Sadia Noor | University of Hohenheim, Stuttgart (original) (raw)
Papers by Sadia Noor
RSC Advances
In this quantum chemical approach, we studied the effect of inserting various π-linkers to reveal... more In this quantum chemical approach, we studied the effect of inserting various π-linkers to reveal the photovoltaic properties of SJ-IC. Results showed that the newly proposed molecules outperformed the reference SJ-IC in the context of photovoltaic properties.
Journal of Molecular Graphics and Modelling
CRC Press eBooks, Mar 3, 2022
The Royal Society of Chemistry eBooks, Dec 3, 2021
Pharmaceutics
The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antim... more The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antimetabolite that has been widely used for its antineoplastic properties. Cocrystals of 5-fluorouracil (5-FU) with five different Schiff bases (benzylidene-urea (BU), benzylidene-aniline (BA), salicylidene-aniline (SA), salicylidene-phenylhydrazine (SPH), and para-hydroxy benzylideneaniline (HBA)) are reported in this study. The newly synthesized cocrystals were analyzed by FTIR and PXRD. In this study, we investigated the antitumor efficacy of 5-FU derivatives in SW480 colon cancer cells via MTT assay at varying dose concentrations. Molecular docking was performed to predict the binding mechanism of TS with various 5-FU complexes. FTIR revealed the presence of respective functional groups in the prepared cocrystals. The frequencies (v) of N-H (3220.24 cm−1) and carbonyl groups (1662.38 cm−1) in the spectrum of 5-FU shifted considerably in all derivative cocrystal new interactions. There wa...
University of Agriculture, Faisalabad., 2019
PLOS ONE
Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared ... more Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation tests on chosen hypoxic cancer cells. Eight substances (Compound 5a, 5c, 5d, 5e, 5g, 5h, 5i, and 5m) showed promising cytotoxicity values compared to the standard control. The potential of compounds was also examined through in silico studies (against human serum albumin), including chem-informatics, to understand the structure-activity relationship (SAR), pharmacochemical strength, and the mode of interactions responsible for their action. The DFT calculations revealed that only the 5b compound showed the lowest ΔET (2.29 eV) while 5i showed relatively highest βtot (69.89 x 10–31 esu), highest αave (3.18 x 10–23 esu), and dipole moment (6.49 Debye). This study presents a novel class of fuberidazole derivatives with selectivity towa...
IBRAS, 2021
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In recent years, the biogenic synthesis of nanoparticle received enormous attention due to simple... more In recent years, the biogenic synthesis of nanoparticle received enormous attention due to simple and eco-friendly path. Here in Jr.NiFe2O4 nanoparticles (NPs) were synthesized first time using the leave extract of Juglans regia via a straightforward process. The physio and phytochemical analysis of plant confirm the presence of macromolecules which function as bio-reductant and stabilize the nanoparticles. The Jr.NiFe2O4 NPs were characterized by UV-visible, FTIR spectroscopy, PXRD pattern, SEM and TGA/ DTA analysis. The nanoparticles proved to be optically active having a value of indirect bandgap of energy in the range of 1.53 eV. Besides, the ciprofloxacin (CIP) and Congo red (CR) degradation ability of Jr.NiFe2O4 NPs were also discussed. It is seen that the highest degradation rate was acquired for CIP using pH = 3, at 254 nm, while 85 % of removal rate was analysed for CR. The kinetic studies in case of CR removal followed pseudo-first-order. Overall, these data recommend an i...
RSC Advances
The developed molecules have a reduced band gap and lower excitation energy. Their VOC was calcul... more The developed molecules have a reduced band gap and lower excitation energy. Their VOC was calculated by making complexes of them with the PTB7-Th donor.
Letters in Organic Chemistry, Apr 6, 2022
Surfaces and Interfaces, 2022
Advanced Oxidation Processes for Wastewater Treatment, 2022
Dyes extracted from natural sources have appeared as important substitutes to synthetic dyes. The... more Dyes extracted from natural sources have appeared as important substitutes to synthetic dyes. The aim of the present study was to optimize the extraction conditions of natural dye from pomegranate peels using central composite design of experiment. The effect of pH of the extraction medium, extraction time and material to liquor ratio (M:L) was investigated. It was found that the pH of the extraction medium has statistically significant effect on dye extraction, whereas the effect of time and M:L, within the ranges used in this study, was not found to be significant. Optimum dye extraction was obtained in alkaline pH of the extraction medium at lower liquor ratio. Cotton fabric dyed with the optimized dye extract, showed very good washing and light fastness properties but slightly poor wet crocking fastness.
Objective: To assess the knowledge of the families of epileptic patients regarding the disease an... more Objective: To assess the knowledge of the families of epileptic patients regarding the disease and to educate them about the treatment options through modern medicine. Methods: Total 100 families (first-degree relatives) of the epileptic patients were registered in this study during their visit to Neurology OPD from 1st December 2016 to 28 February 2017. Patients who have one episode and pseudo-seizure were excluded from study. Results: Thirty-two percent of the population believe epilepsy is contagious and is due to black magic. Thirty-nine percent think it is curse of God, while 38% percent think peers (faith healers) can treat patient in a better way than professional doctors. Similarly, 38% think that shoe sniffing will cure the disease while 28% believe in dung sniffing as a cure for the epilepsy. Total 44% of population believe that patient of epilepsy cannot get education and are infertile therefore cannot get married. Conclusion: Various myths are prevalent in the Pakistani...
Russian Journal of General Chemistry, 2020
Three benzimidazole derivatives, 1-(1H-benzimidazol-2-yl)ethanol (HBE), 1H-benzimidazol-2-yl(diph... more Three benzimidazole derivatives, 1-(1H-benzimidazol-2-yl)ethanol (HBE), 1H-benzimidazol-2-yl(diphenyl)methanol (BDM) and 1,2-bis(1H-benzimidazol-2-yl)ethane-1,2-diol (BHBED), have been synthesized following the one-pot rapid green protocol. Complexes of benzimidazole derivatives with six 3d transition metals, Cu(II), Mn(II), Zn(II), Fe(II), Co(II), and Ni(II), have been synthesized by free hydrothermal method. The synthesized products have been characterized by FTIR, 1H, and 13C NMR, and mass spectroscopy, and CHN analysis, and 2:1 ligand to metal stoichiometry has been confirmed. The synthesized ligands and metal complexes have been tested for antioxidant potential (DPPH), inhibitory activity including inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), α-glucosidase. Micellar solubilization of the metal complexes has been studied in sodium dodecyl sulphate (SDS) by UV-Vis spectroscopy and conductivity. The selected complexes of nickel, zinc and cobalt have demonstrated interaction with SDS, and the value of critical micellar concentration increased in all cases.
Journal of Surfactants and Detergents, 2017
The solubilization and physicochemical behavior of a coordination complex of nickel, namely [Ni(i... more The solubilization and physicochemical behavior of a coordination complex of nickel, namely [Ni(im) 6 ]F 2 Á5H 2 O [hexakis(imidazole)nickel(II) fluoride pentahydrate], in aqueous micellar media of anionic surfactants, i.e., sodium dodecyl sulfate (SDS) and sodium stearate (SS), were investigated by using UV-Vis spectroscopy and electrical conductivity measurements. Spectroscopic techniques were used for the computation of binding constant (K b), partition coefficient (K x), change in free energy of binding (DG b), and change in free energy of partition (DG p), whereas electrical conductivity data was helpful to calculate thermodynamic parameters of micellization of surfactants in the presence of the Ni complex, i.e., standard entropy of micellization (DS m), free energy (DG m), and enthalpy of micellization (DH m). It is evident from the results that solubilization of the Ni complex takes place because of electrostatic as well as hydrophobic interactions. The presence of the Ni complex in micellar media increases the critical micelle concentration of both surfactants owing to the structure-breaking effect.
Asian Journal of Chemistry, 2015
RSC Advances
In this quantum chemical approach, we studied the effect of inserting various π-linkers to reveal... more In this quantum chemical approach, we studied the effect of inserting various π-linkers to reveal the photovoltaic properties of SJ-IC. Results showed that the newly proposed molecules outperformed the reference SJ-IC in the context of photovoltaic properties.
Journal of Molecular Graphics and Modelling
CRC Press eBooks, Mar 3, 2022
The Royal Society of Chemistry eBooks, Dec 3, 2021
Pharmaceutics
The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antim... more The chemotherapeutic agent known as 5-fluorouracil (5-FU) is an artificial fluoropyrimidine antimetabolite that has been widely used for its antineoplastic properties. Cocrystals of 5-fluorouracil (5-FU) with five different Schiff bases (benzylidene-urea (BU), benzylidene-aniline (BA), salicylidene-aniline (SA), salicylidene-phenylhydrazine (SPH), and para-hydroxy benzylideneaniline (HBA)) are reported in this study. The newly synthesized cocrystals were analyzed by FTIR and PXRD. In this study, we investigated the antitumor efficacy of 5-FU derivatives in SW480 colon cancer cells via MTT assay at varying dose concentrations. Molecular docking was performed to predict the binding mechanism of TS with various 5-FU complexes. FTIR revealed the presence of respective functional groups in the prepared cocrystals. The frequencies (v) of N-H (3220.24 cm−1) and carbonyl groups (1662.38 cm−1) in the spectrum of 5-FU shifted considerably in all derivative cocrystal new interactions. There wa...
University of Agriculture, Faisalabad., 2019
PLOS ONE
Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared ... more Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation tests on chosen hypoxic cancer cells. Eight substances (Compound 5a, 5c, 5d, 5e, 5g, 5h, 5i, and 5m) showed promising cytotoxicity values compared to the standard control. The potential of compounds was also examined through in silico studies (against human serum albumin), including chem-informatics, to understand the structure-activity relationship (SAR), pharmacochemical strength, and the mode of interactions responsible for their action. The DFT calculations revealed that only the 5b compound showed the lowest ΔET (2.29 eV) while 5i showed relatively highest βtot (69.89 x 10–31 esu), highest αave (3.18 x 10–23 esu), and dipole moment (6.49 Debye). This study presents a novel class of fuberidazole derivatives with selectivity towa...
IBRAS, 2021
<jats:p>.</jats:p>
In recent years, the biogenic synthesis of nanoparticle received enormous attention due to simple... more In recent years, the biogenic synthesis of nanoparticle received enormous attention due to simple and eco-friendly path. Here in Jr.NiFe2O4 nanoparticles (NPs) were synthesized first time using the leave extract of Juglans regia via a straightforward process. The physio and phytochemical analysis of plant confirm the presence of macromolecules which function as bio-reductant and stabilize the nanoparticles. The Jr.NiFe2O4 NPs were characterized by UV-visible, FTIR spectroscopy, PXRD pattern, SEM and TGA/ DTA analysis. The nanoparticles proved to be optically active having a value of indirect bandgap of energy in the range of 1.53 eV. Besides, the ciprofloxacin (CIP) and Congo red (CR) degradation ability of Jr.NiFe2O4 NPs were also discussed. It is seen that the highest degradation rate was acquired for CIP using pH = 3, at 254 nm, while 85 % of removal rate was analysed for CR. The kinetic studies in case of CR removal followed pseudo-first-order. Overall, these data recommend an i...
RSC Advances
The developed molecules have a reduced band gap and lower excitation energy. Their VOC was calcul... more The developed molecules have a reduced band gap and lower excitation energy. Their VOC was calculated by making complexes of them with the PTB7-Th donor.
Letters in Organic Chemistry, Apr 6, 2022
Surfaces and Interfaces, 2022
Advanced Oxidation Processes for Wastewater Treatment, 2022
Dyes extracted from natural sources have appeared as important substitutes to synthetic dyes. The... more Dyes extracted from natural sources have appeared as important substitutes to synthetic dyes. The aim of the present study was to optimize the extraction conditions of natural dye from pomegranate peels using central composite design of experiment. The effect of pH of the extraction medium, extraction time and material to liquor ratio (M:L) was investigated. It was found that the pH of the extraction medium has statistically significant effect on dye extraction, whereas the effect of time and M:L, within the ranges used in this study, was not found to be significant. Optimum dye extraction was obtained in alkaline pH of the extraction medium at lower liquor ratio. Cotton fabric dyed with the optimized dye extract, showed very good washing and light fastness properties but slightly poor wet crocking fastness.
Objective: To assess the knowledge of the families of epileptic patients regarding the disease an... more Objective: To assess the knowledge of the families of epileptic patients regarding the disease and to educate them about the treatment options through modern medicine. Methods: Total 100 families (first-degree relatives) of the epileptic patients were registered in this study during their visit to Neurology OPD from 1st December 2016 to 28 February 2017. Patients who have one episode and pseudo-seizure were excluded from study. Results: Thirty-two percent of the population believe epilepsy is contagious and is due to black magic. Thirty-nine percent think it is curse of God, while 38% percent think peers (faith healers) can treat patient in a better way than professional doctors. Similarly, 38% think that shoe sniffing will cure the disease while 28% believe in dung sniffing as a cure for the epilepsy. Total 44% of population believe that patient of epilepsy cannot get education and are infertile therefore cannot get married. Conclusion: Various myths are prevalent in the Pakistani...
Russian Journal of General Chemistry, 2020
Three benzimidazole derivatives, 1-(1H-benzimidazol-2-yl)ethanol (HBE), 1H-benzimidazol-2-yl(diph... more Three benzimidazole derivatives, 1-(1H-benzimidazol-2-yl)ethanol (HBE), 1H-benzimidazol-2-yl(diphenyl)methanol (BDM) and 1,2-bis(1H-benzimidazol-2-yl)ethane-1,2-diol (BHBED), have been synthesized following the one-pot rapid green protocol. Complexes of benzimidazole derivatives with six 3d transition metals, Cu(II), Mn(II), Zn(II), Fe(II), Co(II), and Ni(II), have been synthesized by free hydrothermal method. The synthesized products have been characterized by FTIR, 1H, and 13C NMR, and mass spectroscopy, and CHN analysis, and 2:1 ligand to metal stoichiometry has been confirmed. The synthesized ligands and metal complexes have been tested for antioxidant potential (DPPH), inhibitory activity including inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), α-glucosidase. Micellar solubilization of the metal complexes has been studied in sodium dodecyl sulphate (SDS) by UV-Vis spectroscopy and conductivity. The selected complexes of nickel, zinc and cobalt have demonstrated interaction with SDS, and the value of critical micellar concentration increased in all cases.
Journal of Surfactants and Detergents, 2017
The solubilization and physicochemical behavior of a coordination complex of nickel, namely [Ni(i... more The solubilization and physicochemical behavior of a coordination complex of nickel, namely [Ni(im) 6 ]F 2 Á5H 2 O [hexakis(imidazole)nickel(II) fluoride pentahydrate], in aqueous micellar media of anionic surfactants, i.e., sodium dodecyl sulfate (SDS) and sodium stearate (SS), were investigated by using UV-Vis spectroscopy and electrical conductivity measurements. Spectroscopic techniques were used for the computation of binding constant (K b), partition coefficient (K x), change in free energy of binding (DG b), and change in free energy of partition (DG p), whereas electrical conductivity data was helpful to calculate thermodynamic parameters of micellization of surfactants in the presence of the Ni complex, i.e., standard entropy of micellization (DS m), free energy (DG m), and enthalpy of micellization (DH m). It is evident from the results that solubilization of the Ni complex takes place because of electrostatic as well as hydrophobic interactions. The presence of the Ni complex in micellar media increases the critical micelle concentration of both surfactants owing to the structure-breaking effect.
Asian Journal of Chemistry, 2015