Adam Funk | The University of Sheffield (original) (raw)

Papers by Adam Funk

Lecture Notes in Computer Science, 2012

Ontology population is a crucial part of knowledge base construction and maintenance that enables... more Ontology population is a crucial part of knowledge base construction and maintenance that enables us to relate text to ontologies, providing on the one hand a customised ontology related to the data and domain with which we are concerned, and on the other hand a ...

... In CLOnE, input sentences are analysed deterministically and composition-ally with respect to... more ... In CLOnE, input sentences are analysed deterministically and composition-ally with respect to a given ontology, which the software consults in order to interpret the input semantics. ... Page 7. SPRAT: a tool for semantic pattern-based ontology population 7 Fig. ...

PloS one, 2015

Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, inclu... more Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels. Abnormalities in cotransporter expression levels could shift the chloride electrochemical gradient and impair GABAergic transmission. In this study, we performed Western blot analysis to investigate whether the Na-K-Cl and K-Cl cotransporter protein is abnormally expressed in the dorsal lateral prefrontal cortex and the anterior cingulate cortex in patients with schizophrenia versus a control group. We found decreased K-Cl cotransporter protein expression in the dorsal lateral prefrontal cortex, but not the anterior cingulate cortex, in subjects with schizophrenia, supporting the hypothesis of region level abnormal GABAergic function in the pathophysiology of schizophrenia. Subjects with schizophrenia off antipsychotic medication at the time of death had decreased K-Cl cotransporter protein ex...

Schizophrenia Research, 2014

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010

Several lines of evidence point to alterations of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-pro... more Several lines of evidence point to alterations of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor trafficking in schizophrenia. Multiple proteins, including synapse-associated protein 97 (SAP97), glutamate receptor-interacting protein 1 (GRIP1), and N-ethylmaleimide sensitive factor (NSF), facilitate the forward trafficking of AMPA receptors toward the synapse. Once localized to the synapse, AMPA receptors are trafficked in a complex endosomal system. We hypothesized that alterations in the expression of these proteins and alterations in the subcellular localization of AMPA receptors in endosomes may contribute to the pathophysiology of schizophrenia. Accordingly, we measured protein expression of SAP97, GRIP1, and NSF in the dorsolateral prefrontal cortex and found an increase in the expression of SAP97 and GRIP1 in schizophrenia. To determine the subcellular localization of AMPA receptor subunits, we developed a technique to isolate early endosomes from post...

AthosMail is a multilingual spoken dialogue system for e-mail message reading on a mobile phone. ... more AthosMail is a multilingual spoken dialogue system for e-mail message reading on a mobile phone. The key features of the application are adaptivity and the integration of different approaches to spoken interaction. The application has a flexible system structure supporting multiple components for both different and the same purposes. The AthosMail system includes components for input interpretation, dialogue management, output

The goal of the work reported here is to pro- vide a system for handling spoken dialogues which c... more The goal of the work reported here is to pro- vide a system for handling spoken dialogues which can be easily ported to new languages and new application areas. This work is be- ing carried within the Dumas project, which aims to explore a number of approaches to this task. The particular approach described here involves involes constructing fairly traditional 'logical forms' on the basis of structural analy- ses of the input speech and then using a mix- ture of meaning postulates, which relate terms in the language to underlying concepts, and gen- eral domain knowledge in order to interpret and respond to what has been said.

NeuroReport, 2009

Converging evidence suggests too few activation-ready N-methyl-D-aspartic acid (NMDA) receptor co... more Converging evidence suggests too few activation-ready N-methyl-D-aspartic acid (NMDA) receptor complexes in the postsynaptic density in schizophrenia. Postsynaptic density protein 95 (PSD95), Synaptic GTPase-activating protein (SynGAP), and Multiple PDZ domain protein (MUPP1) are integral components of the NMDA receptor signaling complex, and help facilitate signaling, trafficking, and stabilization. We hypothesized that deficits involving these molecules may contribute to the pathophysiology of schizophrenia. To test our hypothesis, we measured protein expression of PSD95, SynGAP, and MUPP1 in the anterior cingulate cortex and dorsolateral prefrontal cortex. We found decreased PSD95 expression in the anterior cingulate cortex. Antipsychotic medication analyses showed decreased SynGAP expression in the anterior cingulate cortex in patients off medication when analyzed against our comparison group. These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia.

Neuropsychopharmacology, 2012

Journal of Palliative Medicine, 2009

JONA: The Journal of Nursing Administration, 2007

An established hospital-based nursing research fellowship program was transformed into an evidenc... more An established hospital-based nursing research fellowship program was transformed into an evidence-based practice fellowship despite its previous high satisfaction ratings from nursing leaders and nurse fellow participants. The faculty for the fellowship program determined that the long-term outcomes of the research program were insufficient in light of the hospital resources committed to the fellowship program. An evidence-based practice approach was then created in anticipation that greater short-term and more sustained longer-term benefits for the hospital would be realized. The transformation of the fellowship and the short-term outcomes are described.

Current Pharmaceutical Biotechnology, 2012

The treatment of schizophrenia has been focused on modulation of dopamine receptors for over 50 y... more The treatment of schizophrenia has been focused on modulation of dopamine receptors for over 50 years. Recent developments have implicated other neurotransmitter systems in the pathophysiology of this illness. The discovery and characterization of glutamate receptors and their roles in the brain has lead to novel approaches for the treatment of schizophrenia. In this article, we review drugs that modulate ionotropic gluamate receptors and discuss their efficacy for the treatment of this often debilitating severe mental illness.

Biological Psychiatry, 2009