Carlos Spuch | Galician National Health Service (original) (raw)

Carlos Spuch

Neuroscientist working in major depression, schizophrenia and dementia

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Papers by Carlos Spuch

Vide Leaf, Hyderabad eBooks, 2020

Frontiers in Psychiatry, May 2, 2022

Alzheimers & Dementia, Jul 1, 2018

Sr.,, Instituto de Neurociencia Cognitiva y Traslacional (Instituto de Neurologica Cognitiva/Nati... more Sr.,, Instituto de Neurociencia Cognitiva y Traslacional (Instituto de Neurologica Cognitiva/National Scientific and Technical Research Council), Buenos Aires, Argentina; Instituto de Neurociencia Cognitiva y Traslacional, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Cient ıficas y T ecnicas, Buenos Aires, Argentina; Neuroscience Institute Favaloro Foundation, Buenos Aires, Argentina; Instituto de Neurologica Cognitiva, Buenos Aires, Argentina. Contact e-mail: mmartinez@ineco.org.ar

Neurobiology of Aging, Nov 1, 2006

F1000Research, May 15, 2012

African journal of rhetoric, Feb 1, 2019

Revista Española de Geriatría y Gerontología, Jun 1, 2018

Nutrients

Human milk is the biological fluid with the highest exosome amount and is rich in microRNAs (miRN... more Human milk is the biological fluid with the highest exosome amount and is rich in microRNAs (miRNAs). These are key regulators of gene expression networks in both normal physiologic and disease contexts, miRNAs can influence many biological processes and have also shown promise as biomarkers for disease. One of the key aspects in the regeneration of the nervous system is that there are practically no molecules that can be used as potential drugs. In the first weeks of lactation, we know that human breast milk must contain the mechanisms to transmit molecular and biological information for brain development. For this reason, our objective is to identify new modulators of the nervous system that can be used to investigate neurodevelopmental functions based on miRNAs. To do this, we collected human breast milk samples according to the time of delivery and milk states: mature milk and colostrum at term; moderate and very preterm mature milk and colostrum; and late preterm mature milk. W...

European Neuropsychopharmacology, 2019

Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2010

Journal of Cell Science, 2009

Neurotoxicity Research, 2010

Alzheimer’s disease (AD) is a progressive degenerative disorder characterized by the presence of ... more Alzheimer’s disease (AD) is a progressive degenerative disorder characterized by the presence of amyloid deposits, neurofibrillary tangles and neuron loss. Emerging evidence indicates that antioxidants could be useful either for the prevention or treatment of AD. Tacrine and melatonin are well-known drugs which act as an acetylcholinesterase inhibitor and a free radical scavenger, respectively. In this study, we evaluated the effects of a new tacrine–melatonin hybrid on behavior and the biochemical and neuropathologic changes observed in amyloid precursor protein/presenilin 1 (APP/Ps1) transgenic mice. Our findings showed that direct intracerebral administration of this hybrid decreased amyloid β peptide (Aβ)-induced cell death and amyloid burden in the brain parenchyma of APP/Ps1 mice. This reduction in Aβ pathology was accompanied by a recovery in cognitive function. Since this tacrine–melatonin hybrid apparently reduces brain Aβ and behavioral deficits, we believe this drug has remarkable and significant neuroprotective effects and might be considered a potential therapeutic strategy in AD.