The roles of Drosophila cyclins A and B in mitotic control. (original) (raw)
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Cell | 1990
We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle.
Pubmed ID: 2139805 RIS Download
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Associated grants
- Agency: NIGMS NIH HHS, United States
Id: R01 GM037193 - Agency: NIGMS NIH HHS, United States
Id: R01 GM037193-10