Cesar Busato | Universidade Estadual de Ponta Grossa (original) (raw)

Papers by Cesar Busato

Orientadora : Maria Terezinha Carneiro LeaoDissertaçao (mestrado) - Universidade Federal do Paran... more Orientadora : Maria Terezinha Carneiro LeaoDissertaçao (mestrado) - Universidade Federal do Paraná, Setor de Ciencias da Saúd

Publicatio Uepg: Ciencias Biologicas E Da Saude, 2007

Acta Scientiarum. Health Science, Jan 9, 2012

Pacientes internados em instituições de saúde estão expostos a uma variedade de microorganismos p... more Pacientes internados em instituições de saúde estão expostos a uma variedade de microorganismos patogênicos. Fatores como tempo de permanência, ventilação mecânica e procedimentos invasivos contribuem para o desenvolvimento de infecções hospitalares, necessitando de vigilância permanente por parte das Comissões de Controle de Infecção Hospitalar (CCIH). O objetivo foi traçar perfil das infecções de um hospital de alta complexidade do município de Ponta Grossa, Estado do Paraná, determinando a prevalência de infecção hospitalar nas Unidades de Internação, UTI Adulto e UTI Neonatal; o perfil de sensibilidade aos antimicrobianos. Estudo descritivo, retrospectivo, quantitativo, com 768 infecções tratadas em 2007; 36,8% de origem comunitária; 63,2% hospitalares-16,3% da UTI Neonatal, 27,8% da UTI Adulto e 55,9% das Unidades. As bactérias mais prevalentes nas unidades são: Escherichia coli; Staphylococcus aureus; Pseudomonas aeruginosa. UTI Adulto: Acinetobacter baumannii; Staphylococcus aureus; Escherichia coli. UTI Neonatal: SNPC; Staphylococcus aureus; Klebsiella pneumoniae. Destacamos alta sensibilidade das Acinetobacter baumannii à Ampicilina/Subactam e Tobramicina; eficácia do Meropenem, Ciprofloxaxina e Vancomicina; baixa prevalência de Staphylococcus aureus resistente à Meticilina/MRSA. Estes indicadores apresentaram valores significativos de prevalência e sensibilidade antimicrobiana, resultado dos critérios utilizados pela CCIH da instituição pesquisada-realização de vigilância epidemiológica; Antibiograma Escalonado; monitoramento das prescrições de antimicrobianos; e treinamento dos funcionários. Palavras-chave: prevalência, infecções hospitalares, micro-organismos. Prevalence of hospital infections in a general hospital of high complexity in the Ponta Grossa city in 2007 ABSTRACT. Patients admitted to health institutions are exposed to a variety of pathogenic microorganisms. Factors such as stay time, mechanical ventilation and invasive procedures, contribute for the development of Hospital Infections, requiring constant surveillance from the Hospital Infection Control Committees (HICC). The objective was to outline the profile of infections in a hospital of high complexity, located in the city of Ponta Grossa, Paraná State, determining the prevalence of Hospital Infection in Adult Intensive Care Unit and Neonatal Intensive Care Unit, concerning the profile of sensitivity to antimicrobials. This is a descriptive, retrospective, quantitative study, with 768 infections treated in 2007, 36.8% from Community origin, 63.2% hospital-16.3% from the NICU, 27.8% from adult ICU and 55.9% from Units. The most prevalent bacteria in the units were: Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Adult ICU: Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli. NICU: SNPC, Staphylococcus aureus, Klebsiella pneumoniae. We emphasized the high sensitivity of Acinetobacter baumannii to Ampicillin / sub-activity and Tobramycin; effectiveness of Meropenem, Vancomycin and Ciprofloxacin; low prevalence of methicillin-resistant Staphylococcus aureus/MRSA. These indicators presented significant values of prevalence and antimicrobial sensitivity, resulting from the criteria used by the HICC from the surveyed institution-conducting epidemiological surveillance; Antibiogram Stepped; monitoring of antibiotic prescriptions, and employee training.

Brazilian Journal of Infectious Diseases, May 1, 2014

Introduction: Renal replacement therapy is the treatment of end-stage chronic kidney disease and ... more Introduction: Renal replacement therapy is the treatment of end-stage chronic kidney disease and can be performed through dialysis catheters, arteriovenous fistulas/grafts, and peritoneal dialysis. Patients are usually immunocompromised and exposed to invasive procedures, leading to high rates of infection and increased mortality. Objectives: To compare the prevalence of infection and related deaths, as well as the sensitivity profile of the putative bacteria in patients treated with peritoneal dialysis, arteriovenous fistula hemodialysis and catheter hemodialysis. Methods: This is case-control study. Six hundred forty-four patients undergoing renal replacement therapy were selected. Patients were divided into three groups according to the modality of dialysis treatment: peritoneal dialysis (126 patients), arteriovenous fistula hemodialysis (326 patients), and catheter hemodialysis (192 patients). Results: One hundred sixteen patients (18.01%) developed infection. There was a higher incidence of infection in the peritoneal dialysis group (44 patients; 34.92%; OR: 3.32; CI 95% = 2.13-5.17; p = 0.0001). In the catheter hemodialysis group, 48 patients (25%) had infection (OR: 1.88; CI 95%: 1.24-2.85; p = 0.0035). In the arteriovenous fistula hemodialysis group, 24 patients (7.36%) developed infection (OR: 0.19; CI 95%: 0.12-0.31; p = 0.0001). Five patients (4.31%) died due to infection (four in the peritoneal dialysis group and one in the catheter hemodialysis group). There were no deaths due to infection in the arteriovenous fistula hemodialysis group. Conclusions: Peritoneal dialysis is the treatment with greater risk of infection and mortality, followed by catheter hemodialysis. The lowest risk of infection and mortality was observed in arteriovenous fistula hemodialysis group.

DOAJ (DOAJ: Directory of Open Access Journals), 2012

Tese apresentada ao Programa de Pos-Gradua9ao em Clfnlca CIrlJrglca do Setor de CIE~nClaS da Saud... more Tese apresentada ao Programa de Pos-Gradua9ao em Clfnlca CIrlJrglca do Setor de CIE~nClaS da Saude da Unlversldade Federal do Parana, como requlslto parcial para obte~ao do Grau de Ooutor.

BMC Proceedings, Jun 29, 2011

Ostroski et al.: Antimicrobial use prior as a risk factor for developing extended-spectrum beta-l... more Ostroski et al.: Antimicrobial use prior as a risk factor for developing extended-spectrum beta-lactamse-producing Klebsiella spp. in South Brazil. BMC Proceedings 2011 5(Suppl 6):P138.

Publicatio Uepg: Ciencias Biologicas E Da Saude, 2006

Este trabalho tem por objetivo diagnosticar e padronizar de forma adequada o tratamento tópico da... more Este trabalho tem por objetivo diagnosticar e padronizar de forma adequada o tratamento tópico da úlcera de estase venosa, em todas as suas fases. Com base na metodologia de coleta de dados em forma de questionário, realizado por enfermeira do Programa Saúde da Família em Castro-Paraná, no mês de maio (2004), ficou constatado que não existe um protocolo para tal e muitas vezes há falta de produtos. Porém, isto não impede que o tratamento seja realizado com eficiência utilizando-se o disponível e adquirindo alguns produtos essenciais.

Brazilian Journal of Infectious Diseases, Jun 1, 2006

Objective. Correlate the evolution of the resistance of Staphylococcus aureus collected from heal... more Objective. Correlate the evolution of the resistance of Staphylococcus aureus collected from healthcare workers with the local consumption of antibiotics. Materian and Methods. Open prospective research.Study Site. General Reference Hospital with 200 beds in a 700,000 inhabitant region, in Ponta Grossa, Paraná, Brazil. Results.Two collections (samples) of Staphylococcus aureus isolates were obtained from healthcare-workers during an approximate four-year interval. Samples 1 (n= 200) and 2 (n= 270) had this bacterium in 63 (32%) and 90 (33%) of the patients, respectively. At the same time, the annual consumption of antibiotics in DDD/1,000 patient-days was determined. The variation of resistance was significantly smaller (m.s.d.=12.11) for gentamycin (p<0.01) and (m.s.d.=9.22) for Tobramycin (p<0.05). The correlation between variation in resistance and antibiotic consumption was not significant. Workers studied in the two samples showed a significant (p<0.01) frequency (χ χ χ χ χ 2 =10.44) for persistent nasal carriage and for non carriage. Methicillin resistant Staphylococcus aureus was found in 12 (6%) patients of sample 1 and 11 patients (4%) of sample 2. Conclusions. Stability of resistance allows us to maintain therapeutic outlines. The variation in bacterial resistance in the twice-sampled population (n=105) indicated the selection pressure of the hospital environment. The resistance that was found is representative of the hospital microbiota; this relationship represents a biological model, based on the healthcare-workers' interaction with colonizing bacteria and nosocomial infections. New studies could improve this model for other bacteria, to determine the tendency for resistance and help guide the antibiotic use.

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

- BACKGROUND: Proper fixation of the surgical mesh determines the success of a herniorrhaphy. Und... more - BACKGROUND: Proper fixation of the surgical mesh determines the success of a herniorrhaphy. Understanding the inflammatory response and the mechanical properties of the mesh helps to define whether a fixation method is superior. AIM: This study aimed to evaluate the healing of defects in the abdominal wall of rats, comparing the repair of macroporous polypropylene meshes fixed with surgical glue and polypropylene thread. METHODS: In 20 Wistar rats, a defect was produced in the abdominal wall, with the integrity of the parietal peritoneum. For correction, the meshes were fixed with surgical glue (2-octyl cyanoacrylate) (subgroup C1), or polypropylene suture (subgroup C2). The two subgroups of 10 animals were euthanized on the 90th postoperative day, and the fragments of the abdominal wall were submitted to macroscopic, histological, and tensiometric analysis. RESULTS: Macroscopic analysis did not show any abnormalities. Tensiometry on the 90th postoperative day in subgroup C1 showe...

Brazilian Archives of Biology and Technology, 2020

Cilostazol (CLZ) is a phosphodiesterase III inhibitor with antiplatelet and vasodilator propertie... more Cilostazol (CLZ) is a phosphodiesterase III inhibitor with antiplatelet and vasodilator properties. It has been recently verified that CLZ plays a significant role in the arteries by inhibiting the proliferation and growth of muscle cells, increasing the release of nitric oxide by the endothelium and promoting angiogenesis. Considering these promising effects, the use of nanocapsules may be an interesting strategy to optimize its pharmacokinetics and pharmacodynamics at the vascular level for preventing atherosclerosis. The aim of this study was to evaluate the effect of cilostazol-loaded nanocapsules in the abdominal aortic tunics and on the lipid profile of Wistar rats in order to investigate its potential role in the prevention of atherosclerosis. Thirty-two animals were divided into four groups of eight animals, with 30-day treatment. Group 1 received nanoencapsulated CLZ; Group 2, control nanocapsules with no drug; Group 3, propylene glycol and water; and Group 4, a solution of CLZ in propylene glycol and water. After 30 days, there was no statistically significant difference between the groups regarding the cellularity and thickness of the arterial tunics of the abdominal aorta. However, the group that received nanoencapsulated CLZ (Group 1) had an improvement in HDL-c and triglyceride values compared to unloaded nanocapsules (Group 2).

Publicatio Uepg: Ciencias Biologicas E Da Saude, 2020

Contexto: O tratamento da estenose de carótida visa impedir o aparecimento de possível dano isquê... more Contexto: O tratamento da estenose de carótida visa impedir o aparecimento de possível dano isquêmico encefálico. A cirurgia da estenose carotídea não é isenta de riscos. Objetivos: Avaliar e discutir, em comparação com a literatura, os resultados de pacientes submetidos à cirurgia aberta por estenose de carótidas, em 4 hospitais, de município de médio porte, no estado do Paraná. Método: Estudo retrospectivo, realizado pelo levantamento de 68 prontuários eletrônicos, em 4 hospitais, no período de janeiro de 2014 a julho de 2018. Dados referentes às variáveis idade, sintomatologia, sexo, tempo entre os sintomas e cirurgia, grau de estenose, comorbidades, desfechos e indicação cirúrgica foram comparados com a literatura. Resultados: A idade média foi de 69,3 anos, 60 sintomáticos, 46 masculinos, com média de 70,2 anos e 14 femininos com 66,5 anos; e 8 assintomáticos, 7 masculinos com média de 71,1 anos e uma feminina com 57 anos; 52 foram operados precocemente e 8 após 30 dias. Todos foram submetidos à endarterectomia, com anestesia geral e apenas 2 sem uso de shunt. Complicações maiores em até 30 dias foram apresentadas por 7 pacientes (10,3%), 4 (5,9%) AVE, 1 (1,5%) IAM e 4 (5,9%) foram a óbito, 2 do grupo AVE perioperatório. Conclusão: Os pacientes assintomáticos submetidos ao procedimento não apresentaram complicações perioperatórias maiores. Aqueles com déficits graves e operados tardiamente não se beneficiaram com a cirurgia. Os índices de complicações maiores perioperatórias são semelhantes aos encontrados na literatura nacional e maiores do que em estudos controlados.

Acta Cirurgica Brasileira, 2012

PURPOSE: To evaluate the healing process of a defect in the ventral abdominal wall of rats, compa... more PURPOSE: To evaluate the healing process of a defect in the ventral abdominal wall of rats, comparing the polypropylene and polypropylene/poliglecaprone meshes on the 30th and 60th postoperative day. METHODS: Thirty two Wistar rats were submitted to a ventral abdominal wall defect, with integrity of the parietal peritoneum. In the repair, were used polypropylene (group A) and polypropylene/poliglecaprone (group B) meshes. The groups were subdivided into four subgroups of eight animals euthanized on the 30th (A30 and B30) and 60th postoperative day (A60 and B60). Fragments of the abdominal wall of the animals were submitted to macroscopic, tensiometric and histological evaluations. RESULTS: The tensiometry on subgroup A30 showed a mean average break point of 0.78 MPa and in A60, 0.66 Mpa. In subgroup B30 it was 0.84 MPa and in B60, 1.27 Mpa. The score of the inflammatory process showed subacute phase on A30 and B30 sub-groups and chronic inflammatory process in subgroups A30 and 60B....

Publicatio UEPG: Ciencias Biologicas e da Saude, 2007

medium-sized general hospital Avaliação de tromboprofilaxia em hospital geral de médio porte

Arquivos Brasileiros de Cirurgia Digestiva : ABCD, 2021

Prolene® Ultrapro® Bard Soft®

Jornal Vascular Brasileiro

Resumo A isquemia crítica de membro inferior sem leito distal tem opções restritas para tratament... more Resumo A isquemia crítica de membro inferior sem leito distal tem opções restritas para tratamento. Desviar o fluxo sanguíneo de maneira retrógrada através da circulação venosa é uma alternativa amparada em evidências de inúmeros trabalhos publicados. Comparou-se através de mapeamento dúplex a distribuição do fluxo sanguíneo arterial em membros posteriores de suínos mantidos em circulação fisiológica com o contralateral submetido à isquemia e reperfusão por circulação retrógrada. O fluxo nos membros em circulação fisiológica e retrógrada foi avaliado por mapeamento dúplex através da determinação da velocidade de pico sistólico (VPS), da velocidade diastólica final (VDF) e do índice de resistividade (IR) em artérias selecionadas. A análise comparativa das extremidades mantidas em circulação fisiológica em relação às mantidas em isquemia e reperfusão, por circulação retrógrada, mostrou nestas, ao mapeamento dúplex, que as alterações nos padrões de onda espectral e nas variáveis hemodi...

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

Among the various strategies to avoid exaggerated foreign body reaction in the treatment of herni... more Among the various strategies to avoid exaggerated foreign body reaction in the treatment of hernias is the limitation of the amount of polypropylene or the use of absorbable material. To evaluate the healing of defects in the abdominal wall of rats, comparing microporous polypropylene, macroporous polypropylene and polypropylene/polyglecaprone at the 30º, 60º and 120º postoperative day. Wistar rats were submitted to defect production in the ventral abdominal wall, with integrity of the parietal peritoneum. Prolene®, Ultrapro® and Bard Soft® meshes were used in the correction of the defect. Nine subgroups of 10 animals were submitted to euthanasia at 30th, 60th and 120th postoperative day. Fragments of the abdominal wall of the animals were submitted to tensiometric analysis. The tensiometry at the 30th postoperative day showed greater resistance of the tissues with Bard Soft® (macroporous mesh) in relation to the tissues with Prolene® (microporous mesh). On the 60th postoperative da...