Nagib A Elmarzugi | Universty Of Tripoli (original) (raw)
Papers by Nagib A Elmarzugi
World Academy of Science, Engineering and Technology, International Journal of Humanities and Social Sciences, Jun 4, 2019
World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering, May 8, 2016
Palestinian Medical and Pharmaceutical Journal
EPH - International Journal of Applied Science
A case study of patient presented with developed wound infection with Pseudomonas aeruginosa (leu... more A case study of patient presented with developed wound infection with Pseudomonas aeruginosa (leukocytosis). The strains of P. aeruginosa isolated from Sheffield General Northern Hospital (UK) and studied for phenotypic and genotypic identifications. This present study were conducted in Sheffield Hallam University (UK) and was aimed to evaluate the application of Phenotypic and Genotypic techniques to identify P. aeruginosa. Generally, the results of Real time PCR (RTPCR) revealed that the diagnosis viability was confirmed for P. aeruginosa. However, identification on the basis of phenotype by differences in types of growth on cetrimide and acetamide agar medium presents that both agars were conducive to the growth of P. aeruginosa. The strains of P. aeruginosa were also tested for antibiotic susceptibility to six different antibiotics, imipenem showed the greatest inhibition effect on the bacteria. It was observed that genetic techniques in accordance with phenotypic tests have fac...
1. Introduction Recently, nanoemulsion hydrogel has been highlighted as one of the most promising... more 1. Introduction Recently, nanoemulsion hydrogel has been highlighted as one of the most promising drug delivery system by reason of their unique ability in combining hydrogel system with nanoemulsion [1]. Hydrogels are polymeric networks with three dimensional structure which have the ability to absorb a great amount of water or biological fluids [2]. Avocado oil has been used as an antioxidant due to the high amount of oleic mono saturated fatty acids in the oil [3]. It also promotes the accumulation of HLD cholesterol that gives health benefits to the cardio vascular system [4]. In addition to that, it is useful as anti- inflammatory agent [5] and in cancer prevention [6]. This study aimed to prepare nanoemulsion hydrogel containing avocado oil for topical application on the skin. 2. Material and Method Avocado oil (Sigma-Aldich, South Africa), Sucrose esters (laureate) (Juhalim, Malaysia), glycerol, and Carbopol (HMBG Chemicals, Malaysia). 3. The results & Discussion The ternary phase diagram constructed and presented in fig 1, was used to aid in finding the concentration range of nano-emulsions components [2]. Sucrose laurate has good emulsification property, which may be due to its excellent miscibility between components in the system. Szuts and Szabo-Revesz; Leong et al., found that nanoemulsion that used high HLB value like sucrose laurate as surfactant has good emulsification properties [7]. 4. Conclusıon In the current investigation, the optimum Avocado oil nanoemulsion was prepared by heat inversion and self- emulsification techniques with a composition (60% w/w oil, 16% w/w Stearate and 24% w/w glycerol). After achieving nanoemulsion, it was mixed with Carbopol and water to produce nanoemulsion hydrogel. The droplets size of nanoemulsions hydrogel were less than 200 nm with PDI below 0.2 and Low negative zeta potential > -30, which indicate that the formulations are stable. Finally, Rheology test for nanoemulsions hydrogel showed an increase with the increase in the oil concentration and the inclusion of Carbopol.
New methods of drug delivery can now be used to increase the effectiveness and safety of medicati... more New methods of drug delivery can now be used to increase the effectiveness and safety of medication. Therefore, several new drug carrier systems have been developed such as nanoemulsions Nanoemulsion is submicron sized emulsion Typically in the range of 20-200 cm, Avocado oil is often used in herbal skin care. The aim of this study was to characterize nanoemulsion hydrogel prepared using avocado oil and sucrose ester stearate as surfactant. The nanoemulsion hydrogel were prepared by nanophase emulsification technique. These forrnulations were examined using zetasizer to determined the mean diameter of dispersed oil droplets, polydispersibility index (PD1) and zeta potential. Also the viscosity of the prepared nanoemulslon hydrogel were studied. The results reveled that nanoemulson prepared with 60% w/w oil, 24% w/w glycerol and 16%w/w surfactant showed droplets size below 200 nm with good polydispersibility index and zeta potential < -30 mV. The optimum formulation of nanoemulsio...
VCO Emulsions were prepared using high-speed stirre r with various surfactant concentrations and ... more VCO Emulsions were prepared using high-speed stirre r with various surfactant concentrations and mixing ratio. The resultant mixture was added with distilled wate r. Among the formulation, best optimum formulation was selected for secondary homogenization using High Pr essure Homogenizer (HPH) to produce of VCO Nanoemul sion in the range 20-200nm. The secondary homogenization pr cess involves using variable parameter of press ure and homogenization cycle number. According to the resul ts the VCO Nanoemulsion consists of 20% of VCO, 5% surfactant and 75% distilled water. 5% of the optim um VCO Nanoemulsion formulations with the smallest droplet size 153nm and Poly Dispersed Index (PDI) value of 0.139 were selected to incorporate with a 0.5% hydr ogel concentration and distilled water mixed to produce VCO Nanoemulgel. Based on the characterization of V CO Nanoemulgel with droplet size of 163nm and 0.211 PD I value, low viscosity and pH value of 5.6-6.0 were suitable for topical usage ...
Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the ra... more Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range of 20-200 nm. Nanoemulsion provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf live upon preserving the therapeutic agents. Incorporating the preparation of nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed, emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance. Keywords-Nanoemulsion, Nanoemulgel, Emulsifying method, Liposomes, Thixotropic, Hydrogel
Historical calcareous stone surfaces may undergo unwanted changes due to the exposure to many phy... more Historical calcareous stone surfaces may undergo unwanted changes due to the exposure to many physical and chemical deterioration factors. This paper evaluates the use of zinc oxide nanoparticles, dispersed in a laboratorial prepared acrylic copolymer [polyethylmethacrylate/methylacrylate (70:30) (Poly EMA/MA)], as a nanocomposite coating material with hydrophobic, consolidating and protecting properties against artificial aging by relative humidity/temperature, UV radiation and dirt accumulation. The obtained nanocomposites have been characterized by transimition electron microscopy (TEM) to ensure the homogenous dispersion of ZnO nanoparticles in the polymer matrix and the average crystal size. Marble stone blocks have been prepared and coated by the nanocomposite material, the efficiency of the treatments has been evaluated after coating and artificial aging, through capillary water absorption, Ultraviolet-light exposure to evaluate photo-induced and the hydrophobic effects of th...
World Academy of Science, Engineering and Technology, International Journal of Humanities and Social Sciences, 2016
Alexandria Journal of Veterinary Sciences, 2017
Nanomedicine & Nanotechnology Open Access, 2016
Hylocereusundatus is typically the most cultivated vine cactus belonging to the family of Cactace... more Hylocereusundatus is typically the most cultivated vine cactus belonging to the family of Cactaceae, originating natively from Mexico and America. Commonly, it is well known under the name of " dragon fruit " or " pitaya ". In Malaysia, it is also called 'buahnaga' which gives the meaning of dragon fruit. Besides its attractive coloration, the fruits of Hylocereusundatus are being prevailed globally because of its rich source of polyphenolic components and their antioxidant activity. A wide ranging of phytochemicals of betalains, polyphenolic compounds and carotenoids are discovered to possess chemo-protective properties against oxidant stress in the body as well as maintain optimum equilibrium between antioxidants and oxidants for the enhancement of human health. The findings of this review are important to deliver an overview of Hylocereusundatus and its functional phytochemicals, with relation to its potential health benefit in providing perspectives of research and application. It presented more environmental benign antioxidant and antibacterial agents that are significant in the fields of healthcare, food processing, nutraceutical and cosmeceutical. Therefore, there should be a collective work by scientists and researchers to maximize the value chain of this fruit to global cultivars in order to expand the global market of dragon fruit.
Journal of Physics: Conference Series, 2017
Journal of Materials Science and Engineering A, 2016
Journal of Chemical and Pharmaceutical Research
Journal of Applied Pharmaceutical Science, 2014
Asian Journal of Pharmaceutical and Clinical Research
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new prod... more Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal, vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits. Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three different types of sucrose ...
World Academy of Science, Engineering and Technology, International Journal of Humanities and Social Sciences, Jun 4, 2019
World Academy of Science, Engineering and Technology, International Journal of Chemical and Molecular Engineering, May 8, 2016
Palestinian Medical and Pharmaceutical Journal
EPH - International Journal of Applied Science
A case study of patient presented with developed wound infection with Pseudomonas aeruginosa (leu... more A case study of patient presented with developed wound infection with Pseudomonas aeruginosa (leukocytosis). The strains of P. aeruginosa isolated from Sheffield General Northern Hospital (UK) and studied for phenotypic and genotypic identifications. This present study were conducted in Sheffield Hallam University (UK) and was aimed to evaluate the application of Phenotypic and Genotypic techniques to identify P. aeruginosa. Generally, the results of Real time PCR (RTPCR) revealed that the diagnosis viability was confirmed for P. aeruginosa. However, identification on the basis of phenotype by differences in types of growth on cetrimide and acetamide agar medium presents that both agars were conducive to the growth of P. aeruginosa. The strains of P. aeruginosa were also tested for antibiotic susceptibility to six different antibiotics, imipenem showed the greatest inhibition effect on the bacteria. It was observed that genetic techniques in accordance with phenotypic tests have fac...
1. Introduction Recently, nanoemulsion hydrogel has been highlighted as one of the most promising... more 1. Introduction Recently, nanoemulsion hydrogel has been highlighted as one of the most promising drug delivery system by reason of their unique ability in combining hydrogel system with nanoemulsion [1]. Hydrogels are polymeric networks with three dimensional structure which have the ability to absorb a great amount of water or biological fluids [2]. Avocado oil has been used as an antioxidant due to the high amount of oleic mono saturated fatty acids in the oil [3]. It also promotes the accumulation of HLD cholesterol that gives health benefits to the cardio vascular system [4]. In addition to that, it is useful as anti- inflammatory agent [5] and in cancer prevention [6]. This study aimed to prepare nanoemulsion hydrogel containing avocado oil for topical application on the skin. 2. Material and Method Avocado oil (Sigma-Aldich, South Africa), Sucrose esters (laureate) (Juhalim, Malaysia), glycerol, and Carbopol (HMBG Chemicals, Malaysia). 3. The results & Discussion The ternary phase diagram constructed and presented in fig 1, was used to aid in finding the concentration range of nano-emulsions components [2]. Sucrose laurate has good emulsification property, which may be due to its excellent miscibility between components in the system. Szuts and Szabo-Revesz; Leong et al., found that nanoemulsion that used high HLB value like sucrose laurate as surfactant has good emulsification properties [7]. 4. Conclusıon In the current investigation, the optimum Avocado oil nanoemulsion was prepared by heat inversion and self- emulsification techniques with a composition (60% w/w oil, 16% w/w Stearate and 24% w/w glycerol). After achieving nanoemulsion, it was mixed with Carbopol and water to produce nanoemulsion hydrogel. The droplets size of nanoemulsions hydrogel were less than 200 nm with PDI below 0.2 and Low negative zeta potential > -30, which indicate that the formulations are stable. Finally, Rheology test for nanoemulsions hydrogel showed an increase with the increase in the oil concentration and the inclusion of Carbopol.
New methods of drug delivery can now be used to increase the effectiveness and safety of medicati... more New methods of drug delivery can now be used to increase the effectiveness and safety of medication. Therefore, several new drug carrier systems have been developed such as nanoemulsions Nanoemulsion is submicron sized emulsion Typically in the range of 20-200 cm, Avocado oil is often used in herbal skin care. The aim of this study was to characterize nanoemulsion hydrogel prepared using avocado oil and sucrose ester stearate as surfactant. The nanoemulsion hydrogel were prepared by nanophase emulsification technique. These forrnulations were examined using zetasizer to determined the mean diameter of dispersed oil droplets, polydispersibility index (PD1) and zeta potential. Also the viscosity of the prepared nanoemulslon hydrogel were studied. The results reveled that nanoemulson prepared with 60% w/w oil, 24% w/w glycerol and 16%w/w surfactant showed droplets size below 200 nm with good polydispersibility index and zeta potential < -30 mV. The optimum formulation of nanoemulsio...
VCO Emulsions were prepared using high-speed stirre r with various surfactant concentrations and ... more VCO Emulsions were prepared using high-speed stirre r with various surfactant concentrations and mixing ratio. The resultant mixture was added with distilled wate r. Among the formulation, best optimum formulation was selected for secondary homogenization using High Pr essure Homogenizer (HPH) to produce of VCO Nanoemul sion in the range 20-200nm. The secondary homogenization pr cess involves using variable parameter of press ure and homogenization cycle number. According to the resul ts the VCO Nanoemulsion consists of 20% of VCO, 5% surfactant and 75% distilled water. 5% of the optim um VCO Nanoemulsion formulations with the smallest droplet size 153nm and Poly Dispersed Index (PDI) value of 0.139 were selected to incorporate with a 0.5% hydr ogel concentration and distilled water mixed to produce VCO Nanoemulgel. Based on the characterization of V CO Nanoemulgel with droplet size of 163nm and 0.211 PD I value, low viscosity and pH value of 5.6-6.0 were suitable for topical usage ...
Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the ra... more Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range of 20-200 nm. Nanoemulsion provides numerous advantages over other carrier such as polymeric nanoparticle and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system to enhance the longer shelf live upon preserving the therapeutic agents. Incorporating the preparation of nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed, emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance. Keywords-Nanoemulsion, Nanoemulgel, Emulsifying method, Liposomes, Thixotropic, Hydrogel
Historical calcareous stone surfaces may undergo unwanted changes due to the exposure to many phy... more Historical calcareous stone surfaces may undergo unwanted changes due to the exposure to many physical and chemical deterioration factors. This paper evaluates the use of zinc oxide nanoparticles, dispersed in a laboratorial prepared acrylic copolymer [polyethylmethacrylate/methylacrylate (70:30) (Poly EMA/MA)], as a nanocomposite coating material with hydrophobic, consolidating and protecting properties against artificial aging by relative humidity/temperature, UV radiation and dirt accumulation. The obtained nanocomposites have been characterized by transimition electron microscopy (TEM) to ensure the homogenous dispersion of ZnO nanoparticles in the polymer matrix and the average crystal size. Marble stone blocks have been prepared and coated by the nanocomposite material, the efficiency of the treatments has been evaluated after coating and artificial aging, through capillary water absorption, Ultraviolet-light exposure to evaluate photo-induced and the hydrophobic effects of th...
World Academy of Science, Engineering and Technology, International Journal of Humanities and Social Sciences, 2016
Alexandria Journal of Veterinary Sciences, 2017
Nanomedicine & Nanotechnology Open Access, 2016
Hylocereusundatus is typically the most cultivated vine cactus belonging to the family of Cactace... more Hylocereusundatus is typically the most cultivated vine cactus belonging to the family of Cactaceae, originating natively from Mexico and America. Commonly, it is well known under the name of " dragon fruit " or " pitaya ". In Malaysia, it is also called 'buahnaga' which gives the meaning of dragon fruit. Besides its attractive coloration, the fruits of Hylocereusundatus are being prevailed globally because of its rich source of polyphenolic components and their antioxidant activity. A wide ranging of phytochemicals of betalains, polyphenolic compounds and carotenoids are discovered to possess chemo-protective properties against oxidant stress in the body as well as maintain optimum equilibrium between antioxidants and oxidants for the enhancement of human health. The findings of this review are important to deliver an overview of Hylocereusundatus and its functional phytochemicals, with relation to its potential health benefit in providing perspectives of research and application. It presented more environmental benign antioxidant and antibacterial agents that are significant in the fields of healthcare, food processing, nutraceutical and cosmeceutical. Therefore, there should be a collective work by scientists and researchers to maximize the value chain of this fruit to global cultivars in order to expand the global market of dragon fruit.
Journal of Physics: Conference Series, 2017
Journal of Materials Science and Engineering A, 2016
Journal of Chemical and Pharmaceutical Research
Journal of Applied Pharmaceutical Science, 2014
Asian Journal of Pharmaceutical and Clinical Research
Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new prod... more Objectives: Due to the high dynamics of pharmaceutical products markets, developments of new products using latest innovative technology are becoming a norm of many pharmaceutical companies. Nanoscale materials such as nanoemulsion (NE) offer advantages such as the controllable droplet size, long-term stability, and power solubilization ability. It is beneficial in various delivery systems either for transdermal, ocular, nasal, vaginal, and parenteral drug delivery. The objective of the study was to prepare avocado oil NE using different surfactants to find the most suitable nanosized droplets, as avocado oil offers a variety of purported nutritional and medicinal benefits. Methods: Sucrose esters, glycerol, and avocado oil with different ratio were used to produce pre-NE by phase inversion technique then pre-NE were self-emulsified with water to produce NE. The influence of the sucrose esters surfactants on the NE formulations were determined using three different types of sucrose ...