Colin Buttimer | University College Cork (original) (raw)
My current research focuses on the isolation and characterisation of bacteriophages against bacteria in the human gut.
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National Research University Higher School of Economics
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Papers by Colin Buttimer
Identification and Characterisation of Novel Phages of Pectobacterium and Erwinia, 2018
Losses in crop yields due to disease need to be reduced to meet increasing global food demands as... more Losses in crop yields due to disease need to be reduced to meet increasing global food demands associated with growth in the human population. There is a well-recognised need to develop new environmentally-friendly control strategies to combat bacterial crop diseases. There are several crop diseases for which no effective bactericidal agents are currently available, such as potato blackleg and soft rot disease caused by Pectobacterium atrosepticum and other members of soft rot Enterobacteriaceae. Furthermore, current control measures involving traditional chemicals or antibiotics are losing their efficacy due to the natural development of bacterial resistance to these agents, as seen for fire blight of the pear and apple tree caused by Erwinia amylovora. Bacteriophages (phage), the viruses of bacteria, have received increased research interest in recent years as an environmentally friendly means of controlling bacterial diseases. However, not all phages possess the features that enable them to be effective bactericidal agents. To this end, this thesis provides a detailed study of phages that infect Pectobacterium atrosepticum and Erwinia amylovora. The knowledge gained in the execution of this PhD thesis contributes to the pool of knowledge about the lifestyles of the phages examined, thus enabling a more informed choice regarding selecting suitable phages for biocontrol applications for the relevant phytopathogens.
Identification and Characterisation of Novel Phages of Pectobacterium and Erwinia, 2018
Losses in crop yields due to disease need to be reduced to meet increasing global food demands as... more Losses in crop yields due to disease need to be reduced to meet increasing global food demands associated with growth in the human population. There is a well-recognised need to develop new environmentally-friendly control strategies to combat bacterial crop diseases. There are several crop diseases for which no effective bactericidal agents are currently available, such as potato blackleg and soft rot disease caused by Pectobacterium atrosepticum and other members of soft rot Enterobacteriaceae. Furthermore, current control measures involving traditional chemicals or antibiotics are losing their efficacy due to the natural development of bacterial resistance to these agents, as seen for fire blight of the pear and apple tree caused by Erwinia amylovora. Bacteriophages (phage), the viruses of bacteria, have received increased research interest in recent years as an environmentally friendly means of controlling bacterial diseases. However, not all phages possess the features that enable them to be effective bactericidal agents. To this end, this thesis provides a detailed study of phages that infect Pectobacterium atrosepticum and Erwinia amylovora. The knowledge gained in the execution of this PhD thesis contributes to the pool of knowledge about the lifestyles of the phages examined, thus enabling a more informed choice regarding selecting suitable phages for biocontrol applications for the relevant phytopathogens.