Ali Hossein Rezayan | University of Tehran (original) (raw)
Papers by Ali Hossein Rezayan
Iranian Journal of Pharmaceutical Research : IJPR, 2017
A series of new fluorene bisamide derivatives were synthesized through multi-component Ugi reacti... more A series of new fluorene bisamide derivatives were synthesized through multi-component Ugi reaction and tested for their in-vitro anti-mycobacterial activity. The structures of the products 5a-w were deduced from their IR, 1H NMR, and 13C NMR spectra. Elemental analyses (CHN) for novel compounds (5a, 5d, 5f, 5h, 5k, 5l, 5p, 5s, 5t, 5v, 5w) was done. These compounds were evaluated as anti-bacterial agents against Mycobacterium bovis and M. tuberculosis, while their activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the twenty-three synthesized compounds, 5a was found to be the most active compound in vitro with MIC of 1.95 μg/mL against Mycobactrium bovis and compound 5k showed greatest potency against sensitive and resistant strains of M. tuberculosis (H37Rv, IHMT149/09, HPV115/08, and HPV65/08).
DARU Journal of Pharmaceutical Sciences, 2012
Background The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has i... more Background The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. Methods This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. Results All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. Conclusions Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Iranian Journal of Medical Microbiology, 2021
Background and Aim: Infectious diseases are one of the leading causes of death in the world. The ... more Background and Aim: Infectious diseases are one of the leading causes of death in the world. The use of antibiotics, in addition to limitations and side effects, causes the resistance of microorganisms. The use of drug delivery systems is an effective way to increase drug stability and reduce antibiotic use. This study aimed to load cefazolin into a niosomal drug delivery system. Materials and Methods: This study was performed in 2018 to investigate the effect of span 60, tween 60, and cholesterol on the synthesis of niosome nanoparticles loaded with cefazolin by the thin layer hydration method. Then the characteristics of synthetic niosome nanoparticles and their antibacterial activity were investigated. Results: Scanning electron microscope (SEM) images showed that all nanoparticles are spherical. The encapsulation efficiencies for the first, second, and third formulations were 33%, 19.7%, and 40.76%, respectively. The release of cefazolin from the first, second, and third formulations during 30 days was 48%, 81.5%, and 63%. The particle size and zeta potential of the third niosome formulation were estimated to be 154 nm and-24 mV. The MIC for Escherichia coli and Staphylococcus aureus were 4 and 150 μg/mL, respectively. The niosome nanoparticles prepared with the third formulation show an excellent antibacterial effect against Escherichia coli for six days, and the diameter of its growth inhibition zone remains almost constant. Conclusion: The optimal formulation of niosome nanoparticles included span 60 (0.060), tween 60 (0.090), and cholesterol (0.046). Continuous and controlled release of cefazolin from the niosome, along with increased drug penetration, reduces the growth of E. coli (ATCC 9637) and S. aureus (ATCC 12600).
ACS Omega
C-reactive protein (CRP), an acute-phase protein synthesized in the liver in response to inflamma... more C-reactive protein (CRP), an acute-phase protein synthesized in the liver in response to inflammation, is one of the biomarkers used for the detection of several diseases. Sepsis and cardiovascular diseases are two of the most important diseases for which detection of CRP at very early stages in the clinical range can help avert serious consequences. Here, a CNT-based nanobiosensing system, which is portable and reproducible, is used for label-free, online detection of CRP. The system consists of an aptameric CNT-based field-effect transistor benefiting from a buried gate geometry with Al 2 O 3 as a high dielectric layer and can reflect the pro-cytokine concentration. Test results show that the device responds to CRP changes within 8 min, with a limit of detection as low as 150 pM (0.017 mg L −1). The device was found to have a linear behavior in the range of 0.43−42.86 nM (0.05−5 mg L −1). The selectivity of the device was tested with TNF-α, IL-6, and BSA, to which the nanosensing system showed no significant response compared with CRP. The device showed good stability for 14 days and was completely reproducible during this period. These findings indicate that the proposed portable system is a potential candidate for CRP measurements in the clinical range.
A highly efficient magnetic Brønsted acid catalyst was synthesized based on immobilization of 2-m... more A highly efficient magnetic Brønsted acid catalyst was synthesized based on immobilization of 2-methylimidazole functionalized by chlorosulfonic acid on the surface of silica-coated magnetic nanoparticles (Fe 3 O 4 @SiO 2 -2mimSO 3 H). The catalyst has an excellent activity and recyclable for at least 6 reaction runs and is proven to be highly effective in the synthesis of α-aminophosphonate compounds in a green way. The facile recovery of the catalyst is carried out by applying an external magnet device. It is both "green" and efficient. The catalyst was fully characterized by techniques of TEM, SEM, FT-IR, TGA, and elemental analysis (CHNS).
DARU Journal of Pharmaceutical Sciences, 2012
Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has ... more Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. Methods: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. Results: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. Conclusions: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Data Revues 16310748 Unassign S1631074812000264, Feb 28, 2012
Comptes Rendus Chimie, 2012
A stereoselective method for the synthesis of 3,4-dihydro-7-nitrocoumarin derivatives via an isoc... more A stereoselective method for the synthesis of 3,4-dihydro-7-nitrocoumarin derivatives via an isocyanide-based four-component reaction is described. The reaction can be carried out as a simple one-pot protocol in good yields without using any catalyst or activator at room temperature in short reaction time.
Communications in Soil Science and Plant Analysis, 2014
ABSTRACT To mitigate environmental problems and synchronize releasing nitrogen (N) with crop dema... more ABSTRACT To mitigate environmental problems and synchronize releasing nitrogen (N) with crop demand, slow-release N fertilizers can be a solution. In this research, the mechanism of the N immobilization in stable sources (not unstable sources such as microbial biomass and extractable organic N) for finding an appropriate compound in designing a slow-release N fertilizer was investigated. The experiments were carried out in a randomized complete block design using an incubation chamber to study the N mineralization in coarse and fine fractions of yellow lupin, blue lupin, and faba bean. The results showed that the major N immobilization occurred at 10 to 17 days after incubation. At this phase, only the polyphenols had a significant correlation coefficient with the N immobilization (r = 0.80). At 17 to 31 and 31 to 61 days after incubation, the N immobilization had significant relationship with cellulose (r = 0.96) and hemicellulose (r = 0.89), respectively. It seems that with advancing incubation time, cellulose and hemicellulose were released from cell walls, and similarly to polyphenol were bound to nitrate N (NO3−-N), ammonium N (NH4+-N), or extractable organic N through different interactions. Although the main mechanisms of N immobilization in soil after adding plant materials with a high carbon (C)/N ratio are described in the literature, the available data do not yet present an appropriate composition of targeted, innovative, and slow-release N fertilizers. According to the obtained results, tests are suggested to find the optimum nitrification inhibitor using the powder of plant residues with different ratios of these compounds incorporated with inorganic fertilizers.
Journal of Fluorescence, 2015
In this paper, a new approach for microRNA-155 (miRNA-155) detection was described based on the f... more In this paper, a new approach for microRNA-155 (miRNA-155) detection was described based on the fluorescence quenching of oligonucleotide-templated silver nanoclusters (DNA-AgNCs). The specific DNA scaffold with two different nucleotides fragments were used: one was enriched with a cytosine sequence fragment (C12) that could result in DNA-AgNCs with a high quantum yield via a chemical reduction method, and the other was the probe fragment (5-CUGUUAAUGCUAAUCGUG-3) which could selectively bind to the miRNA-155. Thus, the as-prepared AgNCs could exhibit quenched fluorescence when binding to the target miRNA-155. The fluorescence ratio of the DNA-AgNCs was quenched in a linearly proportional manner to the concentration of the target in the range of 0.2 nM to 30 nM with a detection limit of 0.1 nM.
Journal of the Iranian Chemical Society, 2013
ABSTRACT A simple and eco-friendly synthesis of the biologically important spirooxindole scaffold... more ABSTRACT A simple and eco-friendly synthesis of the biologically important spirooxindole scaffold was done by the reaction of isatin with activated pyrazolones in the presence of a catalytic amount of p-toluenesulfonic acid in water at room temperature. A variety of symmetrical spirooxindole derivatives were obtained with excellent yields within short reaction time. This method is of great value because of its environmentally benign character, high yield, and easy handling.
Chemical Biology & Drug Design, 2012
The coumarin compounds are an important class of biologically active molecules, which have attrac... more The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one-pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide-based multicomponent condensation reactions. These compounds were evaluated for anti-mycobacterium activity against Mycobacterium bovis (Bacillus Calmette-Guerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti-tuberculosis activity.
Acta Crystallographica Section E Structure Reports Online, 2012
Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.003 Å; R factor = 0.053; wR... more Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.003 Å; R factor = 0.053; wR factor = 0.128; data-to-parameter ratio = 19.0. organic compounds o2154 Feizi et al.
Monatshefte Fuer Chemie Chemical Monthly, Jul 9, 2008
1-Butyl-3-methylimidazolium chloride ([bmim]Cl) in the absence of any catalyst mediated the selec... more 1-Butyl-3-methylimidazolium chloride ([bmim]Cl) in the absence of any catalyst mediated the selective deprotection of benzyl and phenyl trimethylsilyl (TMS) ethers to the corresponding alcohols and phenol in good yields at room temperature even in presence of alkyl silyl ethers. The work-up of reactions is very simple and the products do not require further purification. The ionic liquid (IL) can be recycled and reused for several runs without any significant loss of activity.
Chemical and Pharmaceutical Bulletin, Feb 1, 2010
Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activat... more Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activated CH-acid compounds are described. These reactions afford the corresponding pyran annulated heterocyclic ring systems in high yields at room temperature within a few minutes. The work-up procedure is very simple and the products do not require further purification. The catalyst can be recycled and reused for several times without observable loss of performance.
Tetrahedron, Mar 6, 2010
A new class of pyridinium, quinolinium, isoquinolinum, and N-methylimidazolium-3-(2,5-dihydro-5-o... more A new class of pyridinium, quinolinium, isoquinolinum, and N-methylimidazolium-3-(2,5-dihydro-5-oxofuran-3-yl)-4-hydroxyfuran-2(5H)-one salts have been prepared in high yields by reacting pyridine, quinoline, isoquinoline, N-methylimidazole, 1,4-diazabicyclo[2.2.2]octane, and their derivatives with tetronic acid in CH2Cl2.
Data Revues 16310748 V12i12 S1631074809000617, Feb 12, 2009
The Journal of Organic Chemistry, May 1, 2009
The reactive intermediates generated by the addition of alkyl, aryl, and alicyclic isocyanides to... more The reactive intermediates generated by the addition of alkyl, aryl, and alicyclic isocyanides to dialkyl acetylenedicarboxylates were trapped by 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione or 2-hydroxynaphthalene-1,4-dione to produce highly functionalized bis(4H-chromene)- and 4H-benzo[g]chromene-3,4-dicarboxylate derivatives in fairly good yields in CH(3)CN at room temperature. These compounds are closely related to the ring systems pentalongin, dehydroherbarin, 1,3-disubstituted-3,4-dehydropyranonaphthoquinones, and 3-arylpyranonaphthoquinones, which have a broad spectrum of biological activity.
![Research paper thumbnail of A simple and efficient approach to the synthesis of 4H-furo[3,4-b]pyrans via a three-component reaction of isocyanides](https://attachments.academia-assets.com/46337510/thumbnails/1.jpg)
](Bioorganic Medicinal Chemistry Letters, Aug 1, 2008
A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid ... more A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo[3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity.
ChemInform, 2009
Nitriles Q 0520 Meldrum's Acid Catalyzed Reaction of Tetracyanoethylene and Aldehydes in Water: A... more Nitriles Q 0520 Meldrum's Acid Catalyzed Reaction of Tetracyanoethylene and Aldehydes in Water: A Novel Approach to Arylidenemalononitrile. -The title arylidenemalononitriles are efficiently obtained from various aromatic, heteroaromatic, and conjugated aldehydes. -(SHAABANI*, A.; REZAYAN, A. H.; HEIDARY, M.; SARVARY, A.; Chem.
Iranian Journal of Pharmaceutical Research : IJPR, 2017
A series of new fluorene bisamide derivatives were synthesized through multi-component Ugi reacti... more A series of new fluorene bisamide derivatives were synthesized through multi-component Ugi reaction and tested for their in-vitro anti-mycobacterial activity. The structures of the products 5a-w were deduced from their IR, 1H NMR, and 13C NMR spectra. Elemental analyses (CHN) for novel compounds (5a, 5d, 5f, 5h, 5k, 5l, 5p, 5s, 5t, 5v, 5w) was done. These compounds were evaluated as anti-bacterial agents against Mycobacterium bovis and M. tuberculosis, while their activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. Among the twenty-three synthesized compounds, 5a was found to be the most active compound in vitro with MIC of 1.95 μg/mL against Mycobactrium bovis and compound 5k showed greatest potency against sensitive and resistant strains of M. tuberculosis (H37Rv, IHMT149/09, HPV115/08, and HPV65/08).
DARU Journal of Pharmaceutical Sciences, 2012
Background The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has i... more Background The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. Methods This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. Results All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. Conclusions Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Iranian Journal of Medical Microbiology, 2021
Background and Aim: Infectious diseases are one of the leading causes of death in the world. The ... more Background and Aim: Infectious diseases are one of the leading causes of death in the world. The use of antibiotics, in addition to limitations and side effects, causes the resistance of microorganisms. The use of drug delivery systems is an effective way to increase drug stability and reduce antibiotic use. This study aimed to load cefazolin into a niosomal drug delivery system. Materials and Methods: This study was performed in 2018 to investigate the effect of span 60, tween 60, and cholesterol on the synthesis of niosome nanoparticles loaded with cefazolin by the thin layer hydration method. Then the characteristics of synthetic niosome nanoparticles and their antibacterial activity were investigated. Results: Scanning electron microscope (SEM) images showed that all nanoparticles are spherical. The encapsulation efficiencies for the first, second, and third formulations were 33%, 19.7%, and 40.76%, respectively. The release of cefazolin from the first, second, and third formulations during 30 days was 48%, 81.5%, and 63%. The particle size and zeta potential of the third niosome formulation were estimated to be 154 nm and-24 mV. The MIC for Escherichia coli and Staphylococcus aureus were 4 and 150 μg/mL, respectively. The niosome nanoparticles prepared with the third formulation show an excellent antibacterial effect against Escherichia coli for six days, and the diameter of its growth inhibition zone remains almost constant. Conclusion: The optimal formulation of niosome nanoparticles included span 60 (0.060), tween 60 (0.090), and cholesterol (0.046). Continuous and controlled release of cefazolin from the niosome, along with increased drug penetration, reduces the growth of E. coli (ATCC 9637) and S. aureus (ATCC 12600).
ACS Omega
C-reactive protein (CRP), an acute-phase protein synthesized in the liver in response to inflamma... more C-reactive protein (CRP), an acute-phase protein synthesized in the liver in response to inflammation, is one of the biomarkers used for the detection of several diseases. Sepsis and cardiovascular diseases are two of the most important diseases for which detection of CRP at very early stages in the clinical range can help avert serious consequences. Here, a CNT-based nanobiosensing system, which is portable and reproducible, is used for label-free, online detection of CRP. The system consists of an aptameric CNT-based field-effect transistor benefiting from a buried gate geometry with Al 2 O 3 as a high dielectric layer and can reflect the pro-cytokine concentration. Test results show that the device responds to CRP changes within 8 min, with a limit of detection as low as 150 pM (0.017 mg L −1). The device was found to have a linear behavior in the range of 0.43−42.86 nM (0.05−5 mg L −1). The selectivity of the device was tested with TNF-α, IL-6, and BSA, to which the nanosensing system showed no significant response compared with CRP. The device showed good stability for 14 days and was completely reproducible during this period. These findings indicate that the proposed portable system is a potential candidate for CRP measurements in the clinical range.
A highly efficient magnetic Brønsted acid catalyst was synthesized based on immobilization of 2-m... more A highly efficient magnetic Brønsted acid catalyst was synthesized based on immobilization of 2-methylimidazole functionalized by chlorosulfonic acid on the surface of silica-coated magnetic nanoparticles (Fe 3 O 4 @SiO 2 -2mimSO 3 H). The catalyst has an excellent activity and recyclable for at least 6 reaction runs and is proven to be highly effective in the synthesis of α-aminophosphonate compounds in a green way. The facile recovery of the catalyst is carried out by applying an external magnet device. It is both "green" and efficient. The catalyst was fully characterized by techniques of TEM, SEM, FT-IR, TGA, and elemental analysis (CHNS).
DARU Journal of Pharmaceutical Sciences, 2012
Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has ... more Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. Methods: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. Results: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. Conclusions: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Data Revues 16310748 Unassign S1631074812000264, Feb 28, 2012
Comptes Rendus Chimie, 2012
A stereoselective method for the synthesis of 3,4-dihydro-7-nitrocoumarin derivatives via an isoc... more A stereoselective method for the synthesis of 3,4-dihydro-7-nitrocoumarin derivatives via an isocyanide-based four-component reaction is described. The reaction can be carried out as a simple one-pot protocol in good yields without using any catalyst or activator at room temperature in short reaction time.
Communications in Soil Science and Plant Analysis, 2014
ABSTRACT To mitigate environmental problems and synchronize releasing nitrogen (N) with crop dema... more ABSTRACT To mitigate environmental problems and synchronize releasing nitrogen (N) with crop demand, slow-release N fertilizers can be a solution. In this research, the mechanism of the N immobilization in stable sources (not unstable sources such as microbial biomass and extractable organic N) for finding an appropriate compound in designing a slow-release N fertilizer was investigated. The experiments were carried out in a randomized complete block design using an incubation chamber to study the N mineralization in coarse and fine fractions of yellow lupin, blue lupin, and faba bean. The results showed that the major N immobilization occurred at 10 to 17 days after incubation. At this phase, only the polyphenols had a significant correlation coefficient with the N immobilization (r = 0.80). At 17 to 31 and 31 to 61 days after incubation, the N immobilization had significant relationship with cellulose (r = 0.96) and hemicellulose (r = 0.89), respectively. It seems that with advancing incubation time, cellulose and hemicellulose were released from cell walls, and similarly to polyphenol were bound to nitrate N (NO3−-N), ammonium N (NH4+-N), or extractable organic N through different interactions. Although the main mechanisms of N immobilization in soil after adding plant materials with a high carbon (C)/N ratio are described in the literature, the available data do not yet present an appropriate composition of targeted, innovative, and slow-release N fertilizers. According to the obtained results, tests are suggested to find the optimum nitrification inhibitor using the powder of plant residues with different ratios of these compounds incorporated with inorganic fertilizers.
Journal of Fluorescence, 2015
In this paper, a new approach for microRNA-155 (miRNA-155) detection was described based on the f... more In this paper, a new approach for microRNA-155 (miRNA-155) detection was described based on the fluorescence quenching of oligonucleotide-templated silver nanoclusters (DNA-AgNCs). The specific DNA scaffold with two different nucleotides fragments were used: one was enriched with a cytosine sequence fragment (C12) that could result in DNA-AgNCs with a high quantum yield via a chemical reduction method, and the other was the probe fragment (5-CUGUUAAUGCUAAUCGUG-3) which could selectively bind to the miRNA-155. Thus, the as-prepared AgNCs could exhibit quenched fluorescence when binding to the target miRNA-155. The fluorescence ratio of the DNA-AgNCs was quenched in a linearly proportional manner to the concentration of the target in the range of 0.2 nM to 30 nM with a detection limit of 0.1 nM.
Journal of the Iranian Chemical Society, 2013
ABSTRACT A simple and eco-friendly synthesis of the biologically important spirooxindole scaffold... more ABSTRACT A simple and eco-friendly synthesis of the biologically important spirooxindole scaffold was done by the reaction of isatin with activated pyrazolones in the presence of a catalytic amount of p-toluenesulfonic acid in water at room temperature. A variety of symmetrical spirooxindole derivatives were obtained with excellent yields within short reaction time. This method is of great value because of its environmentally benign character, high yield, and easy handling.
Chemical Biology & Drug Design, 2012
The coumarin compounds are an important class of biologically active molecules, which have attrac... more The coumarin compounds are an important class of biologically active molecules, which have attractive caught the attention of many organic and medicinal chemists, due to potential pharmaceutical implications and industrial applications. We herein report the one-pot procedure for the efficient synthesis of coumarin derivatives using commercially available substrates via isocyanide-based multicomponent condensation reactions. These compounds were evaluated for anti-mycobacterium activity against Mycobacterium bovis (Bacillus Calmette-Guerin). The preliminary results indicated that all of the tested compounds showed relatively good activity against the test organism. The compounds 7e, 7l, and 7m showed high anti-tuberculosis activity.
Acta Crystallographica Section E Structure Reports Online, 2012
Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.003 Å; R factor = 0.053; wR... more Key indicators: single-crystal X-ray study; T = 298 K; mean (C-C) = 0.003 Å; R factor = 0.053; wR factor = 0.128; data-to-parameter ratio = 19.0. organic compounds o2154 Feizi et al.
Monatshefte Fuer Chemie Chemical Monthly, Jul 9, 2008
1-Butyl-3-methylimidazolium chloride ([bmim]Cl) in the absence of any catalyst mediated the selec... more 1-Butyl-3-methylimidazolium chloride ([bmim]Cl) in the absence of any catalyst mediated the selective deprotection of benzyl and phenyl trimethylsilyl (TMS) ethers to the corresponding alcohols and phenol in good yields at room temperature even in presence of alkyl silyl ethers. The work-up of reactions is very simple and the products do not require further purification. The ionic liquid (IL) can be recycled and reused for several runs without any significant loss of activity.
Chemical and Pharmaceutical Bulletin, Feb 1, 2010
Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activat... more Pyridine-functionalized MCM-41 catalyzed reactions between tetracyanoethylene and various activated CH-acid compounds are described. These reactions afford the corresponding pyran annulated heterocyclic ring systems in high yields at room temperature within a few minutes. The work-up procedure is very simple and the products do not require further purification. The catalyst can be recycled and reused for several times without observable loss of performance.
Tetrahedron, Mar 6, 2010
A new class of pyridinium, quinolinium, isoquinolinum, and N-methylimidazolium-3-(2,5-dihydro-5-o... more A new class of pyridinium, quinolinium, isoquinolinum, and N-methylimidazolium-3-(2,5-dihydro-5-oxofuran-3-yl)-4-hydroxyfuran-2(5H)-one salts have been prepared in high yields by reacting pyridine, quinoline, isoquinoline, N-methylimidazole, 1,4-diazabicyclo[2.2.2]octane, and their derivatives with tetronic acid in CH2Cl2.
Data Revues 16310748 V12i12 S1631074809000617, Feb 12, 2009
The Journal of Organic Chemistry, May 1, 2009
The reactive intermediates generated by the addition of alkyl, aryl, and alicyclic isocyanides to... more The reactive intermediates generated by the addition of alkyl, aryl, and alicyclic isocyanides to dialkyl acetylenedicarboxylates were trapped by 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione or 2-hydroxynaphthalene-1,4-dione to produce highly functionalized bis(4H-chromene)- and 4H-benzo[g]chromene-3,4-dicarboxylate derivatives in fairly good yields in CH(3)CN at room temperature. These compounds are closely related to the ring systems pentalongin, dehydroherbarin, 1,3-disubstituted-3,4-dehydropyranonaphthoquinones, and 3-arylpyranonaphthoquinones, which have a broad spectrum of biological activity.
Bioorganic Medicinal Chemistry Letters, Aug 1, 2008
A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid ... more A three-component reaction of an isocyanide, a dialkyl acetylenedicarboxylate, and tetronic acid in dichloromethane at room temperature afforded 4H-furo[3,4-b]pyran derivatives. These compounds are closely related with ring systems, TAN-2483B, TAN-2483A, and FD-211 which have a broad spectrum of biological activity.
ChemInform, 2009
Nitriles Q 0520 Meldrum's Acid Catalyzed Reaction of Tetracyanoethylene and Aldehydes in Water: A... more Nitriles Q 0520 Meldrum's Acid Catalyzed Reaction of Tetracyanoethylene and Aldehydes in Water: A Novel Approach to Arylidenemalononitrile. -The title arylidenemalononitriles are efficiently obtained from various aromatic, heteroaromatic, and conjugated aldehydes. -(SHAABANI*, A.; REZAYAN, A. H.; HEIDARY, M.; SARVARY, A.; Chem.