Ramdas Pandhare | Savitribai Phule Pune University (original) (raw)
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Analytical Chemistry Letters
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Advanced pharmaceutical bulletin, 2012
An efficient method has been described for synthesis of 6-(substituted aryl)-4-(3,5-diphenyl-1H-1... more An efficient method has been described for synthesis of 6-(substituted aryl)-4-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)-1, 6-dihydropyrimidine-2-thiol, as a beneficial antimicrobial, anticonvulsant and anticancer agents. The clalcones of title compounds were synthesized in three steps and subsequently these chalcones were further reacted with thiourea in the presence of KOH in ethanol, which led to the formation of dihydropyrimidine derivatives (4a-j). Compounds 4a-j were screened for their in vitro antimicrobial activity by agar well method and their anticonvulsant activity by the MES model. Anticancer activity of two newly synthesized heterocycles were evaluated at National Cancer Institute (NCI) Maryland, USA against 60 cell lines of different human tumor at a single dose of 10(-5) M. Compound 4b, 4c, 4d, 4i and 4j were exhibited significant antimicrobial potential against tested strains at 50μg/ml and 100μg/ml concentrations. Out of the ten compounds studied 4a, 4b, 4c, 4h and 4j sh...
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Advanced pharmaceutical bulletin, 2014
An efficient technique has been developed for microwave assisted synthesis of 1-[5-(substituted a... more An efficient technique has been developed for microwave assisted synthesis of 1-[5-(substituted aryl)-1H-pyrazol-3-yl]-3,5-diphenyl-1H-1,2,4-triazole as antinociceptive and antimicrobial agents. The desired compounds (S1-S10) were synthesized by the microwave irradiation via cyclization of formerly synthesized chalcones of 3,5-diphenyl-1H-1,2,4-triazole and hydrazine hydrate in mild acidic condition. All newly synthesized compounds were subjected to study their antinociceptive and antimicrobial activity. The analgesic potential of compounds was tested by acetic acid induced writhing response and hot plate method. The MIC values for antimicrobial activity were premeditated by liquid broth method. The compounds S1, S2, S4, S6 and S10 were found to be excellent peripherally acting analgesic agents when tested on mice by acetic acid induced writhing method and compounds S3, S6 and S1 at dose level of 100 mg/kg were exhibited superior centrally acting antinociceptive activity when tested...
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Advanced pharmaceutical bulletin, 2013
In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole der... more In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated. Acetic acid induced writhing method and Hot plate method has been described to study analgesic activity of some 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine as a pharmacological active lead. Thirty six different derivatives containing 1,2,4-triazole ring were subjected to study their in vivo analgesic activity. Chloro, nitro and methoxy, hydroxy and bromo substituted derivatives showed excellent analgesic activity and dimethylamino, furan and phenyl substituted derivatives showed moderate analgesic activity in both of the methods. Compounds IIIa, IIId, IIIf, IIIi, IIIj, IVa, IVb, IVd, IVf, IVh, IVj IV3a and IIj were found to be superior analgesic agents after screening by Acetic acid induced writhing method. Compounds IIIb, IIId, IIIf, IIIh, IIIj, IVa, IVb, I...
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Advanced pharmaceutical bulletin, 2012
Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both d... more Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both drugs are available in tablet dosage forms with a dose of 150 mg for LAM and 300 mg ZID respectively. The method employed is based on first order derivative spectroscopy. Wavelengths 279 nm and 300 nm were selected for the estimation of the Lamovudine and Zidovudine respectively by taking the first order derivative spectra. The conc. of both drugs was determined by proposed method. The results of analysis have been validated statistically and by recovery studies as per ICH guidelines. Both the drugs obey Beer's law in the concentration range 10-50 μg mL-1,for LAM and ZID; with regression 0.9998 and 0.9999, intercept - 0.0677 and - 0.0043 and slope 0.0457 and 0.0391 for LAM and ZID, respectively.The accuracy and reproducibility results are close to 100% with 2% RSD. A simple, accurate, precise, sensitive and economical procedures for simultaneous estimation of Lamovudine and Zidovudine...
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Bioorganic & Medicinal Chemistry Letters, 2011
A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivative... more A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.
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IJPRIF, 2010
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Avicenna Journal of Phytomedicine
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Revista Brasileira de …, 2012
The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., L... more The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve weeks to assess biochemical alterations. Histopathological evaluations of sciatic nerve were also performed to assess nerve damage. APSAE treatment increased tail flick latency significantly in diabetic rats. APSAE also reduced superoxide anion and total calcium levels. These results suggested that APSAE has attenuated development of diabetic neuropathy in streptozotocin-induced diabetic rats when compared with pregabalin (10 mg/kg, p.o.) and could be beneficial in preventing the progression of diabetic nephropathy.
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Biointerface Research in …
Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition re... more Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 3 and with acetylacetone afforded 1-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone 5. Compound 3 is converted into its corresponding acid hydrazide and then condensed with different aromatic aldehydes to yield Schiff's base, N-[1-arylmethylene]-1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 4. Compound 5 is condensed with aromatic aldehydes to obtain [1-aryl-4-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}prop-2-en-1-ones 6. The newly prepared 1,2,3-triazole derivatives 4 and 6 have been characterized by IR, NMR and mass spectral data. These compounds were screened for their antimicrobial activity.
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Drug Invention …, 2010
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Oriental Pharmacy and …, 2012
In India, Adenanthera pavonina is traditionally used in the treatment of diabetes mellitus and li... more In India, Adenanthera pavonina is traditionally used in the treatment of diabetes mellitus and lipid disorders. In the present study, the antihyperglycaemic and lipid lowering effect of Adenanthera pavonina seed aqueous extract (APSAE) was evaluated using streptozotocin induced diabetes in rats. Streptozotocin was given at the dose of 55 mg/kg, i.p. After induction of diabetes, APSAE was administered for 30 days p. o. and simultaneously different biochemical parameters like plasma glucose, HbA1c, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P<0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P<0.01) in serum HDL-cholesterol and HbA1c. Treatment with APSAE showed significant reduction (P<0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P<0.01) by APSAE. APSAE treatment for 30 days showed significant decrease in serum LDL-cholesterol (P<0.01) and significant increase in serum HDL cholesterol level (P<0.01). Moreover, diabetic control there was significant decrease in HbA1c which was significantly increased (P<0.05) by treatment with APSAE. Hence, from the result obtained in the present study it can be confirmed that Adenanthera pavonina has the potential to treat diabetes condition and associated lipid disorders.
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ajmb.jo.research.ac.ir
Avicenna Journal of Medical Biotechnology.
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... Journal of Brachial Plexus and Peripheral Nerve Injury 5, 13-23. Muthuraman A, Ramesh M, Sood... more ... Journal of Brachial Plexus and Peripheral Nerve Injury 5, 13-23. Muthuraman A, Ramesh M, Sood S (2010). Development of animal model for vasculatic neuropathy:Induction by ischemic-reperfusion in the rat femoral artery. Journal of Neuroscience Methods 186, 215-221. ...
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Oriental Journal of Chemistry, 2009
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Asian Pacific Journal of …, 2012
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Bangladesh Journal of …, 2011
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Biointerface Research in …, 2012
DOAJ Directory of Open Access Journals, SPARC Europe Award 2009 English. Free, full text, quality... more DOAJ Directory of Open Access Journals, SPARC Europe Award 2009 English. Free, full text, quality controlled scientific and scholarly journals, covering all subjects and many languages. ...
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Mar. Pharm …, 2012
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Analytical Chemistry Letters
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Advanced pharmaceutical bulletin, 2012
An efficient method has been described for synthesis of 6-(substituted aryl)-4-(3,5-diphenyl-1H-1... more An efficient method has been described for synthesis of 6-(substituted aryl)-4-(3,5-diphenyl-1H-1,2,4-triazol-1-yl)-1, 6-dihydropyrimidine-2-thiol, as a beneficial antimicrobial, anticonvulsant and anticancer agents. The clalcones of title compounds were synthesized in three steps and subsequently these chalcones were further reacted with thiourea in the presence of KOH in ethanol, which led to the formation of dihydropyrimidine derivatives (4a-j). Compounds 4a-j were screened for their in vitro antimicrobial activity by agar well method and their anticonvulsant activity by the MES model. Anticancer activity of two newly synthesized heterocycles were evaluated at National Cancer Institute (NCI) Maryland, USA against 60 cell lines of different human tumor at a single dose of 10(-5) M. Compound 4b, 4c, 4d, 4i and 4j were exhibited significant antimicrobial potential against tested strains at 50μg/ml and 100μg/ml concentrations. Out of the ten compounds studied 4a, 4b, 4c, 4h and 4j sh...
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Advanced pharmaceutical bulletin, 2014
An efficient technique has been developed for microwave assisted synthesis of 1-[5-(substituted a... more An efficient technique has been developed for microwave assisted synthesis of 1-[5-(substituted aryl)-1H-pyrazol-3-yl]-3,5-diphenyl-1H-1,2,4-triazole as antinociceptive and antimicrobial agents. The desired compounds (S1-S10) were synthesized by the microwave irradiation via cyclization of formerly synthesized chalcones of 3,5-diphenyl-1H-1,2,4-triazole and hydrazine hydrate in mild acidic condition. All newly synthesized compounds were subjected to study their antinociceptive and antimicrobial activity. The analgesic potential of compounds was tested by acetic acid induced writhing response and hot plate method. The MIC values for antimicrobial activity were premeditated by liquid broth method. The compounds S1, S2, S4, S6 and S10 were found to be excellent peripherally acting analgesic agents when tested on mice by acetic acid induced writhing method and compounds S3, S6 and S1 at dose level of 100 mg/kg were exhibited superior centrally acting antinociceptive activity when tested...
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Advanced pharmaceutical bulletin, 2013
In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole der... more In the present study in vivo analgesic activity of some previously synthesized 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine ring have been evaluated. Acetic acid induced writhing method and Hot plate method has been described to study analgesic activity of some 1,2,4-triazole derivatives containing pyrazole, tetrazole, isoxazole and pyrimidine as a pharmacological active lead. Thirty six different derivatives containing 1,2,4-triazole ring were subjected to study their in vivo analgesic activity. Chloro, nitro and methoxy, hydroxy and bromo substituted derivatives showed excellent analgesic activity and dimethylamino, furan and phenyl substituted derivatives showed moderate analgesic activity in both of the methods. Compounds IIIa, IIId, IIIf, IIIi, IIIj, IVa, IVb, IVd, IVf, IVh, IVj IV3a and IIj were found to be superior analgesic agents after screening by Acetic acid induced writhing method. Compounds IIIb, IIId, IIIf, IIIh, IIIj, IVa, IVb, I...
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Advanced pharmaceutical bulletin, 2012
Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both d... more Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both drugs are available in tablet dosage forms with a dose of 150 mg for LAM and 300 mg ZID respectively. The method employed is based on first order derivative spectroscopy. Wavelengths 279 nm and 300 nm were selected for the estimation of the Lamovudine and Zidovudine respectively by taking the first order derivative spectra. The conc. of both drugs was determined by proposed method. The results of analysis have been validated statistically and by recovery studies as per ICH guidelines. Both the drugs obey Beer's law in the concentration range 10-50 μg mL-1,for LAM and ZID; with regression 0.9998 and 0.9999, intercept - 0.0677 and - 0.0043 and slope 0.0457 and 0.0391 for LAM and ZID, respectively.The accuracy and reproducibility results are close to 100% with 2% RSD. A simple, accurate, precise, sensitive and economical procedures for simultaneous estimation of Lamovudine and Zidovudine...
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Bioorganic & Medicinal Chemistry Letters, 2011
A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivative... more A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo. All the synthesized compounds were found to be potent anti-inflammatory agents.
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IJPRIF, 2010
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Avicenna Journal of Phytomedicine
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Revista Brasileira de …, 2012
The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., L... more The aim of present study was to investigate the attenuating effects of Adenanthera pavonina L., Leguminosae-Mimosaceae seeds aqueous extract (APSAE), in streptozotocin (STZ)-induced diabetic neuropathy in rats. APSAE (50, 100 and 200 mg/kg per day) was given to diabetic rats for twelve weeks. Cold and hot water tail immersion tests, photoactometer and Rota-rod tests were performed to assess degree of colder, thermal, spontaneous motor activity and motor co-ordination changes respectively at different time intervals i.e., week 0, 4, 8 and 12. Tissue superoxide anion and total calcium levels were determined after twelve weeks to assess biochemical alterations. Histopathological evaluations of sciatic nerve were also performed to assess nerve damage. APSAE treatment increased tail flick latency significantly in diabetic rats. APSAE also reduced superoxide anion and total calcium levels. These results suggested that APSAE has attenuated development of diabetic neuropathy in streptozotocin-induced diabetic rats when compared with pregabalin (10 mg/kg, p.o.) and could be beneficial in preventing the progression of diabetic nephropathy.
Bookmarks Related papers MentionsView impact
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Biointerface Research in …
Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition re... more Two substituted 1,2,3-triazoles 4 and 6 have been synthesized by the 1,3-dipolar cycloaddition reaction of 4-azido-8-(trifluoromethyl)quinoline 2 with ethyl acetoacetate and acetylacetone, respectively. The reaction of 2 with ethyl acetoacetate afforded 1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 3 and with acetylacetone afforded 1-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone 5. Compound 3 is converted into its corresponding acid hydrazide and then condensed with different aromatic aldehydes to yield Schiff&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s base, N-[1-arylmethylene]-1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazole-4-carbohydrazides 4. Compound 5 is condensed with aromatic aldehydes to obtain [1-aryl-4-{1-[8-(trifluoromethyl)quinolin-4-yl]-5-methyl-1H-1,2,3-triazol-4-yl}prop-2-en-1-ones 6. The newly prepared 1,2,3-triazole derivatives 4 and 6 have been characterized by IR, NMR and mass spectral data. These compounds were screened for their antimicrobial activity.
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Drug Invention …, 2010
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Oriental Pharmacy and …, 2012
In India, Adenanthera pavonina is traditionally used in the treatment of diabetes mellitus and li... more In India, Adenanthera pavonina is traditionally used in the treatment of diabetes mellitus and lipid disorders. In the present study, the antihyperglycaemic and lipid lowering effect of Adenanthera pavonina seed aqueous extract (APSAE) was evaluated using streptozotocin induced diabetes in rats. Streptozotocin was given at the dose of 55 mg/kg, i.p. After induction of diabetes, APSAE was administered for 30 days p. o. and simultaneously different biochemical parameters like plasma glucose, HbA1c, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P<0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P<0.01) in serum HDL-cholesterol and HbA1c. Treatment with APSAE showed significant reduction (P<0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P<0.01) by APSAE. APSAE treatment for 30 days showed significant decrease in serum LDL-cholesterol (P<0.01) and significant increase in serum HDL cholesterol level (P<0.01). Moreover, diabetic control there was significant decrease in HbA1c which was significantly increased (P<0.05) by treatment with APSAE. Hence, from the result obtained in the present study it can be confirmed that Adenanthera pavonina has the potential to treat diabetes condition and associated lipid disorders.
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ajmb.jo.research.ac.ir
Avicenna Journal of Medical Biotechnology.
Bookmarks Related papers MentionsView impact
... Journal of Brachial Plexus and Peripheral Nerve Injury 5, 13-23. Muthuraman A, Ramesh M, Sood... more ... Journal of Brachial Plexus and Peripheral Nerve Injury 5, 13-23. Muthuraman A, Ramesh M, Sood S (2010). Development of animal model for vasculatic neuropathy:Induction by ischemic-reperfusion in the rat femoral artery. Journal of Neuroscience Methods 186, 215-221. ...
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Oriental Journal of Chemistry, 2009
Bookmarks Related papers MentionsView impact
Asian Pacific Journal of …, 2012
Bookmarks Related papers MentionsView impact
Bangladesh Journal of …, 2011
Bookmarks Related papers MentionsView impact
Biointerface Research in …, 2012
DOAJ Directory of Open Access Journals, SPARC Europe Award 2009 English. Free, full text, quality... more DOAJ Directory of Open Access Journals, SPARC Europe Award 2009 English. Free, full text, quality controlled scientific and scholarly journals, covering all subjects and many languages. ...
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Mar. Pharm …, 2012
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Objective: The current study examined the effects of ethanol and aqueous extract of the Thespesia... more Objective: The current study examined the effects of ethanol and aqueous extract of the Thespesia populnea (Malvaceae) seed in normal and alloxan-induced diabetic rats.Materials and Methods: Normal and alloxan-induced rats were given ethanolic extract (200 and 400 mg/kg,) and aqueous extract (200 and 400 mg/kg,) p.o., n=6 of Thespesia populnea (Malvaceae) (TP), vehicle (distilled water, 10 ml/kg, p.o.), standard anti-diabetic drug glibenclamide (0.5 mg/kg, p.o.) for acute study and chronic study. Single-dose study of extracts was performed on normal and diabetic rats blood samples were withdrawn at 2, 4, 6, 8 and 24 h. after drugs treatment. Blood samples were obtained by tail tip cut method and were analyzed for blood glucose level on 1 st , 7 th , 14 th , 21 st , and 28 th days of study by glucometer. In oral glucose tolerance test, glucose (2.5 g/kg, p.o.) was administered to non-diabetic rats and treated with ethanolic extract of T. populnea (EETP) and aqueous extract of T. populnea (AETP) and glibenclamide. The blood glucose level was analyzed at 0, 30, 90, and 150 min after drug administration.Results: Single-dose study of EETP and AETP at two dose level (200 and 400 mg/kg) showed significant (P<0.01) decrease in blood glucose level in normal and diabetic rats at 2, 4, 6 and 8 h. and maximum reduction was observed at 6 h. in acute study. In sub-acute study EETP and AETP at two dose level showed significant (P<0.01) reduction of blood glucose level in alloxan-induced diabetic rats at 21 st and 28 th days of study. In oral glucose tolerance test EETP and AETP at two dose level increased the glucose tolerance.Conclusion: It is concluded that EETP and AETP have significant (P<0.01) hypoglycemic activity as it lowers blood glucose level in normal and diabetic rats and significantly (P<0.01) increases glucose tolerance.
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