Retrospective evaluation of 22 patients with Takayasu’s arteritis (original) (raw)
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Takayasu arteritis: a cohort of Italian patients and recent pathogenetic and therapeutic advances
Clinical and Experimental Medicine
Takayasu arteritis (TAK) is a rare granulomatous vasculitis of unknown etiology that mainly affects the aorta and its major branches. The aim is to describe the clinical features, diagnostic procedures, pathogenesis, and management of TAK in a longitudinal cohort of patients recruited within a single region of southern Italy. The cohort included 43 patients who were diagnosed with TAK and followed up according to a standard protocol, in a collaboration between four university tertiary referral centers and a regional hospital. Clinical and imaging classification criteria were those established by the American College of Rheumatology. Thirty-five patients (81.4%) were female, and the mean age at disease onset was 32.6 (range 16–54) years. Angiographic assessment of the vascular involvement allowed disease classification in five different types. Clinical features ranged from constitutional symptoms in the early inflammatory stage of the disease to cardiovascular ischemic symptoms in th...
Jundishapur Journal of Chronic Disease Care
Background: Takayasu is a form of large vessel vasculitis that mainly affects the aorta and its branches. It is a chronic disease, and the long-term prognosis depends on arterial complications and its progressive stage. Objectives: This project is a single-center descriptive study of Takayasu’s arteritis patients in Arak city aimed to determine these demographic patterns, which can help physicians in early diagnosis. Methods: All Takayasu’s arteritis patients referred to the rheumatology center of Amir Al-Momenin subspecialty clinic were studied from 2009 to 2019. Imaging methods were used for diagnosis, and SPSS version 23 was used for statistical analysis. Results: Out of 17 registered patients, information of nine patients was available from the beginning of diagnosis. Constitutional signs and symptoms indicated an inflammatory process in 77.78% of the patients. All patients in this study received a steroid-sparing drug as a part of the treatment, and the most commonly used drug ...
Takayasu's arteritis in Turkey - clinical and angiographic features of 248 patients
Clinical and experimental rheumatology
Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis affecting the aorta and its major branches. Although it is more prevalent in Far-East Asia, the distribution of the disease is worldwide with different vascular involvement patterns and clinical manifestations. The objective of this study was to evaluate the demographic, clinical, angiographic and prognostic features of TA patients in Turkey. Clinical and angiographic findings of 248 TA patients (228 female, 27 male) followed at 15 Rheumatology Centers were prospectively evaluated according to a predefined protocol. The mean age was 40.1 years (30.2 years at the clinical onset). Clinical manifestations included constitutional symptoms in 66%, absent or diminished pulses in 88%, bruits in 77%, extremity pain in 69%, claudication in 48%, hypertension in 43% and cerebrovascular accidents (CVA) in 18% of the patients. Renal artery stenosis, aortic regurgitation and pulmonary hypertension were present in 26%, 33% and 12%...
Takayasu Arteritis: Early Diagnosis Leading to Better Outcome and Quality of Life
British Journal of Medical and Health Research, 2020
Takayasu arteritis is an inflammatory and stenotic disease of medium and large-sized arteries characterized by a strong predilection for the aortic arch and its branches. It has complex clinical presentation and 3 stage scheme is used for simplification with most patients presenting late delaying the diagnosis. We are reporting a case of 40 years old female patient presenting in second stage (vasculitic) of this rare disease. This report highlights the fact that diagnosing this rare type of vasculitis in early stages is critical to management and prevention of dreadful complications like large arteries aneurysm, Pulmonary Hypertension, Renal artery stenosis etc. and leading to better quality of life with less episodes of active disease.
Reumatismo, 2022
Takayasu arteritis (TA) is an extremely uncommon vasculitis that primarily affects the aorta and its branches. Due to the genetic and ethnicity effect, a diverse array of TA clinical manifestations has been reported worldwide. The purpose of the present study was to compare the clinicodemographic characteristics and pattern of vascular involvement of Iranian and Turkish TA patients. This study was a retrospective, cross-sectional investigation of 126 TA patients in Iran and Turkey. All of the variables analyzed were extracted from historical medical records. In 126 TA patients, the ratio of females to males was 8.6:1, and the average age at onset of disease was 30.5±11.1 years. Fatigue (49.2%) and a weak or absent pulse (79.4%) were the most prevalent symptoms and signs, respectively. The most prevalent angiographic classifications were types V and I in Iranian patients (41.09%) and type I in the Turkish population (47.7%) The left subclavian artery was the vessel most frequently affected by TA (66.6%). Our findings indicated that there were no significant differences between the two countries in terms of clinicodemographic characteristics or vascular involvement. Some clinical manifestations, such as claudication, were more prevalent in the Turkish population due to a higher incidence of occlusive lesions in the right subclavian artery.
Takayasu Arteritis: An Exceptionally Advanced Clinical Presentation
CERN European Organization for Nuclear Research - Zenodo, 2022
Takayasu Arteritis (TKA) is granulomatous inflammation of the proximal aorta and its main branches, characterized by granulomatous inflammation. As compared to Giant Cell Arteritis (GCA), diagnosis of TKA is a clinical challenge owing to vague initial symptoms and impossibility to biopsy major vessels, therefore, clinical and radiological parameters are the main diagnostic standards. Ishikawa's guidelines were the first clinical guideline regarding the diagnosis of TKA, however, guidelines by the American College of Rheumatology are the mainstay of clinical diagnosis. The development of TKA has been associated with Mycobacterium tuberculosis infection and with rheumatic fever in case series, but the exact trigger factor is unknown to the best of our knowledge. Damage caused by TKA is irreversible due to ischemic changes, therefore active disease status, and end-organ damage presenting as renal artery stenosis, severe hypertension, and shrunken kidneys are the poor prognostic factors. TKA is the most common cause of non-atherosclerotic vascular stenosis. We present a case of a young female, who presented at 16 years of age with involvement of ascending and descending aorta that required coronary artery bypass grafting at age of 17 and later on required Percutaneous Coronary Stenting to Left Main Stem too. Due to worsening hypertension and shrinking kidneys, she required renal artery stenting. In the course of progression, she developed radial artery and carotid artery stenosis, however, the disease progress started to halt, once she was started on glucocorticoids.
Cureus, 2021
Takayasu's arteritis is a rare form of chronic inflammatory disorder involving large vessels, with an unclear etiology. Common early signs and symptoms are weakness, malaise, and fever. Takayasu's arteritis mainly involves the aorta and its branches as well as the subclavian and carotid arteries. While radiologic methods can identify diseased vessels, they can't tell the difference between active and chronic lesions. This study reviews the characteristics of Takayasu's arteritis to identify any possible changes in the prevalence of symptoms of the disease. We conducted a literature review of case reports on Takayasu arteritis from PubMed and Google Scholar. Variables of interest were age, gender, symptoms, blood pressure (BP) measurement, diminished pulses, and radiological findings. Data were transferred to an Excel spreadsheet (Microsoft Corporation, Redmond, WA), and mean, median, and standard deviation, frequencies, and proportions were calculated using R version 1.1.456 (RStudio: Integrated Development for R. RStudio, PBC, Boston, MA). There were 43 cases, and females accounted for 88.3% of the presentations. The average age was 25 years, SD 12.5 years. Fever was the most frequent symptom (20.93%), followed by chest pain (13.95%), claudication (13.95%), and headache (13.95%). Less frequent complaints included shortness of breath (11.62%), weight loss (9.30%), syncope (6.98%), and night sweats (4.65%). On the right side, the average BP was 142/87 mmHg, and the left-sided finding averaged 115/72 mmHg. Decreased pulses were primarily seen in the radial artery with 15 cases. Radiological findings showed narrowing of the vessels in the following order: aorta (22), carotid (11), renal (10), subclavian (9), celiac (2), mesenteric (2), axillary (2), and tibial (1). The characteristics of Takayasu's arteritis were analyzed in this study. It identified several findings, ranging from fever symptoms to the signs of claudication, as well as the involvement of major vessels, such as the aorta and its branches, and a summary of radiological findings. This depicts the picture of Takayasu's arteritis and what physicians should expect when dealing with the disease.
Case Report of Takayasu’s Arteritis
Journal of Evidence Based Medicine and Healthcare, 2016
Takayasu's arteritis (Idiopathic Medial Arthropathy) or "Pulseless" disease is a rare, idiopathic, chronic granulomatous vasculitis that affects aorta and its major branches. This report describes a 30-year-old female who presented with generalised weakness, fatigue, headache, and bilateral arm claudication. Her bilateral upper limb colour duplex study revealed bilateral common carotid arteries and subclavian arteries luminal narrowing and CT angiography revealed vessel wall thickening of aorta and its branches with occlusion. She was diagnosed as having Takayasu's disease (Type V).
Takayasu Arteritis: Pattern of Clinical and Radiological Features, Experience from Pakistan
Journal of Ayub Medical College Abbottabad
Background: Takayasu arteritis (TKA) is a rare large vessel vasculitis occurring in young adults of less than 50 year of age. We analyse the clinical, radiological features, and treatment regimens in Pakistani patients presenting to a tertiary care center. Methods: A retrospective cross-sectional analysis of TKA patients done at the Rheumatology department of Fatima Memorial Hospital. A comprehensive evaluation of clinical, laboratory, radiographic features and treatment regimens was carried out. Results: A consecutive cohort of 18 patients, with 13 patients (72%) of female gender was studied. Mean age of the cohort was 35.94±2.7 years. A mean delay of 2.32±0.43 years between symptoms and final diagnosis was reported, attributed to alternate diagnosis in 57.1% and late presentation in 42.8% cases. Limb claudication (44.4%), absent pulses (38.9%), were the common initial manifestation. Hypertension (61.5%), blood pressure discrepancy between arms (88.9%) and bruit (72.2%) over major...
Uncommon associations and catastrophic manifestation in Takayasu arteritis: an autopsy case report
Cardiovascular Pathology, 2014
Takayasu arteritis, a chronic inflammatory vasculitis affecting aorta and its major branches is complicated by stenosis, occlusion and aneurysm formation. The aneurysm formation and subsequent complications such as heart failure, aortic regurgitation and aneurysm rupture can be fatal. The aortic aneurysm rupture is a rare and fatal complication with only a few cases reported in the English literature. The involvement of coronary artery in Takayasu occurs in about 10% patients and the coronary artery aneurysm is the least common manifestation. Here we describe a case of Takayasu arteritis with abdominal aortic aneurysm rupture and coronary artery aneurysm. This patient also had associated systemic inflammatory diseases like sarcoidosis and Hashimoto's thyroiditis.