Philip Darney | University of California, San Francisco (original) (raw)

Papers by Philip Darney

Research paper thumbnail of Race, adolescent contraceptive choice, and pregnancy at presentation to a family planning clinic

Obstetrics & Gynecology, Feb 1, 2002

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Research paper thumbnail of Financial Effect of Instituting Deficit Reduction Act Documentation Requirements in Family Planning Clinics in Oregon

Obstetrical & Gynecological Survey, Sep 1, 2011

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Research paper thumbnail of A Randomized Controlled Trial of Laminaria, Oral Misoprostol, and Vaginal Misoprostol Before Abortion

Obstetrics & Gynecology, May 1, 1999

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Research paper thumbnail of Successful pregnancy outcome after cervical dilation with multiple laminaria tents in preparation for second-trimester elective abortion: A report of two cases

American Journal of Obstetrics and Gynecology, Mar 1, 1987

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Research paper thumbnail of Subcutaneous DMPA vs. intramuscular DMPA: a 2-year randomized study of contraceptive efficacy and bone mineral density

Contraception, Jul 1, 2009

A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutan... more A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutaneous injection (104 mg/0.65 mL; DMPA-SC) and achieves highly effective contraception with a similar tolerability profile to intramuscular DMPA (150 mg/mL; DMPA-IM). This randomized, evaluator-blinded study was designed to compare efficacy, safety, and user satisfaction in women receiving DMPA-SC (n=266) or DMPA-IM (n=268) for 2 years with an option to continue for a third year. The primary objectives were to evaluate bone mineral density (BMD) changes and contraceptive efficacy after 2 years. A total of 225 women completed the first 2 years of this study (DMPA-SC, n=116; DMPA-IM, n=109). After 2 years of DMPA use, BMD loss was marginally smaller in the DMPA-SC group than in the DMPA-IM group at both the total hip (-3.3% and -3.6%, respectively) and lumbar spine (-4.3% and -5.0%, respectively). In those women who received DMPA during the third year, there were no statistically significant differences in BMD loss between DMPA-SC and DMPA-IM groups at the end of Year 3. Recovery of BMD was observed in the small subpopulation of women who had discontinued DMPA-SC or DMPA-IM after the second year. The 2-year treatment-failure cumulative pregnancy rate was 0% in the DMPA-SC group and 0.8% (95% confidence interval, 0.00-2.37%) in the DMPA-IM group (life-table method). Adverse events were similar in the two groups except that injection site reactions were more common in the DMPA-SC group. DMPA-SC is an effective and well-tolerated contraceptive option, providing comparable efficacy and BMD safety to DMPA-IM.

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Research paper thumbnail of Contraceptive Implants

Wiley-Blackwell eBooks, Feb 18, 2011

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Research paper thumbnail of Impact of Integrated Family Planning Training

Cambridge University Press eBooks, Aug 19, 2021

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Research paper thumbnail of Contraceptive choices for behaviorally disordered women

International journal of gynaecology and obstetrics, Mar 1, 1994

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Research paper thumbnail of Book Review Clinical Pediatric and Adolescent Gynecology Edited by Joseph S. Sanfilippo, Eduardo Lara-Torre, D. Keith Edmonds, and Claire Templeman. 450 pp., illustrated, with CD-ROM. New York, Informa Healthcare, 2009. $299.95. 978-0-415-44888-8

The New England Journal of Medicine, Aug 20, 2009

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Research paper thumbnail of Adolescentsʼ Contraceptive Use and Pregnancy History

Obstetrics & Gynecology, Mar 1, 2003

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Research paper thumbnail of Reply to Dr. Iffy

American Journal of Obstetrics and Gynecology, Nov 1, 1980

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Research paper thumbnail of Attitudes of Married College Students on Overpopulation and Family Planning

Public health reports, 1970

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Research paper thumbnail of The Supreme Court joins the multispecialty group practice of the Congress and the President

Obstetrics & Gynecology, Aug 1, 2007

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Research paper thumbnail of Hormonal implants: Contraception for a new century

American Journal of Obstetrics and Gynecology, May 1, 1994

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Research paper thumbnail of Preparation of the Cervix: Hydrophilic and Prostaglandin Dilators

Clinics in obstetrics and gynaecology, Mar 1, 1986

The use of laminaria has made possible safe uterine evacuation in the second-trimester and has be... more The use of laminaria has made possible safe uterine evacuation in the second-trimester and has been identified as a protective factor in the prevention of uterine perforation in first-trimester abortion. Two additional approaches to cervical dilation are now available - synthetic hydrophilic dilators and prostaglandin analogues. Neither has been in use long enough to undergo thorough evaluation, but it seems possible that they may confer similar advantages while avoiding the discomfort and inconvenience associated with laminaria. New approaches to the use of laminaria have increased their value as cervical dilators. They may be left in the cervix for 6-48 hours. Multiple sets may be employed to achieve adequate cervical dilation for late second-trimester uterine evacuation. When fetal membranes are intact, prolonged use or multiple insertions of laminaria do not appear to increase rates of post-abortion infection. Lamicel and Dilapan are new synthetic dilators which affect the cervix much more rapidly than laminaria. The former does not apply radial force to the walls of the cervical canal, but the latter does. Significant dilation may be achieved in a few hours. Prostaglandins can also alter the cervix in only a few hours. Meteneprost appears to do so with minimal gastrointestinal side-effects and with a low risk of bleeding or abortion.

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Research paper thumbnail of Early surgical abortion: An alternative to and backup for medical abortion

American Journal of Obstetrics and Gynecology, Aug 1, 2000

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Research paper thumbnail of Implant Contraception

Seminars in Reproductive Medicine, 2001

The experience of 6 million Norplant users has led to several more advanced implants. Implanon is... more The experience of 6 million Norplant users has led to several more advanced implants. Implanon is a single-rod implant system containing a low androgenic progestin and requires 1 to 2 minutes for insertion and removal. Like other implants, Implanon prevents pregnancy by changing the character of the cervical mucus and interfering with luteal function. Unlike Norplant, though, Implanon is designed to prevent ovulation for the full duration of use. Implant contraception has several advantages over other types of contraception including high efficacy, minimal required maintenance, absence of estrogen, and rapid return of fertility after discontinuation. Implants can be a good choice for adolescents; women with hypertension, diabetes, anemia, endometriosis, or other medical problems; and women who are breast-feeding. Irregular bleeding is the most common adverse effect of implants and can be treated with several medication regimens. Preinsertion counseling, however, is the most important factor in ensuring satisfaction with implants. Unfortunately, no implant system is currently available in the United States since August 2000, but Implanon is expected to reach the U.S. market within the next 2 years.

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Research paper thumbnail of Abortion Training in U.S. Obstetrics and Gynecology Residency Programs

Family Planning Perspectives, Jul 1, 1987

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Research paper thumbnail of Recent developments in hormone delivery systems

American Journal of Obstetrics and Gynecology, Apr 1, 2004

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Research paper thumbnail of Vaginal ring contraception

Contraception, Feb 1, 2011

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Research paper thumbnail of Race, adolescent contraceptive choice, and pregnancy at presentation to a family planning clinic

Obstetrics & Gynecology, Feb 1, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Financial Effect of Instituting Deficit Reduction Act Documentation Requirements in Family Planning Clinics in Oregon

Obstetrical & Gynecological Survey, Sep 1, 2011

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Research paper thumbnail of A Randomized Controlled Trial of Laminaria, Oral Misoprostol, and Vaginal Misoprostol Before Abortion

Obstetrics & Gynecology, May 1, 1999

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Successful pregnancy outcome after cervical dilation with multiple laminaria tents in preparation for second-trimester elective abortion: A report of two cases

American Journal of Obstetrics and Gynecology, Mar 1, 1987

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Subcutaneous DMPA vs. intramuscular DMPA: a 2-year randomized study of contraceptive efficacy and bone mineral density

Contraception, Jul 1, 2009

A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutan... more A formulation of depot medroxyprogesterone acetate (DMPA) has been developed that allows subcutaneous injection (104 mg/0.65 mL; DMPA-SC) and achieves highly effective contraception with a similar tolerability profile to intramuscular DMPA (150 mg/mL; DMPA-IM). This randomized, evaluator-blinded study was designed to compare efficacy, safety, and user satisfaction in women receiving DMPA-SC (n=266) or DMPA-IM (n=268) for 2 years with an option to continue for a third year. The primary objectives were to evaluate bone mineral density (BMD) changes and contraceptive efficacy after 2 years. A total of 225 women completed the first 2 years of this study (DMPA-SC, n=116; DMPA-IM, n=109). After 2 years of DMPA use, BMD loss was marginally smaller in the DMPA-SC group than in the DMPA-IM group at both the total hip (-3.3% and -3.6%, respectively) and lumbar spine (-4.3% and -5.0%, respectively). In those women who received DMPA during the third year, there were no statistically significant differences in BMD loss between DMPA-SC and DMPA-IM groups at the end of Year 3. Recovery of BMD was observed in the small subpopulation of women who had discontinued DMPA-SC or DMPA-IM after the second year. The 2-year treatment-failure cumulative pregnancy rate was 0% in the DMPA-SC group and 0.8% (95% confidence interval, 0.00-2.37%) in the DMPA-IM group (life-table method). Adverse events were similar in the two groups except that injection site reactions were more common in the DMPA-SC group. DMPA-SC is an effective and well-tolerated contraceptive option, providing comparable efficacy and BMD safety to DMPA-IM.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Contraceptive Implants

Wiley-Blackwell eBooks, Feb 18, 2011

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Research paper thumbnail of Impact of Integrated Family Planning Training

Cambridge University Press eBooks, Aug 19, 2021

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Contraceptive choices for behaviorally disordered women

International journal of gynaecology and obstetrics, Mar 1, 1994

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Book Review Clinical Pediatric and Adolescent Gynecology Edited by Joseph S. Sanfilippo, Eduardo Lara-Torre, D. Keith Edmonds, and Claire Templeman. 450 pp., illustrated, with CD-ROM. New York, Informa Healthcare, 2009. $299.95. 978-0-415-44888-8

The New England Journal of Medicine, Aug 20, 2009

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Research paper thumbnail of Adolescentsʼ Contraceptive Use and Pregnancy History

Obstetrics & Gynecology, Mar 1, 2003

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Research paper thumbnail of Reply to Dr. Iffy

American Journal of Obstetrics and Gynecology, Nov 1, 1980

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Research paper thumbnail of Attitudes of Married College Students on Overpopulation and Family Planning

Public health reports, 1970

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The Supreme Court joins the multispecialty group practice of the Congress and the President

Obstetrics & Gynecology, Aug 1, 2007

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Research paper thumbnail of Hormonal implants: Contraception for a new century

American Journal of Obstetrics and Gynecology, May 1, 1994

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Preparation of the Cervix: Hydrophilic and Prostaglandin Dilators

Clinics in obstetrics and gynaecology, Mar 1, 1986

The use of laminaria has made possible safe uterine evacuation in the second-trimester and has be... more The use of laminaria has made possible safe uterine evacuation in the second-trimester and has been identified as a protective factor in the prevention of uterine perforation in first-trimester abortion. Two additional approaches to cervical dilation are now available - synthetic hydrophilic dilators and prostaglandin analogues. Neither has been in use long enough to undergo thorough evaluation, but it seems possible that they may confer similar advantages while avoiding the discomfort and inconvenience associated with laminaria. New approaches to the use of laminaria have increased their value as cervical dilators. They may be left in the cervix for 6-48 hours. Multiple sets may be employed to achieve adequate cervical dilation for late second-trimester uterine evacuation. When fetal membranes are intact, prolonged use or multiple insertions of laminaria do not appear to increase rates of post-abortion infection. Lamicel and Dilapan are new synthetic dilators which affect the cervix much more rapidly than laminaria. The former does not apply radial force to the walls of the cervical canal, but the latter does. Significant dilation may be achieved in a few hours. Prostaglandins can also alter the cervix in only a few hours. Meteneprost appears to do so with minimal gastrointestinal side-effects and with a low risk of bleeding or abortion.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Early surgical abortion: An alternative to and backup for medical abortion

American Journal of Obstetrics and Gynecology, Aug 1, 2000

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Implant Contraception

Seminars in Reproductive Medicine, 2001

The experience of 6 million Norplant users has led to several more advanced implants. Implanon is... more The experience of 6 million Norplant users has led to several more advanced implants. Implanon is a single-rod implant system containing a low androgenic progestin and requires 1 to 2 minutes for insertion and removal. Like other implants, Implanon prevents pregnancy by changing the character of the cervical mucus and interfering with luteal function. Unlike Norplant, though, Implanon is designed to prevent ovulation for the full duration of use. Implant contraception has several advantages over other types of contraception including high efficacy, minimal required maintenance, absence of estrogen, and rapid return of fertility after discontinuation. Implants can be a good choice for adolescents; women with hypertension, diabetes, anemia, endometriosis, or other medical problems; and women who are breast-feeding. Irregular bleeding is the most common adverse effect of implants and can be treated with several medication regimens. Preinsertion counseling, however, is the most important factor in ensuring satisfaction with implants. Unfortunately, no implant system is currently available in the United States since August 2000, but Implanon is expected to reach the U.S. market within the next 2 years.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abortion Training in U.S. Obstetrics and Gynecology Residency Programs

Family Planning Perspectives, Jul 1, 1987

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Recent developments in hormone delivery systems

American Journal of Obstetrics and Gynecology, Apr 1, 2004

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Vaginal ring contraception

Contraception, Feb 1, 2011

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