Involvement of monoaminergic system in the antidepressant-like effect of riparin I fromAniba riparia(Nees) Mez (Lauraceae) in mice (original) (raw)
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Pharmacology Biochemistry and Behavior, 1996
O'NEILL, M. F., A. Cl. FERNANDEZ AND J. M. PALACIOS. CR 127935 blocks the locomotor and antidepressantlike effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. PHARMACOL BIOCHEM BEHAV 53(3) 535-539,1996.-The 5-HT ,A,B agonist RU 24969 induces hyperactivity in rodents and also shows antidepmssantlike effects in some animal models of depression. We have examined the effects of selective antagonists at 5-HT,, and 5-HT,, receptors (WAY 100135 and GR 127935, respectively) on both the hyperlocomotor and anti-immobility effects of RU 24969.
Our previous study described the synthesis of 4-amine derivatives of 10,11-dihydro-5H-dibenzo-alkylamine-cycloheptane, 4-amine (3-N,N-dimethylpropylamine)-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5-one (ADDCH1), and 1,2,3,4,8,9-hexahydro-dibenzocycloheptane[4,4a,5-ef]1,4-diazepin (ADDCH2), and the characterization of their antidepressant-like effect in the forced swimming test in mice. This study investigated the involvement of monoaminergic pathways in the antidepressant-like effect of these compounds in mice evaluated in the tail suspension test (TST), another animal model to screen antidepressant drugs. Our results show that the immobility time in the TSTwas significantly reduced by ADDCH1 (15 to 50 mg/kg, i.p.) or ADDCH2 (30 and 50 mg/kg, i.p.). The antidepressant-like effect of ADDCH1 (30 mg/kg, i.p.) in the TST was prevented by pre-treatment of mice with methysergide (2 mg/kg, i.p.), a non-selective serotonin receptor antagonist, p-chlorophenylalanine methylester (pCPA, 100 mg/kg, i.p.), an inhibitor of serotonin synthesis, prazosin (62.5 μg/kg, i.p.), an α 1-adrenoceptor antagonist, or yohimbine (1 mg/kg, i.p.), an α 2-adrenoceptor antagonist. In contrast, the antidepressant-like effect of ADDCH2 was antagonized only by yohimbine (1 mg/kg) or haloperidol (50 μg/kg, i.p.), a dopamine D 2 /D 3 /D 4 receptor antagonist, and was not affected by methysergide, pCPA or prazosin. Altogether, the present results strongly suggest the differential involvement of monoaminergic systems, serotonin/noradrenaline (ADDCH1) and noradrenaline/dopamine (ADDCH2) pathways, respectively, in the antidepressant-like effect of dibenzosuberone compounds.
Biological & Pharmaceutical Bulletin, 2006
Aniba is a genus that comprises 41 species of shrubs and trees and is primarily a lowland group with its centre of diversity in Central Amazonia and Guiana. However, this genus extends into the Andes, the mountains of northern Venezuela, the lesses Antilles and eastern and southern Brazil. One of its species, Aniba riparia (NEES) MEZ, from the Lauraceae family, is popularly known as "louro" in Brazil and occurs in the Humaitá region of the Amazonas state of Brazil. 1) From the unripe fruit of Aniba riparia, collected from the Amazonas state of Brazil, were isolated three substances with broad spectrum antimicrobial activity: methyl ethers of N-(benzoyl) tyramine (riparin I), N-(2-hydroxybenzoyl) tyramine (riparin II) and N-(2,6-dihydroxybenzoyl) tyramine (riparin III) 2) ( ) which were later synthesized. It was reported that one of the above compounds, (Omethyl)-N-(2,6-dihydroxybenzoyl) tyramine (riparin III), has potent smooth muscle relaxant activity. 5,6) Thus, in concentrations from 8 to 30 mM, riparin III antagonized acetylcholine-and histamine-induced contractions of guinea-pig ileum, and oxytocin-and bradykinin-induced contractions of the rat uterus. Further, in the guinea-pig trachea, riparin III inhibited the spontaneous tone (IC 50 7.7 mM) and carbacholinduced contractions (IC 50 10 mM). The spasmolytic effect of riparin III, was investigated 7) concerning the involvement of the compound in relation to Ca 2ϩ metabolism. It was demonstrated that riparin III produces an inhibition of Ca 2ϩ influx and release of intracellular Ca 2ϩ . These results lead to the reduction of intracellular Ca 2ϩ concentration and possibly contribute to the drug spasmolytic effect.
Progress in Neuro- …, 2008
Our previous study described the synthesis of 4-amine derivatives of 10,11-dihydro-5H-dibenzo-alkylamine-cycloheptane, 4-amine (3-N,Ndimethylpropylamine)-10,11-dihydro-5H-dibenzo[a,d] cycloheptane-5-one (ADDCH1), and 1,2,3,4,8,9-hexahydro-dibenzocycloheptane[4,4a,5-ef]1,4diazepin (ADDCH2), and the characterization of their antidepressant-like effect in the forced swimming test in mice. This study investigated the involvement of monoaminergic pathways in the antidepressant-like effect of these compounds in mice evaluated in the tail suspension test (TST), another animal model to screen antidepressant drugs. Our results show that the immobility time in the TSTwas significantly reduced by ADDCH1 (15 to 50 mg/kg, i.p.) or ADDCH2 (30 and 50 mg/kg, i.p.). The antidepressant-like effect of ADDCH1 (30 mg/kg, i.p.) in the TST was prevented by pre-treatment of mice with methysergide (2 mg/kg, i.p.), a non-selective serotonin receptor antagonist, p-chlorophenylalanine methylester (pCPA, 100 mg/kg, i.p.), an inhibitor of serotonin synthesis, prazosin (62.5 μg/kg, i.p.), an α 1-adrenoceptor antagonist, or yohimbine (1 mg/kg, i.p.), an α 2-adrenoceptor antagonist. In contrast, the antidepressant-like effect of ADDCH2 was antagonized only by yohimbine (1 mg/kg) or haloperidol (50 μg/kg, i.p.), a dopamine D 2 /D 3 /D 4 receptor antagonist, and was not affected by methysergide, pCPA or prazosin. Altogether, the present results strongly suggest the differential involvement of monoaminergic systems, serotonin/noradrenaline (ADDCH1) and noradrenaline/dopamine (ADDCH2) pathways, respectively, in the antidepressant-like effect of dibenzosuberone compounds.
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009
Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including depression. In this study, the effect of the hydroalcoholic extract of the stems and leaves of this plant was investigated in two behavioral models, the forced swimming test (FST) and tail suspension test (TST) in mice. The extract of R. officinalis produced an antidepressant-like effect, since the acute treatment of mice with the extract by p.o. route significantly reduced the immobility time in the FST (100 mg/kg) and TST (10-100 mg/kg), as compared to a control group, without accompanying changes in ambulation in the open-field test. Moreover, the repeated administration (14 days) of the hydroalcoholic extract of R. officinalis by p.o. route also produced an antidepressant-like effect in the TST (100-300 mg/kg). The pretreatment of mice with p-chlorophenylalanine (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, for 4 consecutive days), NAN-190 (0.5 mg/kg, i.p., a 5-HT 1A receptor antagonist), ketanserin (5 mg/kg, i.p., a 5-HT 2A receptor antagonist), 1-(m-chlorophenyl) biguanide (mCPBG, 10 mg/kg, i.p., a 5-HT 3 receptor agonist), prazosin (1 mg/kg, i.p., an α 1-adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D 1 receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D 2 receptor antagonist), but not yohimbine (1 mg/kg, i.p., an α 2-adrenoceptor antagonist) was able to reverse the antiimmobility effect of the extract (10 mg/kg, p.o.) in the TST. The combination of MDL72222, (0.1 mg/kg, i.p., a 5-HT 3 receptor antagonist) with a sub-effective dose of the extract of R. officinalis (1 mg/kg, p.o.) produced an anti-immobility effect in the TST. The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.
European Journal of Pharmacology, 2007
A large body of evidence corroborates the notion that deficiencies of serotonergic system are likely involved in the pathogenesis of both depression and anxiety. Activation of β 3 adrenoceptors has been shown to increase brain tryptophan content suggesting an elevation of brain serotonin (5HT) synthesis. SR58611A is a selective β 3 adrenergic agent possessing a profile of antidepressant activity in routine rodents' experimental models of depression. The present study was undertaken to evaluate in rodents the antidepressant properties of SR58611A and to assess its putative anxiolytic value in experimental models of depression and anxiety. Compared to the control group, SR58611A (0.1, 1, 5 or 10 mg/kg) caused a dose-dependent reduction in immobility of Wistar male rats in the forced swim test. The maximum dose appeared to be equivalent to an effective dose of clomipramine (50 mg/kg). In addition, acute injection of SR58611A induced in rats a dose-dependent decrease in grooming response to a novel environment (novelty-induced grooming test). For any dose, the effect was lower than that of diazepam (1 mg/kg). Chronic treatment with SR58611A resulted also in an increased social interaction time in the social interaction test without affecting motor activity of rats. Furthermore, similarly to diazepam a chronic treatment with the highest doses of SR58611A was followed by increased exploratory behavior in Swiss male mice exposed to the elevated plus maze test. These effects are mediated by β 3 adrenoceptors since i.p. pretreatment with the selective β 3 adrenoceptor antagonist SR59230A (5 mg/kg) blocked the effects of SR58611A. Finally, also the 5HT antagonist methysergide (2 mg/kg) prevented the antidepressant and anxiolytic-like activity of SR58611A indicating that 5HT transmission is strictly involved in its action.
European Journal of Medicinal Plants, 2020
Rauwolfia vomitoria is one of the medicinal plants which is used traditionally to manage hypertension, diabetes and mental disorder. The scientific evidence to suggest its medicinal use especially in mental health treatment is lacking. This study aimed to investigate the antidepressant-like effect of the leaf and root extracts of R. vomitoria in the rat model using neurobehavioural indices; open field test and forced swimming test. Subsequently, the effect of the extracts on monoamine neurotransmitters system was investigated. The neurobehavioral response of rats by open field test and forced swim test showed that there was a reduction in the explorative tendencies of the rats administered the aqueous and ethanol root extracts (125, 250, 500 mg/kg) compared to the control while forced swim test reduced the immobility time of rats across all treatment groups except 500 mg/kg group. Neurotransmitter levels (serotonin, dopamine and norepinephrine) in plasma and brain of rats administer...
Journal of Ethnopharmacology, 2013
Ethnopharmacological relevance: Aloysia gratissima (Verbenaceae) is an aromatic plant distributed in South America and, employed in folk medicine for the treatment of nervous systems illness, including depression. The neuroprotective and antidepressant-like activities of the aqueous extract of Aloysia gratissima (AE) administered orally has already been demonstrated.In this study the involvement of monoaminergic systems in the antidepressant-like effect of the AE was investigated. Materials and methods: The implication of the monoaminergic systems in the antidepressant-like activity of Aloysia gratissima was evaluated using different pharmacological antagonists that were administered previously to the acute oral administration of AE (10 mg/kg). The antidepressant-like effect was assessed in the TST and locomotor activity was evaluated in the open-field test in mice. Results: The anti-immobility effect elicited by AE in the TST was prevented by the pre-treatment of mice with the antagonists, NAN-190 (5-HT 1A receptor), ketanserin (5-HT 2A/2C receptor), prazosin (α 1-adrenoceptor), yohimbine (α 2-adrenoceptor), SCH23390 (dopamine D 1 receptor), or sulpiride (dopamine D 2 receptor). Conclusions: These results indicate that the antidepressant-like effect of AE in the TST is dependent on its interaction with the serotonergic (5-HT 1A and 5-HT 2A/2C), noradrenergic (α 1 and α 2− adrenoceptors) and dopaminergic (D 1 and D 2 receptors) systems, suggesting that this specie might act as a new potential resource for developing antidepressants to treat depressive disorders.