Dr.K.Ranjith Babu | Vinayaka Missions's University (original) (raw)
Papers by Dr.K.Ranjith Babu
Annals of Human Genetics, 2011
SummaryPublished data on the association between the methylenetetrahydrofolate reductase (MTHFR) ... more SummaryPublished data on the association between the methylenetetrahydrofolate reductase (MTHFR) gene A1298C (rs1801131) polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta‐analysis was performed. In this meta‐analysis, a total of seven case‐control studies including 1633 cases and 1735 controls were selected to evaluate the possible association. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele‐frequency genetic model. In the overall analysis, the frequency of the C1298 allele (C vs. A) was significantly associated with susceptibility to male infertility (OR = 1.12, 95% CI = 1.00–1.26). A subgroup analysis of the subjects showed that MTHFR 1298C was associated with significant increased risk of azoospermia in homozygote comparison (CC vs. AA) and recessive mode (CC vs. AA/AC) (OR = 1.66 for ...
International journal of scientific research, Jun 1, 2015
Background & Objectives: Harvard step test has been given much attention to select highly physica... more Background & Objectives: Harvard step test has been given much attention to select highly physically active persons who will be capable of doing hard work so that they may be recruited in various sports & games or appropriate industrial occupations. The present study was carried out in medical students to determine the Harvard Step Test (HST). There is significant difference in Harvard Index (HI) or Physical Fitness Index (PFI) in male and female students because males are generally more aggressive and accepts challenges more than females, also there is significant difference in Height (Ht) and Weight (Wt) in males and females. So, PFI affected by body size as evidenced in the co-relation PFI with height and weight. Methods: The study was conducted in department of physiology, MNR Medical College, Sangareddy. A total of 133 subjects were selected, of whom 73 were male and 60 were female medical students whose age varied from 17 to 19 years. The subjects selected for this study were medical students admitted for First MBBS Course. The PFI or HI of the subjects was calculated by asking the subject to perform Harvard Step test. Prior to the test, age (Yrs), height (cm) and weight (kg) were recorded. Results: In the present study, the mean Harvard Index or PFI was 83.0101 in males and 60.2425 in females. Mean values of height and weight were 170.5603cms & 56.3219kgs in males and 156.14cms & 49.2Kgs in females respectively. Interpretation & Conclusion: Low mean value of PFI in female subjects compared to male subjects can thus be attributable to their lower body weight and height; also, males are generally more aggressive and accept challenges more than females. This present study is an attempt to modify Harvard step test with classification of score. But for Indians it is necessary to modify the step test because of short stature.
International journal of scientific research, 2018
INTRODUCTION: Hepatitis B virus (HBV) is responsible for the most frequent chronic liver disease ... more INTRODUCTION: Hepatitis B virus (HBV) is responsible for the most frequent chronic liver disease of infectious origin in human beings with chronically infected individuals worldwide. Chronic hepatitis B results in more than 6,00,000 deaths annually from the complications of end-stage liver disease and hepatocellular carcinoma (HCC). Detection of HBsAg is the most commonly used test for diagnosing acute HBV infections as well as for detecting carriers Immunochromatography assays (ICA) are economical and do not require special instrumentation for analysis and have been recommended for routine use in clinical microbiology laboratories for detection of HBsAg. It is simple to perform, is designed to be read by eye and does not require any expensive apparatus. When compared with a commercially available HEPA card kit for the detection of the same markers, ELISA was shown to be more sensitive for the detection of HBsAg.
International journal of health sciences
As per the statement by World Health Organization, Infertility is presence of a medical condition... more As per the statement by World Health Organization, Infertility is presence of a medical condition of the couple with inability in getting conceived for 1 year or more without usage of any contraception. In the present situation, the incidence of Infertility has increased and it is viewed as a major concern with affecting about 15% to 20% of the couples. A detailed systematic examination of history, investigative protocol is necessary for proper management of infertility. The patients were also advised for blood hormonal analysis tests such as Follicle Stimulation Hormone (FSH), Testosterone, Luteinizing Hormone (LH), Prolactin. Methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the key enzymes in folate metabolism. The enzyme activities of MTHFR and MTRR are influenced by gene polymorphisms. So the polymorphisms of MTHFR and MTRR may be a potential risk factor for male infertility. The present study was done in 100 males, 50 diabetic infertile ...
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2023
Alternanthera sessilis is a herb, growing upto 0.2 to 1 meter high with support of strong taproot... more Alternanthera sessilis is a herb, growing upto 0.2 to 1 meter high with support of strong taproots. The leaves grow at opposite sides. It is shortly leafstalk or sessile and broadly subulate or spatulate to almost linear, 0.3 to 1 cm wide and 0.6 to 5 cm long. The inorescences are sessile, dense, silvery-white clusters of compressed spikes in the leaf axils. The plant has attenuated base, crusty apex and glossy margins. Seeds are dark brown to black disc shaped, glossy and about 0.8 to 1 mm in diameter (1). Alternanthera sessilis bouillon is recommended for vomiting, bronchitis, nausea, wounds and diarrhoea. In combination with other plants, it is helpful in the treatment of asthma, hepatitis, bronchitis, tight chest and other lung defects. A. Sessilis roots are useful in relieving inamed wounds and hypertension (11). Propagation: In India and south Asian countries, the plant is used as remedy for headache, severe pain, low sperm count, leucorrhoea, hepatitis, asthma and other lung diseases. In India and Bangladesh, Alternanthera sessilis is well known for its medicinal properties (2).
International journal of health sciences
World Health Organization has stated Infertility as a medical condition in which an individual ha... more World Health Organization has stated Infertility as a medical condition in which an individual has the inability to conceive even after one year of regular unprotected active sexual intercourse. Presently, Infertility has been a major condition, which is multifactorial in nature and is supposed to have been affected approximately about 15% to 20% of the couples who are desperate for pregnancy. The contributory factors for male infertility may be of different factors comprising of complex pathogenesis, change in lifestyle, other organic diseases, genetic factors, environmental risk factors and their interactions. The patients with subnormal semen parameters are advised for blood hormonal analysis tests as these hormonal tests are more reliable and valid in the further proper management of the infertility [11]. These hormonal tests include Follicle Stimulation Hormone (FSH), Testosterone, Luteinizing Hormone (LH), Prolactin. This cross section study was done in 100 males, 50 diabetic ...
Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Feder... more Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu ...
Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Feder... more Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu ...
Background: Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR)are th... more Background: Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR)are the inflammatory markers in Type 2 Diabetes Mellitus (T2DM) and there are few documented Indian rural studies. The aim of this study is to evaluate the relationship between Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) with glycemic status (HbA1c) and duration of diabetic detection in rural Indian T2DM. Methods: This is a prospective observation study, T2DM between the ages of 30-60 years, attending to Sree Sidhi Vinayaka Diabetic Centre (2013-2019). NLR, PLR was compared with duration of diabetes and glycemic status. T2DM were divided into three groups, Group I with HbA1c <7[excellent control], Group II with HbA1c 7.01-9.0% [poor control] and Group III HbA1c >9 [worst control]. Results: 5163 patients attended the clinic, among them, 1303 fulfilled the inclusion criteria. The mean age of T2DM was 47.02±7.81 yrs, with 637 females and 666 males (Male: Female ratio ...
Indian Journal of Clinical Anatomy and Physiology, 2022
Hypertension(HTN) is the most common and significant cardiovascular disease because of its preval... more Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occ...
International Surgery Journal, 2019
Background: Thyroid gland diseases are common in India, particularly hilly and tribal areas. The ... more Background: Thyroid gland diseases are common in India, particularly hilly and tribal areas. The incidence of thyroid conditions, exact figure is not available but about 5 lakh cases come for Medical Treatment all over India. To study the prevalence of common thyroid diseases in the Sangareddy district area, which is near Hyderabad, particularly age & sex specific incidence.Methods: This is a retrospective study conducted at the Maheshwara Medical College and Hospital, Chitkul, Sangareddy district of Telangana State. The data was collected from the registers of General Surgery outpatient department, operation theatre, medical record section and cytology, histopathology registers of pathology department. A total number of 64 patients were included in this study who was admitted at this hospital during the period of 2 years, from January 2017 to December 2018. The data was analysed by proper statistical methods.Results: The study had shown that most common conditions in this area are ...
International Journal of Biomedical and Advance Research, 2017
Introduction: Diabetes is a Metabolic Disorder which has got prime focus in the present days. An ... more Introduction: Diabetes is a Metabolic Disorder which has got prime focus in the present days. An increase in body fat is generally associated with an increase in risk of metabolic diseases such as type 2 diabetes mellitus, hypertension and dyslipidaemia. Prevalence of childhood and adolescent obesity is further adding the severity. Therefore, any measures that could prevent or delay the development of diabetes are urgently needed. The present study is focused on early detection of the occurrence of Diabetes so that its control can be more effective because of early intervention. Materials & Methods: 50 people with increased blood sugar levels of age group of 16-20 years of both the sexes are selected randomly as subjects and 50 people with normal blood sugar levels are randomly selected as control group . Primary data of all the subjects like name, age, sex, occupation, address etc., are obtained as per the proforma. Calculation of Body Fat Percentage (%BF) involves measuring of ski...
Introduction: Because of increased awareness towards health, the importance of avoiding fat and s... more Introduction: Because of increased awareness towards health, the importance of avoiding fat and staying fit is increasing day by day. To assess the pulmonary function of an individual, Peak Expiratory Flow Rate (PEFR) is preferred because it is simple and reliable diagnostic and prognostic test. PEFR is preferred among other pulmonary functions tests because of the advantages like low cost of instrument (Wright’s flow meter), easy to explain the procedure even to the illiterates, easy to use and handle, easy to take the reading. Material & Methods: 150 healthy adults were selected after obtaining informed consent which includes 68 male and 82 female students of Viswabharathi medical college, Kurnool, Andhra Pradesh. The study was conducted in the Department of Physiology, Viswabharathi Medical College, Kurnool, Andhra Pradesh after obtaining ethical clearance from Institutional Ethical Committee. All the subjects are informed about the procedure and an individual demonstration about...
DOI: 10.21276/sjams.2018.6.9.66 Abstract:Hormones are one of the principal factors in intercellul... more DOI: 10.21276/sjams.2018.6.9.66 Abstract:Hormones are one of the principal factors in intercellular and inter-organ communication. The thyroid hormones are crucial for normal functioning because of their control over body’s basal metabolic rate, as well as growth, development, and differentiation of many cells/organs in the body.The present study was based on a crosssectional study design carried out at the outpatient department of Maheshwara Medical College & Hospital from January 2017 to July 2018. Serum levels of free thyroxin (FT4), thyroid stimulating hormone (TSH), free testosterone, prolactin (PRL), folliclestimulating hormone (FSH), and luteinizing hormone (LH) were measured using immunoassay commercial kits in both groups. The normal reference ranges for thyroid hormones were as follows: TSH, 0.3 to 5.0 IU/mL and T4, 4.5 to 12.5 g/dL. Erectile dysfunction was evaluated using International Index of Erectile Function (IIEF-5) questionnaire. The results were averaged as (mean ...
International Journal of Advances in Scientific Research, Aug 30, 2015
Introduction: Smoking is one of the most ancient and widespread man"s activities. The present stu... more Introduction: Smoking is one of the most ancient and widespread man"s activities. The present study was chosen to determine sympathetic and parasympathetic activity in cigarette smokers and compare it with healthy age matched controls in order to find out what influence does smoking have on baroreceptor sympathetic and parasympathetic control mechanisms and to find out for any co-relation between duration of cigarette smoking and autonomic dysfunction. Materials & Methods: Fifty cigarette smokers and fifty normal, healthy, nonsmokers were selected as age matched controls to study autonomic functions. Sympathetic functions were carried out by Cold Pressor Response test and Hand Grip test. Parasympathetic functions were tested by Determination of Heart Rate with change in posture and Sinus Arrhythmia. Results: Smokers revealed more pronounced rise both in systolic as well as diastolic blood pressure as compared to normal healthy controls during cold pressor test. Smokers revealed more pronounced rise in both SBP and DBP as compared to nonsmokers during hand grip test. There was increased heart rate in initial 10 seconds when there is postural change i.e. lying down to standing in both the groups. There was an increase in heart rate during inspiration and decrease during expiration (sinus arrhythmia) both in smokers and healthy controls. Conclusion: Cigarette smoking affects cardiovascular functions as indicated by rise in blood pressure in smokers than nonsmokers reflects the sensitivity of sympathetic activity to nicotine due to smoking. Thus the study concludes that smoking possibly has an effect on neurocardiovascular regulation system altering the sensitivity of ANS activity in habitual smokers.
International Journal of Biomedical Research, 2015
Background: Hypertension is the major health problem throughout the world because of its high pre... more Background: Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. Aim: The aim of present study was to evaluate the hematological changes in primary hypertension in Sangareddy, Andhra Pradesh. Materials and Methods: In the present study, a total of 100 patients diagnosed for primary hypertension and 100 normotensive subjects were included. All the participants after taking informed consent were subjected to detailed history and hematological analysis. Students-'t' test was used to find out the significance of differences. P values less than 0.05 was considered the level of significance. Result: It was observed that the mean values of Hemoglobin, Erythrocyte count, Hematocrit, MCH and MCHC were increased in primary hypertension while, the mean levels of MCV were found to be lower in the hypertensive group when compared to normotensive subjects. Conclusion: Hypertension has impact on hematocrit, hemoglobin, RBC count, WBC count and Platelet count which can be used for early detection of hypertensive prone individuals.
Annals of Human Genetics, 2011
SummaryPublished data on the association between the methylenetetrahydrofolate reductase (MTHFR) ... more SummaryPublished data on the association between the methylenetetrahydrofolate reductase (MTHFR) gene A1298C (rs1801131) polymorphism and male infertility risk are inconclusive. To derive a more precise estimation of the relationship, a meta‐analysis was performed. In this meta‐analysis, a total of seven case‐control studies including 1633 cases and 1735 controls were selected to evaluate the possible association. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the additive model, dominant model, recessive model, and allele‐frequency genetic model. In the overall analysis, the frequency of the C1298 allele (C vs. A) was significantly associated with susceptibility to male infertility (OR = 1.12, 95% CI = 1.00–1.26). A subgroup analysis of the subjects showed that MTHFR 1298C was associated with significant increased risk of azoospermia in homozygote comparison (CC vs. AA) and recessive mode (CC vs. AA/AC) (OR = 1.66 for ...
International journal of scientific research, Jun 1, 2015
Background & Objectives: Harvard step test has been given much attention to select highly physica... more Background & Objectives: Harvard step test has been given much attention to select highly physically active persons who will be capable of doing hard work so that they may be recruited in various sports & games or appropriate industrial occupations. The present study was carried out in medical students to determine the Harvard Step Test (HST). There is significant difference in Harvard Index (HI) or Physical Fitness Index (PFI) in male and female students because males are generally more aggressive and accepts challenges more than females, also there is significant difference in Height (Ht) and Weight (Wt) in males and females. So, PFI affected by body size as evidenced in the co-relation PFI with height and weight. Methods: The study was conducted in department of physiology, MNR Medical College, Sangareddy. A total of 133 subjects were selected, of whom 73 were male and 60 were female medical students whose age varied from 17 to 19 years. The subjects selected for this study were medical students admitted for First MBBS Course. The PFI or HI of the subjects was calculated by asking the subject to perform Harvard Step test. Prior to the test, age (Yrs), height (cm) and weight (kg) were recorded. Results: In the present study, the mean Harvard Index or PFI was 83.0101 in males and 60.2425 in females. Mean values of height and weight were 170.5603cms & 56.3219kgs in males and 156.14cms & 49.2Kgs in females respectively. Interpretation & Conclusion: Low mean value of PFI in female subjects compared to male subjects can thus be attributable to their lower body weight and height; also, males are generally more aggressive and accept challenges more than females. This present study is an attempt to modify Harvard step test with classification of score. But for Indians it is necessary to modify the step test because of short stature.
International journal of scientific research, 2018
INTRODUCTION: Hepatitis B virus (HBV) is responsible for the most frequent chronic liver disease ... more INTRODUCTION: Hepatitis B virus (HBV) is responsible for the most frequent chronic liver disease of infectious origin in human beings with chronically infected individuals worldwide. Chronic hepatitis B results in more than 6,00,000 deaths annually from the complications of end-stage liver disease and hepatocellular carcinoma (HCC). Detection of HBsAg is the most commonly used test for diagnosing acute HBV infections as well as for detecting carriers Immunochromatography assays (ICA) are economical and do not require special instrumentation for analysis and have been recommended for routine use in clinical microbiology laboratories for detection of HBsAg. It is simple to perform, is designed to be read by eye and does not require any expensive apparatus. When compared with a commercially available HEPA card kit for the detection of the same markers, ELISA was shown to be more sensitive for the detection of HBsAg.
International journal of health sciences
As per the statement by World Health Organization, Infertility is presence of a medical condition... more As per the statement by World Health Organization, Infertility is presence of a medical condition of the couple with inability in getting conceived for 1 year or more without usage of any contraception. In the present situation, the incidence of Infertility has increased and it is viewed as a major concern with affecting about 15% to 20% of the couples. A detailed systematic examination of history, investigative protocol is necessary for proper management of infertility. The patients were also advised for blood hormonal analysis tests such as Follicle Stimulation Hormone (FSH), Testosterone, Luteinizing Hormone (LH), Prolactin. Methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the key enzymes in folate metabolism. The enzyme activities of MTHFR and MTRR are influenced by gene polymorphisms. So the polymorphisms of MTHFR and MTRR may be a potential risk factor for male infertility. The present study was done in 100 males, 50 diabetic infertile ...
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, 2023
Alternanthera sessilis is a herb, growing upto 0.2 to 1 meter high with support of strong taproot... more Alternanthera sessilis is a herb, growing upto 0.2 to 1 meter high with support of strong taproots. The leaves grow at opposite sides. It is shortly leafstalk or sessile and broadly subulate or spatulate to almost linear, 0.3 to 1 cm wide and 0.6 to 5 cm long. The inorescences are sessile, dense, silvery-white clusters of compressed spikes in the leaf axils. The plant has attenuated base, crusty apex and glossy margins. Seeds are dark brown to black disc shaped, glossy and about 0.8 to 1 mm in diameter (1). Alternanthera sessilis bouillon is recommended for vomiting, bronchitis, nausea, wounds and diarrhoea. In combination with other plants, it is helpful in the treatment of asthma, hepatitis, bronchitis, tight chest and other lung defects. A. Sessilis roots are useful in relieving inamed wounds and hypertension (11). Propagation: In India and south Asian countries, the plant is used as remedy for headache, severe pain, low sperm count, leucorrhoea, hepatitis, asthma and other lung diseases. In India and Bangladesh, Alternanthera sessilis is well known for its medicinal properties (2).
International journal of health sciences
World Health Organization has stated Infertility as a medical condition in which an individual ha... more World Health Organization has stated Infertility as a medical condition in which an individual has the inability to conceive even after one year of regular unprotected active sexual intercourse. Presently, Infertility has been a major condition, which is multifactorial in nature and is supposed to have been affected approximately about 15% to 20% of the couples who are desperate for pregnancy. The contributory factors for male infertility may be of different factors comprising of complex pathogenesis, change in lifestyle, other organic diseases, genetic factors, environmental risk factors and their interactions. The patients with subnormal semen parameters are advised for blood hormonal analysis tests as these hormonal tests are more reliable and valid in the further proper management of the infertility [11]. These hormonal tests include Follicle Stimulation Hormone (FSH), Testosterone, Luteinizing Hormone (LH), Prolactin. This cross section study was done in 100 males, 50 diabetic ...
Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Feder... more Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu ...
Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Feder... more Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu ...
Background: Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR)are th... more Background: Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR)are the inflammatory markers in Type 2 Diabetes Mellitus (T2DM) and there are few documented Indian rural studies. The aim of this study is to evaluate the relationship between Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR) with glycemic status (HbA1c) and duration of diabetic detection in rural Indian T2DM. Methods: This is a prospective observation study, T2DM between the ages of 30-60 years, attending to Sree Sidhi Vinayaka Diabetic Centre (2013-2019). NLR, PLR was compared with duration of diabetes and glycemic status. T2DM were divided into three groups, Group I with HbA1c <7[excellent control], Group II with HbA1c 7.01-9.0% [poor control] and Group III HbA1c >9 [worst control]. Results: 5163 patients attended the clinic, among them, 1303 fulfilled the inclusion criteria. The mean age of T2DM was 47.02±7.81 yrs, with 637 females and 666 males (Male: Female ratio ...
Indian Journal of Clinical Anatomy and Physiology, 2022
Hypertension(HTN) is the most common and significant cardiovascular disease because of its preval... more Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occ...
International Surgery Journal, 2019
Background: Thyroid gland diseases are common in India, particularly hilly and tribal areas. The ... more Background: Thyroid gland diseases are common in India, particularly hilly and tribal areas. The incidence of thyroid conditions, exact figure is not available but about 5 lakh cases come for Medical Treatment all over India. To study the prevalence of common thyroid diseases in the Sangareddy district area, which is near Hyderabad, particularly age & sex specific incidence.Methods: This is a retrospective study conducted at the Maheshwara Medical College and Hospital, Chitkul, Sangareddy district of Telangana State. The data was collected from the registers of General Surgery outpatient department, operation theatre, medical record section and cytology, histopathology registers of pathology department. A total number of 64 patients were included in this study who was admitted at this hospital during the period of 2 years, from January 2017 to December 2018. The data was analysed by proper statistical methods.Results: The study had shown that most common conditions in this area are ...
International Journal of Biomedical and Advance Research, 2017
Introduction: Diabetes is a Metabolic Disorder which has got prime focus in the present days. An ... more Introduction: Diabetes is a Metabolic Disorder which has got prime focus in the present days. An increase in body fat is generally associated with an increase in risk of metabolic diseases such as type 2 diabetes mellitus, hypertension and dyslipidaemia. Prevalence of childhood and adolescent obesity is further adding the severity. Therefore, any measures that could prevent or delay the development of diabetes are urgently needed. The present study is focused on early detection of the occurrence of Diabetes so that its control can be more effective because of early intervention. Materials & Methods: 50 people with increased blood sugar levels of age group of 16-20 years of both the sexes are selected randomly as subjects and 50 people with normal blood sugar levels are randomly selected as control group . Primary data of all the subjects like name, age, sex, occupation, address etc., are obtained as per the proforma. Calculation of Body Fat Percentage (%BF) involves measuring of ski...
Introduction: Because of increased awareness towards health, the importance of avoiding fat and s... more Introduction: Because of increased awareness towards health, the importance of avoiding fat and staying fit is increasing day by day. To assess the pulmonary function of an individual, Peak Expiratory Flow Rate (PEFR) is preferred because it is simple and reliable diagnostic and prognostic test. PEFR is preferred among other pulmonary functions tests because of the advantages like low cost of instrument (Wright’s flow meter), easy to explain the procedure even to the illiterates, easy to use and handle, easy to take the reading. Material & Methods: 150 healthy adults were selected after obtaining informed consent which includes 68 male and 82 female students of Viswabharathi medical college, Kurnool, Andhra Pradesh. The study was conducted in the Department of Physiology, Viswabharathi Medical College, Kurnool, Andhra Pradesh after obtaining ethical clearance from Institutional Ethical Committee. All the subjects are informed about the procedure and an individual demonstration about...
DOI: 10.21276/sjams.2018.6.9.66 Abstract:Hormones are one of the principal factors in intercellul... more DOI: 10.21276/sjams.2018.6.9.66 Abstract:Hormones are one of the principal factors in intercellular and inter-organ communication. The thyroid hormones are crucial for normal functioning because of their control over body’s basal metabolic rate, as well as growth, development, and differentiation of many cells/organs in the body.The present study was based on a crosssectional study design carried out at the outpatient department of Maheshwara Medical College & Hospital from January 2017 to July 2018. Serum levels of free thyroxin (FT4), thyroid stimulating hormone (TSH), free testosterone, prolactin (PRL), folliclestimulating hormone (FSH), and luteinizing hormone (LH) were measured using immunoassay commercial kits in both groups. The normal reference ranges for thyroid hormones were as follows: TSH, 0.3 to 5.0 IU/mL and T4, 4.5 to 12.5 g/dL. Erectile dysfunction was evaluated using International Index of Erectile Function (IIEF-5) questionnaire. The results were averaged as (mean ...
International Journal of Advances in Scientific Research, Aug 30, 2015
Introduction: Smoking is one of the most ancient and widespread man"s activities. The present stu... more Introduction: Smoking is one of the most ancient and widespread man"s activities. The present study was chosen to determine sympathetic and parasympathetic activity in cigarette smokers and compare it with healthy age matched controls in order to find out what influence does smoking have on baroreceptor sympathetic and parasympathetic control mechanisms and to find out for any co-relation between duration of cigarette smoking and autonomic dysfunction. Materials & Methods: Fifty cigarette smokers and fifty normal, healthy, nonsmokers were selected as age matched controls to study autonomic functions. Sympathetic functions were carried out by Cold Pressor Response test and Hand Grip test. Parasympathetic functions were tested by Determination of Heart Rate with change in posture and Sinus Arrhythmia. Results: Smokers revealed more pronounced rise both in systolic as well as diastolic blood pressure as compared to normal healthy controls during cold pressor test. Smokers revealed more pronounced rise in both SBP and DBP as compared to nonsmokers during hand grip test. There was increased heart rate in initial 10 seconds when there is postural change i.e. lying down to standing in both the groups. There was an increase in heart rate during inspiration and decrease during expiration (sinus arrhythmia) both in smokers and healthy controls. Conclusion: Cigarette smoking affects cardiovascular functions as indicated by rise in blood pressure in smokers than nonsmokers reflects the sensitivity of sympathetic activity to nicotine due to smoking. Thus the study concludes that smoking possibly has an effect on neurocardiovascular regulation system altering the sensitivity of ANS activity in habitual smokers.
International Journal of Biomedical Research, 2015
Background: Hypertension is the major health problem throughout the world because of its high pre... more Background: Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. Aim: The aim of present study was to evaluate the hematological changes in primary hypertension in Sangareddy, Andhra Pradesh. Materials and Methods: In the present study, a total of 100 patients diagnosed for primary hypertension and 100 normotensive subjects were included. All the participants after taking informed consent were subjected to detailed history and hematological analysis. Students-'t' test was used to find out the significance of differences. P values less than 0.05 was considered the level of significance. Result: It was observed that the mean values of Hemoglobin, Erythrocyte count, Hematocrit, MCH and MCHC were increased in primary hypertension while, the mean levels of MCV were found to be lower in the hypertensive group when compared to normotensive subjects. Conclusion: Hypertension has impact on hematocrit, hemoglobin, RBC count, WBC count and Platelet count which can be used for early detection of hypertensive prone individuals.