Takayasu Arteritis: Early Diagnosis Leading to Better Outcome and Quality of Life (original) (raw)
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Retrospective evaluation of 22 patients with Takayasu’s arteritis
Rheumatology International
Takayasu’s arteritis (TA) is a rare, idiopathic, inflammatory, granulomatous vasculitis that affects the aorta and its primary branches. Clinical features and the pattern of arterial involvement show differences in different regions of the world according to ethnic influences. Our aim in this retrospective study was to evaluate the demographic, clinic, laboratory, and angiographic findings of 22 patients with TA followed by our clinic and also compare our results with series from the literature. The hospital files of the 22 patients followed by our clinic between 1998 and 2009 were retrospectively evaluated. We also compared our results with the series from the literature that we were able to reach by US National Library of Medicine, National Institute of Health. Gender distribution, age at diagnosis, and type of aortic involvement were similar with the study from Turkey. Different clinical manifestations of Takayasu’s arteritis have been described in different ethnic groups. We also want to underline the coincidence of TA and other rheumatic diseases such as sarcoidosis, SLE, RA, and psoriatic arthritis, different from other published series.
Takayasu Arteritis: An Exceptionally Advanced Clinical Presentation
CERN European Organization for Nuclear Research - Zenodo, 2022
Takayasu Arteritis (TKA) is granulomatous inflammation of the proximal aorta and its main branches, characterized by granulomatous inflammation. As compared to Giant Cell Arteritis (GCA), diagnosis of TKA is a clinical challenge owing to vague initial symptoms and impossibility to biopsy major vessels, therefore, clinical and radiological parameters are the main diagnostic standards. Ishikawa's guidelines were the first clinical guideline regarding the diagnosis of TKA, however, guidelines by the American College of Rheumatology are the mainstay of clinical diagnosis. The development of TKA has been associated with Mycobacterium tuberculosis infection and with rheumatic fever in case series, but the exact trigger factor is unknown to the best of our knowledge. Damage caused by TKA is irreversible due to ischemic changes, therefore active disease status, and end-organ damage presenting as renal artery stenosis, severe hypertension, and shrunken kidneys are the poor prognostic factors. TKA is the most common cause of non-atherosclerotic vascular stenosis. We present a case of a young female, who presented at 16 years of age with involvement of ascending and descending aorta that required coronary artery bypass grafting at age of 17 and later on required Percutaneous Coronary Stenting to Left Main Stem too. Due to worsening hypertension and shrinking kidneys, she required renal artery stenting. In the course of progression, she developed radial artery and carotid artery stenosis, however, the disease progress started to halt, once she was started on glucocorticoids.
A Case Report: A 37 Years-old Women with Takayasu Arteritis
Journal of Pharmaceutical Research International, 2021
Background: A rarity of form of vasculitis, also known as TAK, induces inflammation in the walls of the major arteries in the body: the aorta and its main branches. The disease results from a body attack and inflammation of the walls of the arteries caused by the body's own immune system. Case Presentation: A 37-years-old women had complaints of fever, giddiness, weakness of right upper limb and lower limb since1 day. After undergoing whole blood count, liver function examination, renal and MRI function checks, CT scan, angiography, etc. was studied. She was diagnosed with takayasu arteritis. She had past medical history of neck pain and numbness since January 2020. For these complaints her family members referred her in private hospital. There is no significant history of surgery in present, lower segment caesarean section and piles operation was done previously. Physical findings were normal except the Glasgow Coma Scale score was 11 that is, patient was semi-conscious, In G...
Case Report of Takayasu’s Arteritis
Journal of Evidence Based Medicine and Healthcare, 2016
Takayasu's arteritis (Idiopathic Medial Arthropathy) or "Pulseless" disease is a rare, idiopathic, chronic granulomatous vasculitis that affects aorta and its major branches. This report describes a 30-year-old female who presented with generalised weakness, fatigue, headache, and bilateral arm claudication. Her bilateral upper limb colour duplex study revealed bilateral common carotid arteries and subclavian arteries luminal narrowing and CT angiography revealed vessel wall thickening of aorta and its branches with occlusion. She was diagnosed as having Takayasu's disease (Type V).
Uncommon associations and catastrophic manifestation in Takayasu arteritis: an autopsy case report
Cardiovascular Pathology, 2014
Takayasu arteritis, a chronic inflammatory vasculitis affecting aorta and its major branches is complicated by stenosis, occlusion and aneurysm formation. The aneurysm formation and subsequent complications such as heart failure, aortic regurgitation and aneurysm rupture can be fatal. The aortic aneurysm rupture is a rare and fatal complication with only a few cases reported in the English literature. The involvement of coronary artery in Takayasu occurs in about 10% patients and the coronary artery aneurysm is the least common manifestation. Here we describe a case of Takayasu arteritis with abdominal aortic aneurysm rupture and coronary artery aneurysm. This patient also had associated systemic inflammatory diseases like sarcoidosis and Hashimoto's thyroiditis.
Jundishapur Journal of Chronic Disease Care
Background: Takayasu is a form of large vessel vasculitis that mainly affects the aorta and its branches. It is a chronic disease, and the long-term prognosis depends on arterial complications and its progressive stage. Objectives: This project is a single-center descriptive study of Takayasu’s arteritis patients in Arak city aimed to determine these demographic patterns, which can help physicians in early diagnosis. Methods: All Takayasu’s arteritis patients referred to the rheumatology center of Amir Al-Momenin subspecialty clinic were studied from 2009 to 2019. Imaging methods were used for diagnosis, and SPSS version 23 was used for statistical analysis. Results: Out of 17 registered patients, information of nine patients was available from the beginning of diagnosis. Constitutional signs and symptoms indicated an inflammatory process in 77.78% of the patients. All patients in this study received a steroid-sparing drug as a part of the treatment, and the most commonly used drug ...
Takayasu arteritis: a cohort of Italian patients and recent pathogenetic and therapeutic advances
Clinical and Experimental Medicine
Takayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of southern Italy. The cohort included 43 patients who were diagnosed with TAK and followed up according to a standard protocol, in a collaboration between four university tertiary referral centers and a regional hospital. Clinical and imaging classification criteria were those established by the American College of Rheumatology. Thirty-five patients (81.4%) were female, and the mean age at disease onset was 32.6 (range 16–54) years. Angiographic assessment of the vascular involvement allowed disease classification in five different types. Clinical features ranged from constitutional symptoms in the early inflammatory stage of the disease to cardiovascular ischemic symptoms in th...
Cureus, 2021
Takayasu's arteritis is a rare form of chronic inflammatory disorder involving large vessels, with an unclear etiology. Common early signs and symptoms are weakness, malaise, and fever. Takayasu's arteritis mainly involves the aorta and its branches as well as the subclavian and carotid arteries. While radiologic methods can identify diseased vessels, they can't tell the difference between active and chronic lesions. This study reviews the characteristics of Takayasu's arteritis to identify any possible changes in the prevalence of symptoms of the disease. We conducted a literature review of case reports on Takayasu arteritis from PubMed and Google Scholar. Variables of interest were age, gender, symptoms, blood pressure (BP) measurement, diminished pulses, and radiological findings. Data were transferred to an Excel spreadsheet (Microsoft Corporation, Redmond, WA), and mean, median, and standard deviation, frequencies, and proportions were calculated using R version 1.1.456 (RStudio: Integrated Development for R. RStudio, PBC, Boston, MA). There were 43 cases, and females accounted for 88.3% of the presentations. The average age was 25 years, SD 12.5 years. Fever was the most frequent symptom (20.93%), followed by chest pain (13.95%), claudication (13.95%), and headache (13.95%). Less frequent complaints included shortness of breath (11.62%), weight loss (9.30%), syncope (6.98%), and night sweats (4.65%). On the right side, the average BP was 142/87 mmHg, and the left-sided finding averaged 115/72 mmHg. Decreased pulses were primarily seen in the radial artery with 15 cases. Radiological findings showed narrowing of the vessels in the following order: aorta (22), carotid (11), renal (10), subclavian (9), celiac (2), mesenteric (2), axillary (2), and tibial (1). The characteristics of Takayasu's arteritis were analyzed in this study. It identified several findings, ranging from fever symptoms to the signs of claudication, as well as the involvement of major vessels, such as the aorta and its branches, and a summary of radiological findings. This depicts the picture of Takayasu's arteritis and what physicians should expect when dealing with the disease.
Objective: To analyse the clinical presentation, angiographic findings and outcome following intervention (endovascular and open surgical) in patients with Takayasu?s arteritis. Methods: This is a retrospective observational study of 28 patients who were diagnosed with Takayasu?s Arteritis and who presented to the department of Vascular Surgery, between January 2012 to January 2018. Their clinical presentation , angiographic findings, and outcome following intervention was analyzed. Results: 28 patients were analysed during study period. Among 28 patients, 25(89%) were female and 3(11%) were male. Average age of presentation was 29.34 years. Constitutional symptoms were reported in 13 patients(46.43%) and claudication in 11 patients(32%) .The commonest finding was hypertension in (57%) followed by absent pulses in 10 patients (42%). Major organ involvement was seen as cerebrovascular accident in 1 patient(7.14%) and cardiac findings included - chest pain 2(10.71%), aortic regurgitation 4(14.29%), mitral regurgitation or valve prolapse 2(7%) and pulmonary hypertension 2(7%) . According to the new angiographic classification,type I(32.14%) was encountered most frequently, followed by type III (25%), type IV (21.4%), type V (14%) and type IIb(7%) .The commonly involved vasculature was abdominal aorta(32%) , renal artery(25%) ,left subclavian (25%) followed by thoracic aorta(14%) and right subclavian (10%). Renal artery angioplasty was done in 5 patients and aneurysm repair was done in 1 patient with good outcome. Conclusion:-Takayasu?s Arteritis is a rare disease, with female predominance and varied clinical presentation. Angiography findings and clinical symptoms are integrated to decide management. Angiographic evaluation and percutaneous transluminal angioplasty with stenting is useful in selected cases; while majority of the patients are managed medically.
Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients
Clinical and experimental rheumatology
Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%...