Solitary neurofibroma of the larynx: a diagnostic challenge (original) (raw)
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Solitary fibrous tumor of the larynx: report of two new cases
Jornal Brasileiro de Patologia e Medicina Laboratorial, 2014
Solitary fibrous tumor is a rare neoplasm. Few cases have been described in the head and neck area, and less than 11 were located in the larynx. We described two new cases of solitary fibrous tumor of the larynx. A man, 64-year-old, and a woman, 77-year-old, both with submucosal and nodular supraglottic lesions, were submitted to surgical treatment and both showed CD-34 and bcl-2 immunoreactivity and S-100 and smooth-muscle actin negativity. After 24 and 22 months of postoperative follow-up, respectively, they did not show signs of active disease.
Solitary fibrous tumor of the larynx: Literature review and a case presentation
Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2016
Introduction: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, which is traditionally seen as a pleural mass, but can also occur in other locations. Although SFTs are very rare in the head and neck region, they have been reported in the orbit, nasal cavity, paranasal sinus, nasopharynx, parapharyngeal space, thyroid gland, and larynx. Laryngeal involvement has been previously reported in only 11 cases. Case report: The case is here presented of a 57-year-old male with complaints of progressive hoarseness and difficulty in breathing which had been ongoing for 1 year. By direct laryngoscopy the mass which was oriented from the right vocal cord was totally excised. Discussion: The clinical, radiological and histopathological findings are reported here, with a review of literature, to comprise the twelfth case of laryngeal solitary fibrous tumor.
Solitary fibrous tumor of the larynx: a case report and review of the literature
Archives of pathology & laboratory medicine, 2006
Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.
The Biology and Management of Laryngeal Neurofibroma
Archives of Otolaryngology–Head & Neck Surgery, 2004
Objectives: To review the presentation of laryngeal neurofibroma, including its association with neurofibromatosis types 1 and 2, and present guidelines for its management.
Solitary Fibrous Tumor of the Larynx
Otolaryngology-head and Neck Surgery, 2005
Background True mesenchymal, non-cartilaginous neoplasms of the larynx are rare. Extrapleural solitary fibrous tumor (SFT) is a localized neoplasm characterized by proliferation of thin-walled vessels and collagen-producing cells and is considered within the ''hemangiopericytoma-solitary fibrous tumor'' spectrum. SFT primary in the larynx is exceptional. Design Case report set in a comparison with other cases reported in the English literature (MEDLINE 1966(MEDLINE to 2007. Results A 49year old white male presented with difficulty breathing, progressive over the past 2 years. He denied dysphagia and weight loss. Past medical history was significant for asthma. He denied cigarette smoking or alcohol abuse. There were no cervical deformities on physical exam. Fiberoptic laryngoscopy was performed upon stabilization of respiratory function. A smooth, round, submucosal mass measuring 2.3 cm in greatest diameter arising from the inferior surface of left true vocal cord was causing near total obstruction of the endolaryngeal space. The mass was excised. The surface mucosa was intact and unremarkable. A cellular, spindle cell neoplasm was arranged in loose fascicles, associated with heavy collagen fiber deposition. The collagen was wiry and heavy. Cells were bland with cytoplasmic extensions. The nuclei were vesicular to hyperchromatic and elongated with inconspicuous nucleoli. Vessels were prominent and delicate, with patulous spaces. Mitotic figures were easily identified, but atypical forms were not present. The cells were strongly and diffusely immunoreactive with CD34 and bcl-2, while non-reactive with cytokeratin, EMA, actin, ALK-1, S100, desmin, and CD117. These findings confirmed a diagnosis of extraplural solitary fibrous tumor. Without further disease, the patient is alive without evidence of disease, 12 months after surgery. Conclusions The characteristic histologic pattern of solitary fibrous tumor can be noted in extrapulmonary locations. Development in the larynx is uncommon, but the tumor presents as a polypoid mass with characteristic histologic and immunophenotypic features. Conservative local excision is the treatment of choice to yield an excellent prognosis.
Solitary fibrous tumour of the larynx: A case report
European Annals of Otorhinolaryngology, Head and Neck Diseases, 2011
Introduction: Solitary fibrous tumour (SFT) of the larynx is a rare benign mesenchymal tumour of adults. The diagnosis is based on a combination of histological and immunohistochemical signs. Case report: The authors report the case of a patient with chronic laryngeal dysphonia and dyspnoea related to supraglottic SFT. Discussion/Conclusion: The main challenge of surgery is to ensure healthy resection margins to avoid recurrence while preserving the functions of the upper aerodigestive tract. Surgery is the treatment of choice and provides an excellent prognosis. Long-term clinical follow-up is required to detect rare recurrences.
Pediatric laryngeal neurofibroma: case report and review of the literature
International journal of pediatric otorhinolaryngology, 2014
Presentation of a case of pediatric laryngeal neurofibroma (LNF) and review of the world literature. Comprehensive review of the world literature using Pubmed and Google scholar. Pediatric LNF was identified in 62 cases reported in the world literature. The most common presenting symptom is stridor and the most common location of the tumor in the larynx is the aryepiglottic fold. Recent reports demonstrate increased utilization of endoscopic resection with reduced need for tracheostomy. Pediatric LNF is a rare disorder. Review of the world literature since 1940 suggests a recent trend away from aggressive open resection and toward more conservative endoscopic resection with excellent functional results.
Clinical Imaging, 2013
Although neurofibroma is a common soft tissue tumor of the head and neck, neurofibroma of the oropharynx is extremely rare. Here, we report a case of neurofibroma of the palatine tonsil. Magnetic resonance imaging was useful in demonstrating the location of the tumor as well as its well-defined appearance. The present case showed a target sign; the tumor exhibited peripheral hyperintensity and central hypointensity on T2-weighted images, reflecting its characteristic zonal anatomy.
Transoral approach to a huge neurofibroma of the parapharyngeal space: a case report
Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat, 2007
Neurofibroma of the parapharyngeal space accounts for less than 2% of all parapharyngeal space neoplasms. A 38-year-old man presented with complaints of snoring and left-sided nasal obstruction. Medical history also revealed numerous huge skin neurofibromas and multiple café au lait spots all over the body. Pharyngeal endoscopic examination disclosed a firm, nonpulsatile submucosal mass, pushing the left pharyngeal region approximately 5 cm medially, and extending to the inferior part of the epiglottis. The tumor was removed by transoral excision without any subsequent complications. Histological and immunohistochemical examinations revealed a neurofibroma.