Manish Kondawar | Shivaji University, Kolhapur, India (original) (raw)
Papers by Manish Kondawar
International journal of pharmaceutical sciences and drug research, Mar 30, 2023
Advanced Concepts in Pharmaceutical Research Vol. 1
Research Journal of Pharmaceutical Dosage Forms and Technology, 2020
Research Journal of Pharmaceutical Dosage Forms and Technology, 2019
Co-crystals incorporate pharmaceutically acceptable guest molecules into a crystal lattice along ... more Co-crystals incorporate pharmaceutically acceptable guest molecules into a crystal lattice along with the active pharmaceutical ingredience (API). polymorphism in multi-component crystals is gaining interest in the recent times in the context of pharmaceutical co-crystals.the physical and chemical property improvements through pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical science. The aim of this review is to present an extensive overview of the co-crystalization methods, focusing in the specifics of each technique, it's advantages and disadvantages.co-crystals can be prepared from two molecule of any shape or size having complementary hydrogen bond functionalities. Amorphous phases generated by pharmaceutical processes lead to co-crystal formation during cogrinding and storage. Physiochemical properties of drugs can tailored by various approaches such as salt formation, micronization, solid dispertion, amorphous drugs encapsulation.co-crystalization of drug and coformercan affect the crystals packing, tabletability and compaction, which are important parameters during preformulation study. Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constrints during the development of new product.
Research Journal of Pharmacy and Technology, 2020
Desired fused ring system4{1.phenyl-3(Substituted phenyl)-1H-pyrazole-4-yl}-6-phenyl-1,2,3,4 tetr... more Desired fused ring system4{1.phenyl-3(Substituted phenyl)-1H-pyrazole-4-yl}-6-phenyl-1,2,3,4 tetrahydro pyrimidine-2thione & 5-phenyl –s-triazolo[ 1,5,a]pyrimidine (5,a,b) have been synthesized respectively with reaction of (1-phenyl-3-(substituted phenyl)-1Hpyrazol-4yl)-3-phenyl-1-propen-3-one.using a mixture Thiourea & ethanolic sodium ethaoxide & 3.amino .s.triazole. these derivatives 4(a-c) & 5(a-b) screened for analgesic & Antitubercular activity.
Journal of Pharmacognosy and Phytochemistry, 2019
Asian Journal Of Research in Pharmaceutical Science, 2021
Journal of Pharmacognosy and Phytochemistry, 2018
The term "Monographia" is derived from the Greek word "mono" (single) and gra... more The term "Monographia" is derived from the Greek word "mono" (single) and grapho (to write), meaning "writing on a single subject". Unlike a textbook, which surveys the state of knowledge in a field, the main purpose of a monograph is to present primary research and original scholarship. The difficulty associated with development of herbal monograph is that the availability of huge diversity related herbal plant. For this study sample was collected from three different places at different seasons i.e. rainy season winter season, summer season. This parameters was studied, macroscopic, microscopic study, organoleptic evaluation, phytochemical tests, chemical variation study was done, alkaloids, flavonoids, glycosides, saponins.
Pyrazolines are well known, and important nitrogen containing five-membered heterocyclic compound... more Pyrazolines are well known, and important nitrogen containing five-membered heterocyclic compounds. It has been reported to show a broad spectrum of biological activities including antibacterial, antifungal, anti-inflammatory, and antidepressant activities and Its derivatives, possess a wide range of biological and physiological activities such as antitumor, antiarthritic, analgesic, immunosuppressive activities. In view of this various pyrazoline derivatives were synthesized and assessed for the anti-inflammatory activity. In this article new substituted several 1,2 Pyrazoline derivatives were synthesized by reacting Chalcones with hydrazine hydrate in dry benzene. The structures of the synthesized compounds were confirmed by spectral data. Compounds have been screened for antiinflammatory activity by using Carrageenan induced rat hind paw oedema. Among the 7 compounds that were screened for anti-inflammatory activity, compounds SP1 to SP4 showed 30%, 34%, 30% and 32% inhibition of...
RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY, 2021
International Journal of Botany Studies, 2016
This paper represented the therapeutic uses of some species. From an ancient time the spices are ... more This paper represented the therapeutic uses of some species. From an ancient time the spices are used to impart flavor and taste to food. Beside this some of the species have very important medicinal value to treat acute or chronic diseases. They are also popular for their aromatic and pungent taste. Most of species like pepper, garlic, onion, cumin, nutmeg, chilies, clove and asafetida etc. are widely used for their medicinal property as well as for incredible taste. Oleoresin and terpene oils are the most important components from the spices that are popularly known for imparting spicy taste. Both components were found to be useful in medicines. Spices are rich in oleoresins, terpenoids, vitamins, alkaloids, flavonoids, prostaglandins and essential oils.
INTRODUCTION Imidazole and its derivatives have attracted considerable interests in recent years ... more INTRODUCTION Imidazole and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. In the present time imidazole plays an important part in the development of new drug for treatment of cancer activity. Nitrogen containing heterocyclic ring in imidazole possesses biological and pharmaceutical importance. Imidazole (1,3-diaza-2,4-cyclopentadiene) is a planar five-member ring system with 3C and 2N atom in 1 and 3 positions .The simplest member of the imidazole family is imidazole itself, a compound with molecular formula C3H4N2. The systemic name for the compound is 1, 3 diazole, one of the annular N bear a H atom and can be regarded as a pyrole type N. It is soluble in water and other polar solvents. It exists in two equivalent tautomeric forms because the hydrogen atom can be located on either of the two nitrogen atoms. [1]
The purpose of the present study was to develop and optimize the emulgel system for IND (Indometh... more The purpose of the present study was to develop and optimize the emulgel system for IND (Indomethacin), using 2 types of gelling agents: Carbopol 934 and Xanthan Gum. The prepared emulgels were evaluated in terms of appearance, pH, spreadability, viscosity, drug content and in-vitro drug release. In-vitro release study demonstrated diffusion controlled release of IND from formulation up to 12 hours. The drug release profile exhibited zero order kinetics. All the prepared emulgels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability, pH value, and with higher drug release than conventional gel as per USP. The emulgel was optimized using a two factor, two-level factorial design. Influence of type of gelling agent was also investigated. Mathematical equations and response surface plots were used to relate the dependent and independent variables. Each formulation was optimized from carbopol 934 based & from xanthan gum based formulations using...
The aim of the present study was to evaluate the locomotor and diuretic activities of ethanolic e... more The aim of the present study was to evaluate the locomotor and diuretic activities of ethanolic extract of leaves of Capparis divaricata Lam. (EEC) in experimental animals. Locomotor activity was evaluated by actophotometer in mice and diuretic activity was evaluated using in-vivo Lipschitz test model in rats. Oral administration of EEC at doses 250 mg/kg and 500 mg/kg produced significant (P< 0.01) CNS depression by reducing locomotor activity while it showed a significant (P< 0.01) increase in the urine volume when compared to control. Thus, in conclusion the EEC has a significant CNS depression action by reducing locomotor in mice and diuretic action in rats. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, phenolic compounds, glycosides, tannins and saponins.
Asian Journal of Research in Pharmaceutical Science, 2021
Journal of Pharmacy Research, 2016
International journal of pharmaceutical sciences and drug research, Mar 30, 2023
Advanced Concepts in Pharmaceutical Research Vol. 1
Research Journal of Pharmaceutical Dosage Forms and Technology, 2020
Research Journal of Pharmaceutical Dosage Forms and Technology, 2019
Co-crystals incorporate pharmaceutically acceptable guest molecules into a crystal lattice along ... more Co-crystals incorporate pharmaceutically acceptable guest molecules into a crystal lattice along with the active pharmaceutical ingredience (API). polymorphism in multi-component crystals is gaining interest in the recent times in the context of pharmaceutical co-crystals.the physical and chemical property improvements through pharmaceutical co-crystals draw closer the fields of crystal engineering and pharmaceutical science. The aim of this review is to present an extensive overview of the co-crystalization methods, focusing in the specifics of each technique, it's advantages and disadvantages.co-crystals can be prepared from two molecule of any shape or size having complementary hydrogen bond functionalities. Amorphous phases generated by pharmaceutical processes lead to co-crystal formation during cogrinding and storage. Physiochemical properties of drugs can tailored by various approaches such as salt formation, micronization, solid dispertion, amorphous drugs encapsulation.co-crystalization of drug and coformercan affect the crystals packing, tabletability and compaction, which are important parameters during preformulation study. Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constrints during the development of new product.
Research Journal of Pharmacy and Technology, 2020
Desired fused ring system4{1.phenyl-3(Substituted phenyl)-1H-pyrazole-4-yl}-6-phenyl-1,2,3,4 tetr... more Desired fused ring system4{1.phenyl-3(Substituted phenyl)-1H-pyrazole-4-yl}-6-phenyl-1,2,3,4 tetrahydro pyrimidine-2thione & 5-phenyl –s-triazolo[ 1,5,a]pyrimidine (5,a,b) have been synthesized respectively with reaction of (1-phenyl-3-(substituted phenyl)-1Hpyrazol-4yl)-3-phenyl-1-propen-3-one.using a mixture Thiourea & ethanolic sodium ethaoxide & 3.amino .s.triazole. these derivatives 4(a-c) & 5(a-b) screened for analgesic & Antitubercular activity.
Journal of Pharmacognosy and Phytochemistry, 2019
Asian Journal Of Research in Pharmaceutical Science, 2021
Journal of Pharmacognosy and Phytochemistry, 2018
The term "Monographia" is derived from the Greek word "mono" (single) and gra... more The term "Monographia" is derived from the Greek word "mono" (single) and grapho (to write), meaning "writing on a single subject". Unlike a textbook, which surveys the state of knowledge in a field, the main purpose of a monograph is to present primary research and original scholarship. The difficulty associated with development of herbal monograph is that the availability of huge diversity related herbal plant. For this study sample was collected from three different places at different seasons i.e. rainy season winter season, summer season. This parameters was studied, macroscopic, microscopic study, organoleptic evaluation, phytochemical tests, chemical variation study was done, alkaloids, flavonoids, glycosides, saponins.
Pyrazolines are well known, and important nitrogen containing five-membered heterocyclic compound... more Pyrazolines are well known, and important nitrogen containing five-membered heterocyclic compounds. It has been reported to show a broad spectrum of biological activities including antibacterial, antifungal, anti-inflammatory, and antidepressant activities and Its derivatives, possess a wide range of biological and physiological activities such as antitumor, antiarthritic, analgesic, immunosuppressive activities. In view of this various pyrazoline derivatives were synthesized and assessed for the anti-inflammatory activity. In this article new substituted several 1,2 Pyrazoline derivatives were synthesized by reacting Chalcones with hydrazine hydrate in dry benzene. The structures of the synthesized compounds were confirmed by spectral data. Compounds have been screened for antiinflammatory activity by using Carrageenan induced rat hind paw oedema. Among the 7 compounds that were screened for anti-inflammatory activity, compounds SP1 to SP4 showed 30%, 34%, 30% and 32% inhibition of...
RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY, 2021
International Journal of Botany Studies, 2016
This paper represented the therapeutic uses of some species. From an ancient time the spices are ... more This paper represented the therapeutic uses of some species. From an ancient time the spices are used to impart flavor and taste to food. Beside this some of the species have very important medicinal value to treat acute or chronic diseases. They are also popular for their aromatic and pungent taste. Most of species like pepper, garlic, onion, cumin, nutmeg, chilies, clove and asafetida etc. are widely used for their medicinal property as well as for incredible taste. Oleoresin and terpene oils are the most important components from the spices that are popularly known for imparting spicy taste. Both components were found to be useful in medicines. Spices are rich in oleoresins, terpenoids, vitamins, alkaloids, flavonoids, prostaglandins and essential oils.
INTRODUCTION Imidazole and its derivatives have attracted considerable interests in recent years ... more INTRODUCTION Imidazole and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. In the present time imidazole plays an important part in the development of new drug for treatment of cancer activity. Nitrogen containing heterocyclic ring in imidazole possesses biological and pharmaceutical importance. Imidazole (1,3-diaza-2,4-cyclopentadiene) is a planar five-member ring system with 3C and 2N atom in 1 and 3 positions .The simplest member of the imidazole family is imidazole itself, a compound with molecular formula C3H4N2. The systemic name for the compound is 1, 3 diazole, one of the annular N bear a H atom and can be regarded as a pyrole type N. It is soluble in water and other polar solvents. It exists in two equivalent tautomeric forms because the hydrogen atom can be located on either of the two nitrogen atoms. [1]
The purpose of the present study was to develop and optimize the emulgel system for IND (Indometh... more The purpose of the present study was to develop and optimize the emulgel system for IND (Indomethacin), using 2 types of gelling agents: Carbopol 934 and Xanthan Gum. The prepared emulgels were evaluated in terms of appearance, pH, spreadability, viscosity, drug content and in-vitro drug release. In-vitro release study demonstrated diffusion controlled release of IND from formulation up to 12 hours. The drug release profile exhibited zero order kinetics. All the prepared emulgels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability, pH value, and with higher drug release than conventional gel as per USP. The emulgel was optimized using a two factor, two-level factorial design. Influence of type of gelling agent was also investigated. Mathematical equations and response surface plots were used to relate the dependent and independent variables. Each formulation was optimized from carbopol 934 based & from xanthan gum based formulations using...
The aim of the present study was to evaluate the locomotor and diuretic activities of ethanolic e... more The aim of the present study was to evaluate the locomotor and diuretic activities of ethanolic extract of leaves of Capparis divaricata Lam. (EEC) in experimental animals. Locomotor activity was evaluated by actophotometer in mice and diuretic activity was evaluated using in-vivo Lipschitz test model in rats. Oral administration of EEC at doses 250 mg/kg and 500 mg/kg produced significant (P< 0.01) CNS depression by reducing locomotor activity while it showed a significant (P< 0.01) increase in the urine volume when compared to control. Thus, in conclusion the EEC has a significant CNS depression action by reducing locomotor in mice and diuretic action in rats. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, phenolic compounds, glycosides, tannins and saponins.
Asian Journal of Research in Pharmaceutical Science, 2021
Journal of Pharmacy Research, 2016