Sujay Bhunia | University of Gour Banga (original) (raw)

Papers by Sujay Bhunia

Indian journal of physiology and pharmacology, 1995

In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulu... more In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulus is altered during acute haemodilution, experiments were conducted in nine anaesthetized, artificially ventilated and thoracotomized cats. Haemodilution was achieved by replacement of blood by the same volume of dextran (MW 150000). Atrial receptor activity, arterial blood pressure, right atrial pressure and ECG were recorded. Heart rate was calculated from ECG records. Arterial blood hematocrit was measured. Mean arterial blood pressure and heart rate were not altered by haemodilution even at a hematocrit level of 12.17 +/- 0.93 percent. Average activity of type-B atrial receptors, mean right atrial pressure, right atrial peak 'v' pressure, right atrial initial 'v' pressure and right atrial 'v' wave amplitude were changed significantly (r < 0.05) during acute haemodilution when the hematocrit was 12.17 +/- 0.93 percent but the atrial type-B receptor activity ...

Indian journal of physiology and pharmacology, 1993

To determine the effects of acute haemodilution on right atrial pressure and right atrial type-A ... more To determine the effects of acute haemodilution on right atrial pressure and right atrial type-A receptor activity, experiments were conducted in nine anaesthetized cats. Haemodilution was induced by replacement of blood by same volume of dextran (molecular weight-150000). Arterial blood pressure, right atrial pressure and right atrial type-A receptor activity were recorded. Hematocrit, arterial blood pO2, pCO2, and pH were measured. Mean arterial blood pressure, pO2, pCO2, and pH were not altered by haemodilution which extended to a hematocrit level of about 13%. Mean right atrial pressure, 'a' wave pressure showed significant changes after 2nd and 3rd exchange. Heart rate and 'a' wave amplitude changed significantly (P < 0.05) after 3rd exchange. The amplitude of the 'a' wave was increased from 3.57 +/- 0.93 to 5.79 +/- 1.46 cm H2O, heart rate was increased from 163.89 +/- 5.36 to 169.22 +/- 4.84 beats/min, mean right atrial pressure was increased from 2...

African Health Sciences

Aim: To study and analyse the socio-demographic profile and basic risk factors of tuberculosis(TB... more Aim: To study and analyse the socio-demographic profile and basic risk factors of tuberculosis(TB) patients and their relationwith the current epidemiological status of TB registered under the RNTEP program in the study area. Subjects and Methods: This prospective study was conducted on 1743 newly registered tuberculosis patients at TB-DOT centerof South 24 Parganas, West Bengal, India from 2011-2014. Socio-demographic variables and baseline characteristics of theparticipants were noted by a semi-structured questionnaire. Results: Our study results indicate that more than 95% of the TB patients were from lower socioeconomic class, and hadpoor literacy status and tuberculosis was observed highest in non-agricultural labour and cultivators. Among the young adult’smajority of the affected population were females from the lower/upper-lower socioeconomic class. Our analysis revealed that,in successful tuberculosis therapy, men were more defaulters than women. Conclusion: Our study provid...

Journal of thermal biology, 2018

Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect f... more Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect from oxidative stress induced damages by heat stress has been investigated in this study. Heat stress was induced maintaining body and testicular temperature at 43°C for 30min/day for 15 days using a hyperthermia induction chamber. Four groups of rats (n=6 per group) comprising of Group-I (control) -kept at 32°C, Group-II -exposed to heat stress alone, Group-III received RGJ (0.8ml/rat/day) alone and Group-IV -exposed to heat stress and received RGJ at same dose. Analysis of blood and testicular tissue exhibited significant reduction in serum testosterone, testicular superoxide dismutase, testicular catalase and testicular glutathione (all p < 0.001); whereas, significant rise in the level of serum corticosteroid, testicular lipid peroxidase and the apoptotic enzyme caspase-3 of testis (all p < 0.001) were observed along with substantial increase in testicular Hsp72 and Hsf-1, and d...

Journal of Tropical Diseases, 2016

The drug resistant clinical isolate of Mtb was obtained from Department of Laboratory Medicine (M... more The drug resistant clinical isolate of Mtb was obtained from Department of Laboratory Medicine (Microbiology Division) of (AMRI) hospital, Kolkata. 4 ml of BBL Middlebrook 7H9 Broth was added to a 16.5 x 128 mm capped sterile tube, containing 8-10 glass beads. Many colonies, not more than 14 days old, were then scrapped from the MDR growth slant (Löwenstein-Jensen media) with a sterile

Asian Pacific Journal of Tropical Disease, 2015

Bioinformation, 2016

A 6.76 kDa molecular weight cardio and cytotoxic protein of 60 amino acids in length called NK-CT... more A 6.76 kDa molecular weight cardio and cytotoxic protein of 60 amino acids in length called NK-CT1, was purified from the venom of Indian monocellate cobra (Naja kaouthia) by ion-exchange chromatography and HPLC as described in our earlier report. Therefore it is of interest to utlize the sequence of NK-CT1 for further functional inference using molecular modeling and docking. Thus homology model of NK-CT1 is described in this report. The anti-proliferative activity of the protein, binding with human DNA topoisomerase-II alpha was demonstrated using docking data with AUTODOCK and AUTODOCK MGL tools. Data shows that M26, V27 and S28 of NK-CT1 is in close contact with the nucleotides of the oligonucleotide, bound with topoisomerase-II alpha complex.

Chemischer Informationsdienst, 1973

Asian Pacific Journal of Tropical Disease, 2015

Journal of Thermal Biology (Elsevier), 2018

Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect f... more Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect from oxidative stress induced damages by heat stress has been investigated in this study. Heat stress was induced maintaining body and testicular temperature at 43 °C for 30 min/day for 15 days using a hyperthermia induction chamber. Four groups of rats (n=6 per group) comprising of Group-I (control) –kept at 32 °C, Group-II –exposed to heat stress alone, Group-III received RGJ (0.8 ml/rat/day) alone and Group-IV –exposed to heat stress and received RGJ at same dose. Analysis of blood and testicular tissue exhibited significant reduction in serum testosterone, testicular superoxide dismutase, testicular catalase and testicular glutathione (all p < 0.001); whereas, significant rise in the level of serum corticosteroid, testicular lipid peroxidase and the apoptotic enzyme caspase-3 of testis (all p < 0.001) were observed along with substantial increase in testicular Hsp72 and Hsf-1, a...

Indian journal of physiology and pharmacology, 1995

In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulu... more In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulus is altered during acute haemodilution, experiments were conducted in nine anaesthetized, artificially ventilated and thoracotomized cats. Haemodilution was achieved by replacement of blood by the same volume of dextran (MW 150000). Atrial receptor activity, arterial blood pressure, right atrial pressure and ECG were recorded. Heart rate was calculated from ECG records. Arterial blood hematocrit was measured. Mean arterial blood pressure and heart rate were not altered by haemodilution even at a hematocrit level of 12.17 +/- 0.93 percent. Average activity of type-B atrial receptors, mean right atrial pressure, right atrial peak 'v' pressure, right atrial initial 'v' pressure and right atrial 'v' wave amplitude were changed significantly (r < 0.05) during acute haemodilution when the hematocrit was 12.17 +/- 0.93 percent but the atrial type-B receptor activity ...

Indian journal of physiology and pharmacology, 1993

To determine the effects of acute haemodilution on right atrial pressure and right atrial type-A ... more To determine the effects of acute haemodilution on right atrial pressure and right atrial type-A receptor activity, experiments were conducted in nine anaesthetized cats. Haemodilution was induced by replacement of blood by same volume of dextran (molecular weight-150000). Arterial blood pressure, right atrial pressure and right atrial type-A receptor activity were recorded. Hematocrit, arterial blood pO2, pCO2, and pH were measured. Mean arterial blood pressure, pO2, pCO2, and pH were not altered by haemodilution which extended to a hematocrit level of about 13%. Mean right atrial pressure, 'a' wave pressure showed significant changes after 2nd and 3rd exchange. Heart rate and 'a' wave amplitude changed significantly (P < 0.05) after 3rd exchange. The amplitude of the 'a' wave was increased from 3.57 +/- 0.93 to 5.79 +/- 1.46 cm H2O, heart rate was increased from 163.89 +/- 5.36 to 169.22 +/- 4.84 beats/min, mean right atrial pressure was increased from 2...

African Health Sciences

Aim: To study and analyse the socio-demographic profile and basic risk factors of tuberculosis(TB... more Aim: To study and analyse the socio-demographic profile and basic risk factors of tuberculosis(TB) patients and their relationwith the current epidemiological status of TB registered under the RNTEP program in the study area. Subjects and Methods: This prospective study was conducted on 1743 newly registered tuberculosis patients at TB-DOT centerof South 24 Parganas, West Bengal, India from 2011-2014. Socio-demographic variables and baseline characteristics of theparticipants were noted by a semi-structured questionnaire. Results: Our study results indicate that more than 95% of the TB patients were from lower socioeconomic class, and hadpoor literacy status and tuberculosis was observed highest in non-agricultural labour and cultivators. Among the young adult’smajority of the affected population were females from the lower/upper-lower socioeconomic class. Our analysis revealed that,in successful tuberculosis therapy, men were more defaulters than women. Conclusion: Our study provid...

Journal of thermal biology, 2018

Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect f... more Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect from oxidative stress induced damages by heat stress has been investigated in this study. Heat stress was induced maintaining body and testicular temperature at 43°C for 30min/day for 15 days using a hyperthermia induction chamber. Four groups of rats (n=6 per group) comprising of Group-I (control) -kept at 32°C, Group-II -exposed to heat stress alone, Group-III received RGJ (0.8ml/rat/day) alone and Group-IV -exposed to heat stress and received RGJ at same dose. Analysis of blood and testicular tissue exhibited significant reduction in serum testosterone, testicular superoxide dismutase, testicular catalase and testicular glutathione (all p < 0.001); whereas, significant rise in the level of serum corticosteroid, testicular lipid peroxidase and the apoptotic enzyme caspase-3 of testis (all p < 0.001) were observed along with substantial increase in testicular Hsp72 and Hsf-1, and d...

Journal of Tropical Diseases, 2016

The drug resistant clinical isolate of Mtb was obtained from Department of Laboratory Medicine (M... more The drug resistant clinical isolate of Mtb was obtained from Department of Laboratory Medicine (Microbiology Division) of (AMRI) hospital, Kolkata. 4 ml of BBL Middlebrook 7H9 Broth was added to a 16.5 x 128 mm capped sterile tube, containing 8-10 glass beads. Many colonies, not more than 14 days old, were then scrapped from the MDR growth slant (Löwenstein-Jensen media) with a sterile

Asian Pacific Journal of Tropical Disease, 2015

Bioinformation, 2016

A 6.76 kDa molecular weight cardio and cytotoxic protein of 60 amino acids in length called NK-CT... more A 6.76 kDa molecular weight cardio and cytotoxic protein of 60 amino acids in length called NK-CT1, was purified from the venom of Indian monocellate cobra (Naja kaouthia) by ion-exchange chromatography and HPLC as described in our earlier report. Therefore it is of interest to utlize the sequence of NK-CT1 for further functional inference using molecular modeling and docking. Thus homology model of NK-CT1 is described in this report. The anti-proliferative activity of the protein, binding with human DNA topoisomerase-II alpha was demonstrated using docking data with AUTODOCK and AUTODOCK MGL tools. Data shows that M26, V27 and S28 of NK-CT1 is in close contact with the nucleotides of the oligonucleotide, bound with topoisomerase-II alpha complex.

Chemischer Informationsdienst, 1973

Asian Pacific Journal of Tropical Disease, 2015

Journal of Thermal Biology (Elsevier), 2018

Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect f... more Ability of red grape juice (RGJ), a known antioxidant, on testis of adult Wister rat to protect from oxidative stress induced damages by heat stress has been investigated in this study. Heat stress was induced maintaining body and testicular temperature at 43 °C for 30 min/day for 15 days using a hyperthermia induction chamber. Four groups of rats (n=6 per group) comprising of Group-I (control) –kept at 32 °C, Group-II –exposed to heat stress alone, Group-III received RGJ (0.8 ml/rat/day) alone and Group-IV –exposed to heat stress and received RGJ at same dose. Analysis of blood and testicular tissue exhibited significant reduction in serum testosterone, testicular superoxide dismutase, testicular catalase and testicular glutathione (all p < 0.001); whereas, significant rise in the level of serum corticosteroid, testicular lipid peroxidase and the apoptotic enzyme caspase-3 of testis (all p < 0.001) were observed along with substantial increase in testicular Hsp72 and Hsf-1, a...