conclusions: Our findings may be a clue for early onset of impairment in cognitive functions in cases with new onset diabetes during pregnancy. © Georg Thieme Verlag KG Stuttgart · New York.
Neuro endocrinology letters, 2013
In acromegaly, the gastrointestinal system is under the influence of excessive growth hormone (GH... more In acromegaly, the gastrointestinal system is under the influence of excessive growth hormone (GH) and insulin like growth factor-1 (IGF-I). Increased bowel length and delayed transit time may cause functional disturbance of the bowel. The objective of the current study is to evaluate the frequency of irritable bowel syndrome (IBS) in cases with acromegaly. Twenty-three active cases with acromegaly newly diagnosed between 2010-2011 were included in the study. The control group consisted of ninety gender and age-matched healthy controls (HC). All cases were questioned for presence of IBS using Rome III criteria. Abdominal ultrasonography and colonoscopy results of acromegalic patients were obtained. In addition, cases with acromegaly were evaluated for their quality of life and status of depression by using the Acromegaly Quality of Life Questionnaire (AcroQoL) and Beck Depression Inventory (BDI), respectively. The median GH and IGF-1 levels of cases with acromegaly were 5.72 [IQR: 2...
Turkiye Klinikleri Journal of Medical Sciences, 2014
Tip 2 Diabetes Mellitus'ta Kornea Endotel Morfolojisi, Yoğunluğu ve Merkezi Kornea Kalınlığı Ö ÖZ... more Tip 2 Diabetes Mellitus'ta Kornea Endotel Morfolojisi, Yoğunluğu ve Merkezi Kornea Kalınlığı Ö ÖZ ZE ET T A Am ma aç ç: :Kor ne a en do tel hüc re mor fo lo ji si, yo ğun lu ğu ve mer ke zi kor ne a ka lın lı ğı nın tip 2 di yabe ti olan has ta lar ile di ya be ti ol ma yan sağ lık lı gö nül lü ler le kar şı laş tı rıl ma sı. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu pros pek tif kli nik ça lış ma da, tip 2 di a be tes mel li tus (DM)' lu 30 has ta nın 60 gö zü ile, di ya bet li ol ma yan 51 sağ lık lı gö nül lü nün 102 gö zü ça lış ma ya alın dı. Her bir di ya be tik ol gu için be den kit le in dek si he saplan dı, aç lık kan şeke ri (AKŞ) ve HbA1c dü zey le ri öl çül dü. Kon trol gru bu na, 2 kez ya pı lan AKŞ öl çü mü <100 mg/dL olan sağ lık lı bi rey ler dâhil edil di. En do tel hüc re yo ğun lu ğu (EHY), or ta la ma hüc re bo yutu (OHB), stan dart sap ma (SS), hüc re ala nı var yas yon kat sa yı sı (VK), hek za go na li te yüz de si (HEKY) ve mer ke zi kor ne a ka lın lı ğı (MKK), spe kü ler mik ros kop ile öl çül dü. B Bu ul l g gu u l la ar r: : Tip 2 DM'li grup ile sağ lıklı kon trol le rin yaş or ta la ma la rı (±stan dart sap ma) sı ra sıy la 54,8±9,6 yıl ve 53,3±8,2 yıl idi. Grup lar yaş ve cin si yet açı sın dan ben zer di (sı ra sıy la p=0,454 ve p=0,672). Tip 2 DM'li ol gu lar ile sağ lık lı kon trol ler ara sın da EHY, OHB, SS, VK, HEKY ve MKK açı sın dan is ta tis tik sel ola rak an lam lı bir fark bu lun ma dı (sı ra sıy la p=0,815, p=1,000, p=0,868, p=0,934, p=0,087, p=0,236). Di ya be tik ol gu lar da HbA1c ile MKK ara sın da po zi tif ko re las yon sap tan dı (r=0,297, p=0,026). On yıl dan uzun sü re di ya be ti olan lar da MKK, da ha kı sa sü re li DM'li ol gu la ra gö re da ha faz la ol ma eği li min de idi (sı ra sıy la 537,2±32,0 µm ve 519,0±28,2 µm). An cak bu fark is ta tis tik sel ola rak an lam lı de ğil di (p=0,066). S So o n nu uç ç: : Uzun sü re li ve kon trol süz di ya be ti olan has ta lar da kor ne a en do te lin de mey da na ge le bi le cek ya pı sal de ği şik lik ler, kor ne a kalın lı ğın da ar tı şa yol aça bi lir. Di ya be tik has ta lar DM komp li kas yon la rı açı sın dan iz le nir ken, kro nik hi perg li se mi nin kor ne a üze rin de ki et ki le ri de göz önün de bu lun du rul ma lı dır.
European Journal of Internal Medicine, 2009
Background: Nonalcoholic fatty liver disease (NAFLD) shares similar risk factors with coronary ar... more Background: Nonalcoholic fatty liver disease (NAFLD) shares similar risk factors with coronary artery (CAD). NAFLD is getting more common and present in up to one-third of the Turkish population while Turkish people change their traditional lifestyle nutrutinal behaviors. We aimed to determine if NAFLD has any role in the development of CAD. The other question was the need of screening or surveillance of NAFLD patients for CAD in Turkey. Method: We evaluated the risk factors for CAD and demografic characteristics of NAFLD patients. 34 patients diagnosed with NAFLD by ultrasonography and alcohol cosumption history were enrolled. Demographic and anthropometric parameters, oral glucose tolerance test with insulin levels, transaminase levels, C-reactive protein (CRP) and all components of metabolic syndrome criteria were measured in all patients. The patients were evaluated for CAD by a cardiologist according to guidelines. Results: Elevated transaminase level was found in 37% of NAFLD patients. This increase was significantly associated with body mass index, waist/hip ratio, fasting glucose, hyperinsulinemia, low high density lipoprotein (HDL), male sex, high CRP levels. CAD was found in 32.6% of patients with elevated transaminase and only 10.2% of patients with normal transaminase. Conclusion: These findings strongly suggest that NAFLD is likely to be associated with increased CAD risk. Screening and surveillance stratagies for CAD may be suggested to patients with NAFLD especially when they have elevated transaminases (steatohepatitis) in Turkey.
European Journal of Internal Medicine, 2009
1diabetes (n: 1). In 2 patients the diagnosis of auto-immune disease preceeded the diagnosis of A... more 1diabetes (n: 1). In 2 patients the diagnosis of auto-immune disease preceeded the diagnosis of AIH. In the other cases, the diagnosis of these diseases was concomitant with the hepatopathy. Discussion & conclusion: AIH is frequently associated at least with another autoimmune disease. The presence of disturbance of the hepatic test in the context of autoimmunity must make evoke the diagnosis of AIH. Conversely, they must be systematically looked out in the presence of AIH, in order to avoid the delay diagnosis and therapeutic P0059
European Journal of Internal Medicine, 2009
European Journal of Internal Medicine, 2009
sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alte... more sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alterations of bone density in the right iliac. Abdomino-pelvic ultra-sound showed iliac, lumbo aortic and retrocrural lymphadenopathies. Renal, pelvic, thyroid and breast ultrasound were normal. Laboratory revealed increased LDH (1 372 U/L) and anemia (Hb 11.8 g/dL). Further evaluation showed thrombocytopenia (18 000) and rising values of LDH that reached 4 404U/L. Protein electrophoresis, beta 2 microglobulin and anti-HIV 1 and 2 were negative. Myelogram revealed hypercellular bone marrow with invasion by atypical cells. A CT revealed multiple iliac, retroperitoneal and supraclavicular adenopathies; lytic lesion in the left scapula; lytic mass in the right iliac bone about 12x13 cm, destroying the iliac bone, sacrum and right sacroiliac joint and invading the right gluteus muscle. Histology of CT-guided biopsy of the lesion revealed a ALCL, with CD30, CD4, ALK and EMA positive markers. The final diagnosis was systemic anaplastic lymphoma, stage IV-B, with bone marrow and muscle skeletal involvement. She was medicated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP chemotherapy)and died of sepsis 2 weeks later. Discussion & conclusion: ALK-positive anaplastic large-cell lymphomas have a more favorable prognosis, but staging is also a very important prognostic factor. It is therefore extremely important an early diagnosis. Unfortunately,in this particular case, the patient had a late diagnosis and did succumb to overwhelming infection before the result of chemotherapy could be evaluated.
European Journal of Internal Medicine, 2009
sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alte... more sweating, with painful fusiform tumor in the right hip, about 12x15cm. Pelvis x-ray revealed alterations of bone density in the right iliac. Abdomino-pelvic ultra-sound showed iliac, lumbo aortic and retrocrural lymphadenopathies. Renal, pelvic, thyroid and breast ultrasound were normal. Laboratory revealed increased LDH (1 372 U/L) and anemia (Hb 11.8 g/dL). Further evaluation showed thrombocytopenia (18 000) and rising values of LDH that reached 4 404U/L. Protein electrophoresis, beta 2 microglobulin and anti-HIV 1 and 2 were negative. Myelogram revealed hypercellular bone marrow with invasion by atypical cells. A CT revealed multiple iliac, retroperitoneal and supraclavicular adenopathies; lytic lesion in the left scapula; lytic mass in the right iliac bone about 12x13 cm, destroying the iliac bone, sacrum and right sacroiliac joint and invading the right gluteus muscle. Histology of CT-guided biopsy of the lesion revealed a ALCL, with CD30, CD4, ALK and EMA positive markers. The final diagnosis was systemic anaplastic lymphoma, stage IV-B, with bone marrow and muscle skeletal involvement. She was medicated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP chemotherapy)and died of sepsis 2 weeks later. Discussion & conclusion: ALK-positive anaplastic large-cell lymphomas have a more favorable prognosis, but staging is also a very important prognostic factor. It is therefore extremely important an early diagnosis. Unfortunately,in this particular case, the patient had a late diagnosis and did succumb to overwhelming infection before the result of chemotherapy could be evaluated.
Endocrine Journal, 2013
Female sexual dysFunction (FSD) has many dimensions and may be affected by various factors such a... more Female sexual dysFunction (FSD) has many dimensions and may be affected by various factors such as age, education, chronic diseases, medications, psychological and physical conditions [1]. Dysfunction of the hypothalamic-pituitary axis, hyperprolactinemia, surgical or medical castration, premature ovarian failure, old age and chronic birth control use are common causes of hormonally based FSD [2]. FSD traditionally includes disorders of desire, arousal, pain/discomfort, inhibited orgasm, and satisfaction [3, 4]. Sexual prob
Growth Hormone & IGF Research
Kocatepe Tıp Dergisi
AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi... more AMAÇ: Bu çalışmanın amacı kronik tiroiditli hastalarda nesfatin-1 düzeyi ile tiroid otoimmünitesi arasındaki ilişkiyi değerlendirmektir.GEREÇ VE YÖNTEM: Hashimoto tiroiditli 49 premenopozal kadın ve yaş ve vücut kitle indeksi (VKI) uyumlu 23 sağlıklı kadın, bu kesitsel karşılaştırmalı çalışmaya dahil edildi. Plazma nesfatin-1, açlık ve tokluk glukoz, hemoglobin A1c (HbA1c), açlık insülin, kolesterol parametreleri, serbest tiroksin (ST4), serbest T3 (ST3), tirotropin (TSH), anti-tiroid peroksidaz antikor (anti-TPO) and anti-tiroglobin (anti-TG) antikor değerleri için kan örnekleri alındı. Ek olarak tüm vakalarda, insülin direnci için homeostatik model değerlendirmesi (HOMA-İR) ve vücut kitle indeksi (VKİ) hesaplandı ve bel/kalça oranı ölçüldü.BULGULAR: Hashimoto tiroiditli hastaların ortalama yaşı 35,5±8,1, kontrol grubunun ise 33,2±7,1 idi (p=0.324). VKI ve bel/kalça oranı, gruplar arasında benzerdi (p=0.239 ve p=0.317). TSH, anti-TPO ve anti-TG düzeyleri hasta grubunda anlamlı dere...
Therapeutic advances in endocrinology and metabolism, 2018
It is necessary to stimulate serum thyroid-stimulating hormone (TSH) levels either endogenously b... more It is necessary to stimulate serum thyroid-stimulating hormone (TSH) levels either endogenously by thyroid hormone withdrawal (THW) or exogenously by administration of recombinant human TSH (rhTSH) for radioactive iodine (RAI) therapy. Thyrotropin alfa (Thyrogen) has many advantages over THW. Radiation dose to laboratory staff while drawing blood for tests on the day 5 is one of the disadvantages of preferring Thyrogen. Our aim was to compare day 3 and day 5 blood test results after Thyrogen injections. In our study, Thyrogen was preferred in 32 differentiated thyroid cancer patients with a mean age of 50.5 ± 12.3 years. Thyrogen was injected on day 1 and day 2 intramuscularly in all patients before I-131 was given on day 3. A total of 22 patients received 5 mCi RAI for ablation control scintigraphy and 10 patients received 100-250 mCi RAI for ablation or therapy (high-dose group). Blood tests were performed on day 3 and day 5 after Thyrogen injections. Mean TSH level was 98.1 mg/dl...
African health sciences, 2015
To investigate the relationship between maternal vitamin D status and glucose intolerance, and it... more To investigate the relationship between maternal vitamin D status and glucose intolerance, and its impact on pregnant women and their newborns. A cohort of pregnant women were divided into three groups: women with gestational diabetes mellitus, ones with normal results both after the 50 gr and 100 gr OGTT (CG-1) and ones having a positive result after the 50 gr OGTT screening but negative results for gestational diabetes mellitus (GDM) after the 100 gr OGTT (CG-2). The newborn length in CG-1 was greater than in GDM and CG-2 (p= 0.002 and p= 0.02). Fasting blood glucose and insulin resistance (IR) were negatively correlated with length of the newborns (r=-0.3, p=0.03 and r=-0.3, p=0.01). The newborns of women with GDM had lower APGAR-1 and 5 scores than those of CG-1 and CG-2 (APGAR-1 p= 0.001 and p= 0.004, APGAR-5 p=0.005 and p=0.007, respectively). APGAR scores were correlated negatively with IR (APGAR-1 r=-0.32, p=0.01, APGAR-5 r=-0.3, p=0.03) and positively with 25OHD levels (APG...