Esther Cuerda | Universidad Rey Juan Carlos (original) (raw)
Papers by Esther Cuerda
Even after the Nuremberg code was published, research on syphilis often continued to fall far sho... more Even after the Nuremberg code was published, research on syphilis often continued to fall far short of ethical standards. We review post-World War II research on this disease, focusing on the work carried out in Guatemala and Tuskegee. Over a thousand adults were deliberately inoculated with infectious material for syphilis, chancroid, and gonorrhea between 1946 and 1948 in Guatemala, and thousands of serologies were performed in individuals belonging to indigenous populations or sheltered in orphanages. The Tuskegee syphilis study, conducted by the US Public Health Service, took place between 1932 and 1972 with the aim of following the natural history of the disease when left untreated. The subjects belonged to a rural black population and the study was not halted when effective treatment for syphilis became available in 1945.
Physicians have conducted research on syphilis for centuries, seeking to understand its etiology ... more Physicians have conducted research on syphilis for centuries, seeking to understand its etiology and the means of transmission as well as find ways to prevent and cure the disease. Their research practices often strayed from today's ethical standards. In this paper we review ethical aspects of the long history of research on syphilis with emphasis on the experiments performed in the 20th century. The description of research around the time of World War II covers medical experiments carried out in US prisons and in the experimentation centers established by Japanese doctors in occupied territory, as well as experiments in Nazi Germany and the treatment of syphilitics there.
Journal of The European Academy of Dermatology and Venereology, 2004
The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common ... more The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common causes of FDE is the use of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams are in the NSAID group and piroxicam is one of the most used of these drugs. FDE caused by piroxicam is rare but a few cases have been reported. Patch tests are useful for diagnosing some cases of FDE; they give variable results on previously affected skin while no reaction appears on unaffected skin. Some cases of cross-sensitivity among piroxicam and other substances have been reported. We report two new cases of FDE due to piroxicam with negative patch test on normal skin and positive results on affected skin.
Contact Dermatitis, 2008
Introduction: Cutaneous reactions due to use of non-steroidal anti-inflammatory drugs (NSAID) ar... more Introduction: Cutaneous reactions due to use of non-steroidal anti-inflammatory drugs (NSAID) are frequently described. In the Contact Unit from the Department of Dermatology of Juan Canalejo Hospital, we compiled all cases studied during 4 years (from 2000 to 2003) to analyze the incidence, frequency and type of reactions derived from NSAIDs use.Material and methods: We used a NAIDs battery (Aristegui lab.Ò) on 55 patients with clinical suspicion of adverse reaction from NSAIDs. We performed epicutaneous study on 17 and additional photoallergic study, after UVA irradiation (from 5 to 7,5 J/cm2), on 38 cases. In some cases we patched the drug used by patient as is and/or the active substance provided by the laboratory if it was not included on NSAIDs battery. Readings were done following ICDRG criteria at 48 and 96 hours on patch tests and 24 and 72 hours on photopatch tests. Healthy controls were patched.Results: 22 patients showed positive test: 15 cases were diagnosed as photoallergic dermatitis (etofenamate 5; dexketoprofen 4; ketoprofen 3; piroxicam 2; diclophenac 2 and aceclophenac 1). Five cases were explained as allergic contact dermatitis (etofenamate 2; fepradinol 2 and phenylbutazone 1) and two cases of fixed drug eruption from piroxicam were found.Conclusion: In this study we observed that cutaneous reactions due to ketoprofen and piroxicam are still high. It is important to note the high incidence of allergic and photoallergic reactions from dexketoprofen, a recently introduced NSAID, reporting always a cross reaction between ketoprofen and dexketoprofen.
Contact Dermatitis, 2008
Introduction: Cutaneous adverse reactions from topical or systemic administration of non-steroid... more Introduction: Cutaneous adverse reactions from topical or systemic administration of non-steroidal anti-inflammatory drugs (NSAID) are frequently described. New cases of adverse reactions from NSAIDs are reported, but the most frequently involved are drugs as ketoprofen or piroxicam. We report a case of photoallergical contact dermatitis from diclophenac with possible cross reaction to aceclophenac.Material and methods: A 63-year-old-man, allergic to penicillin, developed eczematous lesions on hands and face, after applying a medicament containing diclophenac. Patch test and photopatch test (5 J/cm2) were performed with a photoallergen battery (Chemotechnique diagnosticsÒ), a NSAIDs battery (Aristegui lab.Ò) and aceclophenac 1%, 5% and 10% in pet. Readings were done at 48 and 96 hours in epicutaneous test and at 24 and 72 hours in photoallergic study, following the ICDRG criteria.Results: The results of photoallergic study were as follows: diclophenac 1%, 5% and 10% in pet. and aceclophenac 10% in pet. positive at 24 and 72 hours. The remaining compounds of the NSAIDs battery were negative.Conclusions: Diclophenac is a NAIDs derived from aryl alcanoic acid group used both topically and systemically in Spain. Some adverse reactions have been reported as exanthema, urticaria, eczema or Steven-Johnson’s syndrome. We have found only two cases reported as photosensitization from diclophenac. In one of them, the clinical lesion was described as a granuloma annular-like and photoallergic study was negative. We report a photocontact dermatitis from diclophenac with positive photopatch test. Photopatch test positive to aceclophenac may be explained as a cross reaction among group.
Cómo citar este artículo: Cuerda-Galindo E, et al. La sífilis y la experimentación en humanos: pe... more Cómo citar este artículo: Cuerda-Galindo E, et al. La sífilis y la experimentación en humanos: perspectiva histórica y reflexiones éticas. De la Segunda Guerra Mundial a la actualidad. Actas Dermosifiliogr. 2014.
Actas Dermosifiliogr, Jan 1, 2000
... Oral Surg Oral Med Oral Pathol 1993;76:480-3. 9. Miko TL, Molnar P, Vereckei L ... JOSÉ GREGO... more ... Oral Surg Oral Med Oral Pathol 1993;76:480-3. 9. Miko TL, Molnar P, Vereckei L ... JOSÉ GREGORIO ÁLVAREZ-FERNÁNDEZ*, ISABEL POLIMÓN-OLABARRIETA***, AGUSTÍN ACEVEDO-BARBERÁ** , MARIANO ZOMEÑO-GÓMEZ**, RICARDO RUIZ-RODRÍGUEZ* *Unidad de ...
Cutis, Jan 1, 2001
Lupus erythematosus profundus is a rare manifestation of lupus. We conducted a study to observe t... more Lupus erythematosus profundus is a rare manifestation of lupus. We conducted a study to observe the epidemiologic and clinical aspects of lupus erythematosus profundus, its development into other types of lupus or systemic disease, and its response to treatment. Six patients were followed for variable periods. We conclude that lupus erythematosus profundus is a benign form of lupus, distinguishable by systemic manifestations, clinical evolution and resolution, and heterogeneity in clinical manifestations. A skin biopsy is necessary to make an accurate diagnosis.
Piel, Jan 1, 2003
El síndrome del nevus azul en tetina de goma o síndrome blue rubber bleb nevus (BRBN) es una enti... more El síndrome del nevus azul en tetina de goma o síndrome blue rubber bleb nevus (BRBN) es una entidad de escasa incidencia, pero bien definida, que se caracteriza por la existencia de hemangiomas cavernosos cutáneos asociados con el mismo tipo de ...
Actas dermo- …, Jan 1, 2002
Résumé/Abstract We report a case of allergic contact dermatitis from tetracaine in a 33 year old ... more Résumé/Abstract We report a case of allergic contact dermatitis from tetracaine in a 33 year old woman had care of her child with cerebral paralysis; she made vesical soundings of the child using Drganon® as lubricant. We discuss it mother's sensitizacion maybe ...
Actas dermo- …, Jan 1, 2000
codem.es
La lipoatrofia semicircular (LS) es una entidad poco frecuente de la que hay pocos casos descrito... more La lipoatrofia semicircular (LS) es una entidad poco frecuente de la que hay pocos casos descritos (1). Consiste en una depresión lineal que afecta a miembros inferiores y la etiología hasta el día de hoy es desconocida (2). Se han implicado algunos agentes ...
Actas dermo- …, Jan 1, 2002
A new case of multiple minute digitate hyper ker atoses (M M DH) is r epor ted. Hundr eds of spik... more A new case of multiple minute digitate hyper ker atoses (M M DH) is r epor ted. Hundr eds of spiked and ker atotic papules wer e distr ibuted on tr unk, axilae and limbs, with no palmoplantar or hair follicule affection. Histologically these lesions showed hyper ker atosis or thoker atotic. M M DH has thr ee clinical pr esentation: familial, spor adic and postinflammator y. All gr oups ar e clinically indistinguishable but histologically some impor tant differ ences exist between familial or spor adic type and postinflammator y type.
Contact …, Jan 1, 2004
... observe a rare bird. FS01.4 Hailey Hailey disease a significant hazard to consider when pat... more ... observe a rare bird. FS01.4 Hailey Hailey disease a significant hazard to consider when patch testing S Walker, Jason Williams, JO'Driscoll, M Beck Dermatology Centre, University of Manchester, Manchester, UK A 42 year old ...
Even after the Nuremberg code was published, research on syphilis often continued to fall far sho... more Even after the Nuremberg code was published, research on syphilis often continued to fall far short of ethical standards. We review post-World War II research on this disease, focusing on the work carried out in Guatemala and Tuskegee. Over a thousand adults were deliberately inoculated with infectious material for syphilis, chancroid, and gonorrhea between 1946 and 1948 in Guatemala, and thousands of serologies were performed in individuals belonging to indigenous populations or sheltered in orphanages. The Tuskegee syphilis study, conducted by the US Public Health Service, took place between 1932 and 1972 with the aim of following the natural history of the disease when left untreated. The subjects belonged to a rural black population and the study was not halted when effective treatment for syphilis became available in 1945.
Physicians have conducted research on syphilis for centuries, seeking to understand its etiology ... more Physicians have conducted research on syphilis for centuries, seeking to understand its etiology and the means of transmission as well as find ways to prevent and cure the disease. Their research practices often strayed from today's ethical standards. In this paper we review ethical aspects of the long history of research on syphilis with emphasis on the experiments performed in the 20th century. The description of research around the time of World War II covers medical experiments carried out in US prisons and in the experimentation centers established by Japanese doctors in occupied territory, as well as experiments in Nazi Germany and the treatment of syphilitics there.
Journal of The European Academy of Dermatology and Venereology, 2004
The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common ... more The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common causes of FDE is the use of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams are in the NSAID group and piroxicam is one of the most used of these drugs. FDE caused by piroxicam is rare but a few cases have been reported. Patch tests are useful for diagnosing some cases of FDE; they give variable results on previously affected skin while no reaction appears on unaffected skin. Some cases of cross-sensitivity among piroxicam and other substances have been reported. We report two new cases of FDE due to piroxicam with negative patch test on normal skin and positive results on affected skin.
Contact Dermatitis, 2008
Introduction: Cutaneous reactions due to use of non-steroidal anti-inflammatory drugs (NSAID) ar... more Introduction: Cutaneous reactions due to use of non-steroidal anti-inflammatory drugs (NSAID) are frequently described. In the Contact Unit from the Department of Dermatology of Juan Canalejo Hospital, we compiled all cases studied during 4 years (from 2000 to 2003) to analyze the incidence, frequency and type of reactions derived from NSAIDs use.Material and methods: We used a NAIDs battery (Aristegui lab.Ò) on 55 patients with clinical suspicion of adverse reaction from NSAIDs. We performed epicutaneous study on 17 and additional photoallergic study, after UVA irradiation (from 5 to 7,5 J/cm2), on 38 cases. In some cases we patched the drug used by patient as is and/or the active substance provided by the laboratory if it was not included on NSAIDs battery. Readings were done following ICDRG criteria at 48 and 96 hours on patch tests and 24 and 72 hours on photopatch tests. Healthy controls were patched.Results: 22 patients showed positive test: 15 cases were diagnosed as photoallergic dermatitis (etofenamate 5; dexketoprofen 4; ketoprofen 3; piroxicam 2; diclophenac 2 and aceclophenac 1). Five cases were explained as allergic contact dermatitis (etofenamate 2; fepradinol 2 and phenylbutazone 1) and two cases of fixed drug eruption from piroxicam were found.Conclusion: In this study we observed that cutaneous reactions due to ketoprofen and piroxicam are still high. It is important to note the high incidence of allergic and photoallergic reactions from dexketoprofen, a recently introduced NSAID, reporting always a cross reaction between ketoprofen and dexketoprofen.
Contact Dermatitis, 2008
Introduction: Cutaneous adverse reactions from topical or systemic administration of non-steroid... more Introduction: Cutaneous adverse reactions from topical or systemic administration of non-steroidal anti-inflammatory drugs (NSAID) are frequently described. New cases of adverse reactions from NSAIDs are reported, but the most frequently involved are drugs as ketoprofen or piroxicam. We report a case of photoallergical contact dermatitis from diclophenac with possible cross reaction to aceclophenac.Material and methods: A 63-year-old-man, allergic to penicillin, developed eczematous lesions on hands and face, after applying a medicament containing diclophenac. Patch test and photopatch test (5 J/cm2) were performed with a photoallergen battery (Chemotechnique diagnosticsÒ), a NSAIDs battery (Aristegui lab.Ò) and aceclophenac 1%, 5% and 10% in pet. Readings were done at 48 and 96 hours in epicutaneous test and at 24 and 72 hours in photoallergic study, following the ICDRG criteria.Results: The results of photoallergic study were as follows: diclophenac 1%, 5% and 10% in pet. and aceclophenac 10% in pet. positive at 24 and 72 hours. The remaining compounds of the NSAIDs battery were negative.Conclusions: Diclophenac is a NAIDs derived from aryl alcanoic acid group used both topically and systemically in Spain. Some adverse reactions have been reported as exanthema, urticaria, eczema or Steven-Johnson’s syndrome. We have found only two cases reported as photosensitization from diclophenac. In one of them, the clinical lesion was described as a granuloma annular-like and photoallergic study was negative. We report a photocontact dermatitis from diclophenac with positive photopatch test. Photopatch test positive to aceclophenac may be explained as a cross reaction among group.
Cómo citar este artículo: Cuerda-Galindo E, et al. La sífilis y la experimentación en humanos: pe... more Cómo citar este artículo: Cuerda-Galindo E, et al. La sífilis y la experimentación en humanos: perspectiva histórica y reflexiones éticas. De la Segunda Guerra Mundial a la actualidad. Actas Dermosifiliogr. 2014.
Actas Dermosifiliogr, Jan 1, 2000
... Oral Surg Oral Med Oral Pathol 1993;76:480-3. 9. Miko TL, Molnar P, Vereckei L ... JOSÉ GREGO... more ... Oral Surg Oral Med Oral Pathol 1993;76:480-3. 9. Miko TL, Molnar P, Vereckei L ... JOSÉ GREGORIO ÁLVAREZ-FERNÁNDEZ*, ISABEL POLIMÓN-OLABARRIETA***, AGUSTÍN ACEVEDO-BARBERÁ** , MARIANO ZOMEÑO-GÓMEZ**, RICARDO RUIZ-RODRÍGUEZ* *Unidad de ...
Cutis, Jan 1, 2001
Lupus erythematosus profundus is a rare manifestation of lupus. We conducted a study to observe t... more Lupus erythematosus profundus is a rare manifestation of lupus. We conducted a study to observe the epidemiologic and clinical aspects of lupus erythematosus profundus, its development into other types of lupus or systemic disease, and its response to treatment. Six patients were followed for variable periods. We conclude that lupus erythematosus profundus is a benign form of lupus, distinguishable by systemic manifestations, clinical evolution and resolution, and heterogeneity in clinical manifestations. A skin biopsy is necessary to make an accurate diagnosis.
Piel, Jan 1, 2003
El síndrome del nevus azul en tetina de goma o síndrome blue rubber bleb nevus (BRBN) es una enti... more El síndrome del nevus azul en tetina de goma o síndrome blue rubber bleb nevus (BRBN) es una entidad de escasa incidencia, pero bien definida, que se caracteriza por la existencia de hemangiomas cavernosos cutáneos asociados con el mismo tipo de ...
Actas dermo- …, Jan 1, 2002
Résumé/Abstract We report a case of allergic contact dermatitis from tetracaine in a 33 year old ... more Résumé/Abstract We report a case of allergic contact dermatitis from tetracaine in a 33 year old woman had care of her child with cerebral paralysis; she made vesical soundings of the child using Drganon® as lubricant. We discuss it mother's sensitizacion maybe ...
Actas dermo- …, Jan 1, 2000
codem.es
La lipoatrofia semicircular (LS) es una entidad poco frecuente de la que hay pocos casos descrito... more La lipoatrofia semicircular (LS) es una entidad poco frecuente de la que hay pocos casos descritos (1). Consiste en una depresión lineal que afecta a miembros inferiores y la etiología hasta el día de hoy es desconocida (2). Se han implicado algunos agentes ...
Actas dermo- …, Jan 1, 2002
A new case of multiple minute digitate hyper ker atoses (M M DH) is r epor ted. Hundr eds of spik... more A new case of multiple minute digitate hyper ker atoses (M M DH) is r epor ted. Hundr eds of spiked and ker atotic papules wer e distr ibuted on tr unk, axilae and limbs, with no palmoplantar or hair follicule affection. Histologically these lesions showed hyper ker atosis or thoker atotic. M M DH has thr ee clinical pr esentation: familial, spor adic and postinflammator y. All gr oups ar e clinically indistinguishable but histologically some impor tant differ ences exist between familial or spor adic type and postinflammator y type.
Contact …, Jan 1, 2004
... observe a rare bird. FS01.4 Hailey Hailey disease a significant hazard to consider when pat... more ... observe a rare bird. FS01.4 Hailey Hailey disease a significant hazard to consider when patch testing S Walker, Jason Williams, JO'Driscoll, M Beck Dermatology Centre, University of Manchester, Manchester, UK A 42 year old ...
Psychiatric Quarterly, 2017