Solitary fibrous tumour of the larynx: A case report (original) (raw)
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Solitary fibrous tumor of the larynx: Literature review and a case presentation
Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2016
Introduction: Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm, which is traditionally seen as a pleural mass, but can also occur in other locations. Although SFTs are very rare in the head and neck region, they have been reported in the orbit, nasal cavity, paranasal sinus, nasopharynx, parapharyngeal space, thyroid gland, and larynx. Laryngeal involvement has been previously reported in only 11 cases. Case report: The case is here presented of a 57-year-old male with complaints of progressive hoarseness and difficulty in breathing which had been ongoing for 1 year. By direct laryngoscopy the mass which was oriented from the right vocal cord was totally excised. Discussion: The clinical, radiological and histopathological findings are reported here, with a review of literature, to comprise the twelfth case of laryngeal solitary fibrous tumor.
Solitary fibrous tumor of the larynx: a case report and review of the literature
Archives of pathology & laboratory medicine, 2006
Solitary fibrous tumors are relatively rare mesenchymal neoplasms that were originally described as pleural- or peritoneal-based lesions. Although they were considered a form of mesothelioma, subsequent investigation failed to reveal mesothelial differentiation. Characterization of their histologic and immunohistochemical features, as well as identification in a multitude of nonmesothelial-based locations has further served to distinguish these lesions from the more diffuse and aggressive mesothelioma. Reports of solitary fibrous tumor in the larynx are extremely rare. We report a case of solitary fibrous tumor of the larynx in a 38-year-old man.
Solitary Fibrous Tumor of the Larynx
Otolaryngology-head and Neck Surgery, 2005
Background True mesenchymal, non-cartilaginous neoplasms of the larynx are rare. Extrapleural solitary fibrous tumor (SFT) is a localized neoplasm characterized by proliferation of thin-walled vessels and collagen-producing cells and is considered within the ''hemangiopericytoma-solitary fibrous tumor'' spectrum. SFT primary in the larynx is exceptional. Design Case report set in a comparison with other cases reported in the English literature (MEDLINE 1966(MEDLINE to 2007. Results A 49year old white male presented with difficulty breathing, progressive over the past 2 years. He denied dysphagia and weight loss. Past medical history was significant for asthma. He denied cigarette smoking or alcohol abuse. There were no cervical deformities on physical exam. Fiberoptic laryngoscopy was performed upon stabilization of respiratory function. A smooth, round, submucosal mass measuring 2.3 cm in greatest diameter arising from the inferior surface of left true vocal cord was causing near total obstruction of the endolaryngeal space. The mass was excised. The surface mucosa was intact and unremarkable. A cellular, spindle cell neoplasm was arranged in loose fascicles, associated with heavy collagen fiber deposition. The collagen was wiry and heavy. Cells were bland with cytoplasmic extensions. The nuclei were vesicular to hyperchromatic and elongated with inconspicuous nucleoli. Vessels were prominent and delicate, with patulous spaces. Mitotic figures were easily identified, but atypical forms were not present. The cells were strongly and diffusely immunoreactive with CD34 and bcl-2, while non-reactive with cytokeratin, EMA, actin, ALK-1, S100, desmin, and CD117. These findings confirmed a diagnosis of extraplural solitary fibrous tumor. Without further disease, the patient is alive without evidence of disease, 12 months after surgery. Conclusions The characteristic histologic pattern of solitary fibrous tumor can be noted in extrapulmonary locations. Development in the larynx is uncommon, but the tumor presents as a polypoid mass with characteristic histologic and immunophenotypic features. Conservative local excision is the treatment of choice to yield an excellent prognosis.
Solitary fibrous tumor of the larynx: report of two new cases
Jornal Brasileiro de Patologia e Medicina Laboratorial, 2014
Solitary fibrous tumor is a rare neoplasm. Few cases have been described in the head and neck area, and less than 11 were located in the larynx. We described two new cases of solitary fibrous tumor of the larynx. A man, 64-year-old, and a woman, 77-year-old, both with submucosal and nodular supraglottic lesions, were submitted to surgical treatment and both showed CD-34 and bcl-2 immunoreactivity and S-100 and smooth-muscle actin negativity. After 24 and 22 months of postoperative follow-up, respectively, they did not show signs of active disease.
Extensive solitary fibrous tumor of the retropharyngeal space
Head & Neck, 2006
Background. Solitary fibrous tumor (SFT) is a rare neoplasm whose histologic diagnosis poses significant problems in differential diagnosis. Although most of these neoplasms arise at the level of the pleura, there have also been reports of extrapleural origins. The most frequent localization in the head and neck region is in the nasal cavity.
Solitary fibrous tumor of the parapharyngeal space
Ear, nose, & throat journal, 2007
Solitary fibrous tumors are benign neoplasms of mesenchymal origin. They usually arise from the visceral or parietal pleura and peritoneum, although they have been found in many areas throughout the body. We report a case of solitary fibrous tumor of the parapharyngeal space. Microscopically, the tumor contained spindle cells with areas of marked hypercellularity without a definitepattern. Consistent with a benign lesion, there were few mitoses and no necrosis. The tumor cells stained strongly positive for CD34 and vimentin. At the 2-year follow-up, the patient was well and free of local and/or distant disease.
Egyptian Journal of Ear, Nose, Throat and Allied Sciences, 2019
Solitary Fibrous Tumors (SFTs) are relatively rare benign neoplasms that commonly occur in the pleura and barely reported in parapharyngeal space. SFT is often misdiagnosed due to its microscopic resemblance to several other spindle cell tumors; however, there are specific diagnostic features on MRI and immunohistochemical.We herein report a case of a 65-year-old male patient with SFT arisen in the parapharyngeal space completely resected through a transoral approach. Also, a comprehensive review of previously published cases and case series of parapharyngeal space SFTs and hemangiopericytoma (HPC) reported globally in English up to August 2018 using the PubMed/Medline databases was presented. In addition to the current case, there are thirteen SFTs and thirteen HPCs reported cases. All cases were presented and analyzed. Males are predominantly affected. Actually, 23% of HPCs reported cases presented with the histological indicator of aggressive behavior while none of SFTs reported ...
Pathology Research and Practice, 2001
We describe a case of aggressive fibromatosis of the larynx occurring in a 75-year-old man. The lesion manifested with voice hoarseness and swallowing difficulty. A computerized tomographic scan of the neck revealed distortion of the glottic profile. A malignant tumor was suspected. Although a laryngoscopy-driven biopsy was non-diagnostic, total laryngectomy was done, since the lesion was not deemed amenable to conservative therapy. Grossly, the glottic rim was infiltrated by a hard, grey-white tissue showing a tentacular outline. Tissue sections featured a moderately cellular lesion composed of spindle cells with bland, tapered nuclei, enmeshed in a variably collagenized ground substance. Delicate spindle cell fascicles surrounded the native submucosal seromucous glands and had invaded the thyroid cartilage and the thyroid gland as well. The spindle cells were immunopositive for actins and vimentin, and negative for keratins, epithelial membrane antigen, desmin, and S-100 protein. No further therapy was administered. Periodic follow-up visits were negative. The patient died 5 years after surgery of myocardial infarction with no clinical evidence of lesion recurrence. Based on the available literature, our data confirm that laryngeal fibromatosis in adult patients is a locally infiltrating and progressive disease. Total laryngectomy with clear margins is needed as to avoid the high risk of local recurrence.
Solitary neurofibroma of the larynx: a diagnostic challenge
BMJ Case Reports, 2021
Solitary neurofibromas of the larynx are extremely rare, with a total of 15 cases described in the literature. Nonetheless, acquaintance with this diagnosis is important, as misdiagnoses can have negative consequences. Presenting symptoms are non-specific and depend on tumour size and location. As well-defined submucosal masses with a broad differential diagnosis, they remain a clinical and radiological challenge. While some characteristics might favour a benign nature and subtle signs might help narrow the differential diagnosis, imaging alone is not sufficient for differentiation and definitive diagnosis requires a biopsy. Complete surgical resection and long-term follow-up is indicated. We share our experience on a case of a solitary laryngeal neurofibroma in a middle-aged woman, presenting with a large well-defined paraglottic lesion.