Mirko Spiroski | Ss. Cyril and Methodius University (UKIM) (Univerzitet "Sv. Kiril i Metodij" - Skopje) (original) (raw)

Papers by Mirko Spiroski

Research paper thumbnail of Killer Cell Immunoglobulin-Like Receptor Genes Polymorphisms in Macedonian Patients with Haematological Malignancies

Macedonian Journal of Medical Sciences, Mar 15, 2013

The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes (KIR2DL1,

Research paper thumbnail of Immunoglobulin Classes and Subclasses in Macedonian Elderly People Maced

Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylo... more Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylosing spondylitis in patients from the Republic of Macedonia. Material and Methods: This study included 307 subjects (250 healthy individuals and 57 patients with ankylosing spondylitis who were diagnosed at the University Clinic of Rheumatology in Skopje). The HLA typing of class 1 (HLA-A, HLA-C and HLA-B) genes was performed using the method of Reverse Line Strip, after isolation of DNK from the blood leucocytes with the standard phenol-chloroforme method. The HLA sub typing of HLA-B*27 was performed with high resolution single-strand polymorphism.

Research paper thumbnail of The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP - 2018), Sarajevo, December 8th, 2018

Acta Informatica Medica, 2018

Introduction: The PhD program represents the biggest step in the education and the PhD itself is ... more Introduction: The PhD program represents the biggest step in the education and the PhD itself is the crown of the work of one scientist (1). Each PhD thesis represents the contribution of the author to the development of the area in which he/she is active, and must present something new, unknown or unsufficiently explored until then, with direct implication for the practice. Aim: To present the difference between PhD program during 50 years period, with the presentation of the advantages that development and availability of science brought. Results: When different literature was not available in digital form, writing a PhD thesis after a postgraduate study and a long-term specialist work was the crown of the work of medical professional. Unfortunately, this process was sometimes difficult and was dependent on many parameters and subjective opinions, and was subject of numerous manipulations. In the present age, following the reform of education, and the implementation of Bologna Education System, the number of PhD students has increased and the study started to be held at all Universities in Bosnia and Herzegovina (2). All those who completed the six-year study are able to attend the PhD studies. The main obligation for student and requirement for obtaining PhD degree is article from PhD thesis published in the Current Contents database. This criterion was removed over time and the situation now is that obligation is article that is published in journal thatis in the reference database (without clear definition in which databases). Quantity is achieved but we cannot say that for quality. During the year 2017, in Bosnia and Herzegovina, 11 original articles in the field of clinical medicine were published (indexed in the journals that are in the Current Contents Indexed Publications (journals that belong to CC, SCI and SCI-E base) (3,4). These 11 papers are from the field of gastroenterology, psychiatry and ophthalmology (2,3). If this is the scientific opus of already experienced scientist, the question remains what is expected from young researchers. Conclusion: Which system is better, on this question answer cannot be given, because both systems have shortcommings and advantages. The fact is that there is a gap between generations, which is unlikely to be resolved. It is also a fact that the Bologna system is not ideal, but it is currently our present (5, 6,7). A lot of students are enrolled, and the system must help them, in the process of successfully completing their PhD programs. This help cannot be achieved through the lowering of criteria (publications in science remain the only weapon in evaluation). This step leads to decreasing of quality. Quality is what needs to be taught, quality is the only one that science needs. The results in 2017 for Bosnia and Herzegovina and even the worst experience in the past few years is the red alert and only together, both professors and students, can find a way out of one of the most difficult situations.

Research paper thumbnail of Paper: CYTOKINE GENE POLYMORPHISMS IN POPULATION OF ETHNIC MACEDONIANS

Research paper thumbnail of Basic Science Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically Ill Macedonian Patients

Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathol... more Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.

Research paper thumbnail of Basic Science Republic of Macedonia

Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes an... more Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes and KIR genotypes in Macedonian patients with transplanted bone marrow and their sibling donors in treatment of haematological malignancy, and to analyse eventual association of the gene content with the occurrence of a graft versus host disease (GVHD). Material and Methods: The study was performed on 24 patients and their HLA-matched sibling donors. Results: Comparison of KIR gene frequencies between the total 24 donors and healthy Macedonians reveals statistically significant difference for KIR2DS1 (F= 0.481 in the controls group, and 0.76 in the patients group, p=0.004). This significance is even higher when the frequency of KIR2DS1 in controls is compared with the frequency in donors from pairs with GVHD (F= 0.923, P= 0.002). Another significant difference was observed for the frequency of the full-length allele of KIR2DS4*001-002, present in 25.2% of the control individuals, but in as...

Research paper thumbnail of 1 University Children Hospital Skopje, Republic of Macedonia

Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cy... more Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals.

Research paper thumbnail of Paper: FACTOR V LEIDEN IS ASSOCIATED WITH HIGHER RISK OF DEEP VENOUS THROMBOSIS OF LARGE BLOOD VESSELS

Research paper thumbnail of Abstract: P1169 HOMOCYSTEINE, MTHFR POLYMORFISMS AND ARTERIAL OCCLUSIVE DISEASE

Atherosclerosis Supplements, 2009

To determine total homocysteine (tHcy) in healthy subjects and in patients with arterial occlusiv... more To determine total homocysteine (tHcy) in healthy subjects and in patients with arterial occlusive disease (AOD), the prevalence of C677T gen mutation of the methylentetrahydrofolate reductase (MTHFR) and to examined the correlation between C677T genotype and homocysteine.

Research paper thumbnail of The level of carcinoembryonic antigen, tissue proliferative antigen and carbonhydratic antigen 19.9 in serum of patients with different hystological types of lung cancer

Research paper thumbnail of Neuron specific enolases: diagnostic marker for small cell lung cancer

Research paper thumbnail of IL10-819 and IL10-592 polymorphisms are associated with chronic periodontitis in a Macedonian population. Hum Immunol. 2012 Jul; 73 (7): 753

Research paper thumbnail of Macedonian Medical Master of Science Theses in Public Health Defended in 2007-2010

Macedonian Journal of Medical Sciences, 2012

Research paper thumbnail of Retraction: Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): Toward Zero Error. Open Access Maced J Med Sci. 2020 May 28; 8(F):52-57. https://doi.org/10.3889/oamjms.2020.3791

Open Access Macedonian Journal of Medical Sciences

Editor-in-Chief has retracted the article Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): To... more Editor-in-Chief has retracted the article Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): Toward Zero Error. Open Access Maced J Med Sci. 2020 May 28; 8(F):52-57. We received a copy of the letter from Dr Vishal Gupta, MS, MCh, FACS and Dr Gaurav Jain sent to Dr Coco. They draw our attention to the fact that this article has taken most of its material from their review article. We contacted corresponding author and he agreed to retract the published paper. As such, we retract the article from the literature and by guidelines and best editorial practices from the Committee on Publication Ethics. We apologize to our audience about this unfortunate situation.

Research paper thumbnail of Recruitment of Marrow Donors in the Non-governmental Sector of the Republic of North Macedonia, 2022

South East European Journal of Immunology

BACKGROUND: Bone marrow transplantation is a well-established lifesaving treatment procedure for ... more BACKGROUND: Bone marrow transplantation is a well-established lifesaving treatment procedure for many patients with various diseases, such as blood cell cancers (leukemia), some severe hematological diseases (aplastic anemia) and some rare diseases, as well as immune deficiency disorders. Allogeneic hematopoietic stem cell transplantation (HSCT) represents a potentially curative therapy for various hematologic disorders and even the only curative treatment for some diseases (e.g., myelodysplastic syndromes). As an alternative donor strategy, in patients lacking a human leukocyte antigen-matched donor or haploidentical donor, mismatched unrelated donors offer the option of using HSCT in this group of patients. Since the establishment of the first registry in the world for recruitment of unrelated bone marrow donors, the number of newly formed registries has increased over the years. In our country, in addition to the government-funded registry, housed at the Institute of Immunobiolog...

Research paper thumbnail of Retraction: Five papers from Open Access Maced J Med Sci. Vol. 7 No. 18 (2019): Sep 30 (Global Dermatology)

Open Access Macedonian Journal of Medical Sciences, 2020

Editor-in-Chief has retracted the following articles from the special issue Vol. 7 No. 18 (2019):... more Editor-in-Chief has retracted the following articles from the special issue Vol. 7 No. 18 (2019): Sep 30 (Global Dermatology): (1) DNA Waves and Their Applications in Biology - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.767; (2) Recovery of Brain in Chick Embryos by Growing Second Heart and Brain - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.777; (3) A Mathematical Model for the Signal of Death and Emergence of Mind Out of Brain in Izhikevich Neuron Model - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.774; (4) A Black Hole at the Center of Earth Plays the Role of the Biggest System of Telecommunication for Connecting DNAs, Dark DNAs and Molecules of Water on 4+N- Dimensional Manifold - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10...

Research paper thumbnail of A Flexible Skewed Link Model for Ordinal Outcomes: An Application to Infertility

Open Access Macedonian Journal of Medical Sciences, 2020

BACKGROUND: An important issue in modeling categorical response data is the choice of the links. ... more BACKGROUND: An important issue in modeling categorical response data is the choice of the links. The commonly used complementary log-log link is inclined to link misspecification due to its positive and fixed skewness parameter. AIM: The objective of this paper is to introduce a flexible skewed link function for modeling ordinal data with some covariates. METHODS: We introduce a flexible skewed link model for the cumulative ordinal regression model based on Chen model. RESULTS: The main advantage suggested by the proposed links is the skewed link provide much more identifiable than the existing skewed links. The propriety of posterior distributions under proper and improper priors is explored in detail. An efficient Markov chain Monte Carlo algorithm is developed for sampling from the posterior distribution. CONCLUSION: The proposed methodology is motivated and illustrated by ovary hyperstimulation syndrome data.

Research paper thumbnail of Retraction: Singhal R, Rai B. sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease. Open Access Maced J Med Sci. 2017; 5(1):68-1 and Rai B, Kaur J, Jain R. Salivary and serum 8-hydroxydeoxyguanosine level in simulated microgravity. Maced J

Open Access Macedonian Journal of Medical Sciences, 2019

Editor-in-Chief has retracted the articles "sTNF-R Levels: Apical Periodontitis Linked to Co... more Editor-in-Chief has retracted the articles "sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease." published by Singhal R & Rai B and "Salivary and serum 8-hydroxydeoxyguanosine level in simulated microgravity." published by Rai B, Kaur J, Jain R. An internal investigation has raised sufficient evidence of the inconsistent results and high similarity index. As such, we retract these two articles from the literature and by guidelines and best editorial practices from the Committee on Publication Ethics. We apologise to our audience about this unfortunate situation.

Research paper thumbnail of Relative Citation Ratio of Top Twenty Macedonian Biomedical Scientists in PubMed: A New Metric that Uses Citation Rates to Measure Influence at the Article Level

Open access Macedonian journal of medical sciences, Jan 15, 2016

The aim of this study was to analyze relative citation ratio (RCR) of top twenty Macedonian biome... more The aim of this study was to analyze relative citation ratio (RCR) of top twenty Macedonian biomedical scientists with a new metric that uses citation rates to measure influence at the article level. Top twenty Macedonian biomedical scientists were identified by GoPubMed on the base of the number of deposited abstracts in PubMed, corrected with the data from previously published paper, and completed with the Macedonian biomedical scientists working in countries outside the Republic of Macedonia, but born or previously worked in the country. iCite was used as a tool to access a dashboard of bibliometrics for papers associated with a portfolio. The biggest number of top twenty Macedonian biomedical scientists has RCR lower than one. Only four Macedonian biomedical scientists have bigger RCR in comparison with those in PubMed. The most prominent RCR of 2.29 has Rosoklija G. RCR of the most influenced individual papers deposited in PubMed has shown the biggest value for the paper of Efr...

Research paper thumbnail of How to Verify Plagiarism of the Paper Written in Macedonian and Translated in Foreign Language?

Open Access Macedonian Journal of Medical Sciences, 2016

AIM: The aim of this study was to show how to verify plagiarism of the paper written in Macedonia... more AIM: The aim of this study was to show how to verify plagiarism of the paper written in Macedonian and translated in foreign language.MATERIAL AND METHODS: Original article “Ethics in Medical Research Involving Human Subjects”, written in Macedonian, was submitted as an assay-2 for the subject Ethics and published by Ilina Stefanovska, PhD candidate from the Iustinianus Primus Faculty of Law, Ss Cyril and Methodius University of Skopje (UKIM), Skopje, Republic of Macedonia in Fabruary, 2013. Suspected article for plagiarism was published by Prof. Dr. Gordana Panova from the Faculty of Medical Sciences, University Goce Delchev, Shtip, Republic of Macedonia in English with the identical title and identical content in International scientific on-line journal "SCIENCE & TECHNOLOGIES", Publisher "Union of Scientists - Stara Zagora".RESULTS: Original document (written in Macedonian) was translated with Google Translator; suspected article (published in English pdf file...

Research paper thumbnail of Killer Cell Immunoglobulin-Like Receptor Genes Polymorphisms in Macedonian Patients with Haematological Malignancies

Macedonian Journal of Medical Sciences, Mar 15, 2013

The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes (KIR2DL1,

Research paper thumbnail of Immunoglobulin Classes and Subclasses in Macedonian Elderly People Maced

Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylo... more Aim: The aim of this study was to determine the association of HLA-A, -C and -B genes with ankylosing spondylitis in patients from the Republic of Macedonia. Material and Methods: This study included 307 subjects (250 healthy individuals and 57 patients with ankylosing spondylitis who were diagnosed at the University Clinic of Rheumatology in Skopje). The HLA typing of class 1 (HLA-A, HLA-C and HLA-B) genes was performed using the method of Reverse Line Strip, after isolation of DNK from the blood leucocytes with the standard phenol-chloroforme method. The HLA sub typing of HLA-B*27 was performed with high resolution single-strand polymorphism.

Research paper thumbnail of The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP - 2018), Sarajevo, December 8th, 2018

Acta Informatica Medica, 2018

Introduction: The PhD program represents the biggest step in the education and the PhD itself is ... more Introduction: The PhD program represents the biggest step in the education and the PhD itself is the crown of the work of one scientist (1). Each PhD thesis represents the contribution of the author to the development of the area in which he/she is active, and must present something new, unknown or unsufficiently explored until then, with direct implication for the practice. Aim: To present the difference between PhD program during 50 years period, with the presentation of the advantages that development and availability of science brought. Results: When different literature was not available in digital form, writing a PhD thesis after a postgraduate study and a long-term specialist work was the crown of the work of medical professional. Unfortunately, this process was sometimes difficult and was dependent on many parameters and subjective opinions, and was subject of numerous manipulations. In the present age, following the reform of education, and the implementation of Bologna Education System, the number of PhD students has increased and the study started to be held at all Universities in Bosnia and Herzegovina (2). All those who completed the six-year study are able to attend the PhD studies. The main obligation for student and requirement for obtaining PhD degree is article from PhD thesis published in the Current Contents database. This criterion was removed over time and the situation now is that obligation is article that is published in journal thatis in the reference database (without clear definition in which databases). Quantity is achieved but we cannot say that for quality. During the year 2017, in Bosnia and Herzegovina, 11 original articles in the field of clinical medicine were published (indexed in the journals that are in the Current Contents Indexed Publications (journals that belong to CC, SCI and SCI-E base) (3,4). These 11 papers are from the field of gastroenterology, psychiatry and ophthalmology (2,3). If this is the scientific opus of already experienced scientist, the question remains what is expected from young researchers. Conclusion: Which system is better, on this question answer cannot be given, because both systems have shortcommings and advantages. The fact is that there is a gap between generations, which is unlikely to be resolved. It is also a fact that the Bologna system is not ideal, but it is currently our present (5, 6,7). A lot of students are enrolled, and the system must help them, in the process of successfully completing their PhD programs. This help cannot be achieved through the lowering of criteria (publications in science remain the only weapon in evaluation). This step leads to decreasing of quality. Quality is what needs to be taught, quality is the only one that science needs. The results in 2017 for Bosnia and Herzegovina and even the worst experience in the past few years is the red alert and only together, both professors and students, can find a way out of one of the most difficult situations.

Research paper thumbnail of Paper: CYTOKINE GENE POLYMORPHISMS IN POPULATION OF ETHNIC MACEDONIANS

Research paper thumbnail of Basic Science Association of Killer Cell Immunoglobulin-Like Receptor Genes with Pandemic Influenza A (H1N1)pdm09 Infection in Critically Ill Macedonian Patients

Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathol... more Background: Infection by the pandemic influenza A (H1N1)pdm09 virus results in significant pathology disease in many cases in different populations worldwide. The natural killer (NK) cells are among the major effectors important in early innate immune responses to viral infections, interacting with host cells through their activating or inhibiting receptors. Aim: The aim of this study was to analyze Killer Ig-Like Receptor (KIR) gene polymorphisms in critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. Material and Methods: The studied sample consists of 63 critically ill Macedonian patients with pandemic influenza A (H1N1)pdm09 infection. The population genetics analysis package, Arlequin, was used for analysis of the data. Results: We found that all 16 KIR genes were observed in the studied individuals and framework genes (KIR3DL3, KIR3DP1, KIR2DL4, and KIR3DL2) were present in all individuals. The results of tested linkage disequilibrium (LD) among KIR genes demonstrated that KIR genes present a wide range of linkage disequilibrium. Comparison of KIR gene frequencies between critically ill H1N1/09 Macedonian patients and healthy subjects reveals statistically significant difference for frequency of KIR2DL1 (F=1 in the patients group, and 0.94 in the control group, p=0.045). Conclusion: We did not found any significant association of all 16 KIR genes or KIR genotypes with critically ill (H1N1)pdm09 Macedonian patients, except for the KIR2DL1.

Research paper thumbnail of Basic Science Republic of Macedonia

Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes an... more Aim: The aim of this study was to examine the gene frequencies of 16 KIR genes and pseudogenes and KIR genotypes in Macedonian patients with transplanted bone marrow and their sibling donors in treatment of haematological malignancy, and to analyse eventual association of the gene content with the occurrence of a graft versus host disease (GVHD). Material and Methods: The study was performed on 24 patients and their HLA-matched sibling donors. Results: Comparison of KIR gene frequencies between the total 24 donors and healthy Macedonians reveals statistically significant difference for KIR2DS1 (F= 0.481 in the controls group, and 0.76 in the patients group, p=0.004). This significance is even higher when the frequency of KIR2DS1 in controls is compared with the frequency in donors from pairs with GVHD (F= 0.923, P= 0.002). Another significant difference was observed for the frequency of the full-length allele of KIR2DS4*001-002, present in 25.2% of the control individuals, but in as...

Research paper thumbnail of 1 University Children Hospital Skopje, Republic of Macedonia

Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cy... more Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of T-helper 2 cells. The aim if this study was to determine whether cytokine gene polymorphisms might influence the development of AD. Single nucleotide polymorphisms in the genes for I-L1alpha, IL-1beta, IL-1R, IL-2, IL-4, IL-6, IL-10, IL-12, TGF beta, TNF and IFNgamma were investigated by PCR and sequence specific primers in Macedonian patients with AD (67 children, age of 6 months to 5 years) and 301 normal unrelated individuals.

Research paper thumbnail of Paper: FACTOR V LEIDEN IS ASSOCIATED WITH HIGHER RISK OF DEEP VENOUS THROMBOSIS OF LARGE BLOOD VESSELS

Research paper thumbnail of Abstract: P1169 HOMOCYSTEINE, MTHFR POLYMORFISMS AND ARTERIAL OCCLUSIVE DISEASE

Atherosclerosis Supplements, 2009

To determine total homocysteine (tHcy) in healthy subjects and in patients with arterial occlusiv... more To determine total homocysteine (tHcy) in healthy subjects and in patients with arterial occlusive disease (AOD), the prevalence of C677T gen mutation of the methylentetrahydrofolate reductase (MTHFR) and to examined the correlation between C677T genotype and homocysteine.

Research paper thumbnail of The level of carcinoembryonic antigen, tissue proliferative antigen and carbonhydratic antigen 19.9 in serum of patients with different hystological types of lung cancer

Research paper thumbnail of Neuron specific enolases: diagnostic marker for small cell lung cancer

Research paper thumbnail of IL10-819 and IL10-592 polymorphisms are associated with chronic periodontitis in a Macedonian population. Hum Immunol. 2012 Jul; 73 (7): 753

Research paper thumbnail of Macedonian Medical Master of Science Theses in Public Health Defended in 2007-2010

Macedonian Journal of Medical Sciences, 2012

Research paper thumbnail of Retraction: Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): Toward Zero Error. Open Access Maced J Med Sci. 2020 May 28; 8(F):52-57. https://doi.org/10.3889/oamjms.2020.3791

Open Access Macedonian Journal of Medical Sciences

Editor-in-Chief has retracted the article Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): To... more Editor-in-Chief has retracted the article Coco D, Leanza S. Laparoscopic Cholecystectomy (LC): Toward Zero Error. Open Access Maced J Med Sci. 2020 May 28; 8(F):52-57. We received a copy of the letter from Dr Vishal Gupta, MS, MCh, FACS and Dr Gaurav Jain sent to Dr Coco. They draw our attention to the fact that this article has taken most of its material from their review article. We contacted corresponding author and he agreed to retract the published paper. As such, we retract the article from the literature and by guidelines and best editorial practices from the Committee on Publication Ethics. We apologize to our audience about this unfortunate situation.

Research paper thumbnail of Recruitment of Marrow Donors in the Non-governmental Sector of the Republic of North Macedonia, 2022

South East European Journal of Immunology

BACKGROUND: Bone marrow transplantation is a well-established lifesaving treatment procedure for ... more BACKGROUND: Bone marrow transplantation is a well-established lifesaving treatment procedure for many patients with various diseases, such as blood cell cancers (leukemia), some severe hematological diseases (aplastic anemia) and some rare diseases, as well as immune deficiency disorders. Allogeneic hematopoietic stem cell transplantation (HSCT) represents a potentially curative therapy for various hematologic disorders and even the only curative treatment for some diseases (e.g., myelodysplastic syndromes). As an alternative donor strategy, in patients lacking a human leukocyte antigen-matched donor or haploidentical donor, mismatched unrelated donors offer the option of using HSCT in this group of patients. Since the establishment of the first registry in the world for recruitment of unrelated bone marrow donors, the number of newly formed registries has increased over the years. In our country, in addition to the government-funded registry, housed at the Institute of Immunobiolog...

Research paper thumbnail of Retraction: Five papers from Open Access Maced J Med Sci. Vol. 7 No. 18 (2019): Sep 30 (Global Dermatology)

Open Access Macedonian Journal of Medical Sciences, 2020

Editor-in-Chief has retracted the following articles from the special issue Vol. 7 No. 18 (2019):... more Editor-in-Chief has retracted the following articles from the special issue Vol. 7 No. 18 (2019): Sep 30 (Global Dermatology): (1) DNA Waves and Their Applications in Biology - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.767; (2) Recovery of Brain in Chick Embryos by Growing Second Heart and Brain - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.777; (3) A Mathematical Model for the Signal of Death and Emergence of Mind Out of Brain in Izhikevich Neuron Model - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10.3889/oamjms.2019.774; (4) A Black Hole at the Center of Earth Plays the Role of the Biggest System of Telecommunication for Connecting DNAs, Dark DNAs and Molecules of Water on 4+N- Dimensional Manifold - Massimo Fioranelli et al. - Open Access Macedonian Journal of Medical Sciences (2019) - DOI: 10...

Research paper thumbnail of A Flexible Skewed Link Model for Ordinal Outcomes: An Application to Infertility

Open Access Macedonian Journal of Medical Sciences, 2020

BACKGROUND: An important issue in modeling categorical response data is the choice of the links. ... more BACKGROUND: An important issue in modeling categorical response data is the choice of the links. The commonly used complementary log-log link is inclined to link misspecification due to its positive and fixed skewness parameter. AIM: The objective of this paper is to introduce a flexible skewed link function for modeling ordinal data with some covariates. METHODS: We introduce a flexible skewed link model for the cumulative ordinal regression model based on Chen model. RESULTS: The main advantage suggested by the proposed links is the skewed link provide much more identifiable than the existing skewed links. The propriety of posterior distributions under proper and improper priors is explored in detail. An efficient Markov chain Monte Carlo algorithm is developed for sampling from the posterior distribution. CONCLUSION: The proposed methodology is motivated and illustrated by ovary hyperstimulation syndrome data.

Research paper thumbnail of Retraction: Singhal R, Rai B. sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease. Open Access Maced J Med Sci. 2017; 5(1):68-1 and Rai B, Kaur J, Jain R. Salivary and serum 8-hydroxydeoxyguanosine level in simulated microgravity. Maced J

Open Access Macedonian Journal of Medical Sciences, 2019

Editor-in-Chief has retracted the articles "sTNF-R Levels: Apical Periodontitis Linked to Co... more Editor-in-Chief has retracted the articles "sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease." published by Singhal R & Rai B and "Salivary and serum 8-hydroxydeoxyguanosine level in simulated microgravity." published by Rai B, Kaur J, Jain R. An internal investigation has raised sufficient evidence of the inconsistent results and high similarity index. As such, we retract these two articles from the literature and by guidelines and best editorial practices from the Committee on Publication Ethics. We apologise to our audience about this unfortunate situation.

Research paper thumbnail of Relative Citation Ratio of Top Twenty Macedonian Biomedical Scientists in PubMed: A New Metric that Uses Citation Rates to Measure Influence at the Article Level

Open access Macedonian journal of medical sciences, Jan 15, 2016

The aim of this study was to analyze relative citation ratio (RCR) of top twenty Macedonian biome... more The aim of this study was to analyze relative citation ratio (RCR) of top twenty Macedonian biomedical scientists with a new metric that uses citation rates to measure influence at the article level. Top twenty Macedonian biomedical scientists were identified by GoPubMed on the base of the number of deposited abstracts in PubMed, corrected with the data from previously published paper, and completed with the Macedonian biomedical scientists working in countries outside the Republic of Macedonia, but born or previously worked in the country. iCite was used as a tool to access a dashboard of bibliometrics for papers associated with a portfolio. The biggest number of top twenty Macedonian biomedical scientists has RCR lower than one. Only four Macedonian biomedical scientists have bigger RCR in comparison with those in PubMed. The most prominent RCR of 2.29 has Rosoklija G. RCR of the most influenced individual papers deposited in PubMed has shown the biggest value for the paper of Efr...

Research paper thumbnail of How to Verify Plagiarism of the Paper Written in Macedonian and Translated in Foreign Language?

Open Access Macedonian Journal of Medical Sciences, 2016

AIM: The aim of this study was to show how to verify plagiarism of the paper written in Macedonia... more AIM: The aim of this study was to show how to verify plagiarism of the paper written in Macedonian and translated in foreign language.MATERIAL AND METHODS: Original article “Ethics in Medical Research Involving Human Subjects”, written in Macedonian, was submitted as an assay-2 for the subject Ethics and published by Ilina Stefanovska, PhD candidate from the Iustinianus Primus Faculty of Law, Ss Cyril and Methodius University of Skopje (UKIM), Skopje, Republic of Macedonia in Fabruary, 2013. Suspected article for plagiarism was published by Prof. Dr. Gordana Panova from the Faculty of Medical Sciences, University Goce Delchev, Shtip, Republic of Macedonia in English with the identical title and identical content in International scientific on-line journal "SCIENCE & TECHNOLOGIES", Publisher "Union of Scientists - Stara Zagora".RESULTS: Original document (written in Macedonian) was translated with Google Translator; suspected article (published in English pdf file...